ved in the development of the 3rd cranial nerve and the 6th cranial nerve's nucleus. We propose that oculomotor anomalies, including DRS, could be related to proximal 1p36 deletion, warranting a detailed ophthalmologic evaluation of these patients.
  For a long time, Lebanon has been considered an unstable country. This can have a negative impact on Lebanese adolescents that consequently face secondary emotional stress, leading to more mental health problems such as anxiety, depression, and alexithymia. The objective of this study was to assess the association between alexithymia, depression and aggressive behavior in a sample of Lebanese adolescents.
 
  This is a cross-sectional study, conducted between September 2018 and February 2019, which enrolled 568 young adolescents aged between 15 and 18years using a proportionate sample from two Lebanese governorates. Out of 750 questionnaires distributed, 568 (75.73%) were completed and collected back.
 
  The mean age was 15.87 ± 0.82years, with 302 (53.2%) females; 180 (31.7%) were alexithymic, 193 (34.0%) and 181 (31.9%) had moderate (scores between (89 and 111) and high (scores ≥ 112) aggression respectively, whereas 176 (31.0%) and 149 (26.2%) had moderate (scores between 3 and 4) and high (scores ≥ 5) deprmia remain not fully elucidated.
  Major depressive disorder (MDD) is a recurrent illness with high rates of chronicity, treatment-resistance, and significant economic impact. 
  -Adenosylmethionine (SAMe), a molecule that is formed naturally in the human body, has shown antidepressant effects and may expand the available options for treating MDD. This systematic review examines the evidence concerning the efficacy of SAMe as monotherapy or in combination with antidepressants.
 
  A systematic search in Medline, Psychinfo, AMED, and Cochrane Controlled Trials Register was conducted for any reference recorded up to March 2020. Double-blind, randomised controlled trials, comparing the antidepressant efficacy of SAMe to placebo or/and to other antidepressants, were selected. Two authors evaluated each study independently and then, reconciled findings.
 
  Eight trials, with a total of 11 arms and 1011 subjects, evaluating the efficacy of SAMe used as monotherapy or as adjunctive therapy (512 individuals), were included in this review. The study duraouble-blind randomised controlled studies are warranted to confirm the antidepressant effectiveness of SAMe.
 The existing trials of SAMe, used as monotherapy or add on to another antidepressants, have shown encouraging and generally positive results. However, more evidence is necessary before definitive conclusions can be drawn. Larger, double-blind randomised controlled studies are warranted to confirm the antidepressant effectiveness of SAMe.Lifespan is one of the main components of life history. Shorter lifespans can be expected in marginal habitats. However, in the case of ectotherms, lifespan typically increases with altitude, even though temperature-one of the main factors to determine ectotherms' life history-declines with elevation. This pattern can be explained by the fact that a shorter activity time favors survival. In this study, we analyzed how lifespan and other life-history traits of the lizard Psammodromus algirus vary along a 2,200 m elevational gradient in Sierra Nevada (SE Spain). Populations at intermediate altitudes (1,200-1,700 m), corresponding to the optimal habitat for this species, had the shortest lifespans, whereas populations inhabiting marginal habitats (at both low and at high altitudes) lived longest. Therefore, this lizard did not follow the typical pattern of ectotherms, as it also lived longer at the lower limit of its distribution, nor did it show a longer lifespan in areas with optimal habitats. These results might be explained by a complex combination of different gradients along the mountain, namely that activity time decreases with altitude whereas food availability increases. This could explain why lifespan was maximum at both high (limited activity time) and low (limited food availability) altitudes, resulting in similar lifespans in areas with contrasting environmental conditions. Our findings also indicated that reproductive investment and body condition increase with elevation, suggesting that alpine populations are locally adapted.We share the case of a 86-year-old male patient, followed up for recent left hip pain. Interrogation revealed a fever, nocturnal shivering, and bone pains. Standard radiographs and computed tomography centered on both shoulders and pelvis showed osteoarthritis of the left hip and multiple lytic lesions in both humeral heads and clavicles, suggestive of chronic infectious, metabolic, or secondary disease. Bone scan with radiobiphosphonates showed intense and diffuse uptake in the clavicles, the two humeral heads, and at the cervical and dorsal spine. Biopsy of the left humeral head confirmed the diagnosis of tuberculous osteomyelitis, showing an aspect of caseo-follicular tuberculosis. Bone scan with radiobiphosphonates can be used in our context to search other localizations falling within the framework of a polystotic form, and also to guide nonrisk biopsy in such group of patients.The most commonly accepted pathophysiologic mechanism for the appearance of the "hot rim" sign is inflammatory changes from the gallbladder spreading to and affecting the surrounding liver. The "hot rim" sign has clinical relevance, because it is associated with a high incidence of perforated or gangrenous cholecystitis. The presence of these above-mentioned conditions increases the likelihood of complications and warrants urgent surgical evaluation. We present present the findings of on hepatobiliary scintigraphy and adjunct single-photon emission computed tomography/computed tomography-fused imaging in a case of acalculous cholecystitis, which has been confirmed on histopathology (marked degree of acute gangrenous cholecystitis).Positron emission tomography-computed tomography (PET-CT) has evolved as an important diagnostic tool in the diagnosis and management of breast carcinoma.  https://www.selleckchem.com/products/Staurosporine.html  PET/CT can help in staging as well as detecting metastases to mediastinal, axillary, and internal mammary nodes. However, PET-CT is not useful in differentiating between inflammation and malignancy.