In addition, we also explored pGH's biology in hepatocytes from neonatal pig, it can be found that pGH/GHR could translocate into the cell nucleus, which implies that pGH/GHR may exhibit physiological roles based on their nuclear localization. We found that pGH could not trigger intracellular signaling in the hepatocytes of neonatal pigs, but not young pigs, which provides an important explanation for why the growth of neonatal pig is GH independent.Purpose The research examines homesickness in organisationally assigned expatriates from developing countries or Global South serving in Western contexts. It investigates the extent to which homesickness has personal and organisational consequences and explores the coping mechanisms used by expatriates. Design/methodology/approach This is a qualitative research built on unstructured interviews with organisationally assigned expatriates from the Global South. Findings The research found that homesickness has consequences for both expatriates and organisations. These consequences include psycho-social disorder, deterioration of physical health which damagingly affects individual well-being, work outcomes and organisational commitment. Practical implications The practical implications centre on the opportunity for policy and strategy formulation by international human resource management (HRM) within organisations to improve the mental health of Global South expatriates, thus seeding the ingredients for better performance and job satisfaction. Originality This research makes significant additions to the expatriate literature in exposing the homesickness experiences of expatriates from the Global South in advanced economies. Two main coping frameworks used by expatriates are proposed. These copying frameworks centre on positive practices and negative practices which, in turn, encapsulate five adjustment approaches.  https://www.selleckchem.com/products/tas4464.html  The research explains how Global South expatriates use these models in practice.Bipolar magnetic semiconductors (BMSs) are a new member of spintornic materials. In BMSs, one can obtain 100% spin-polarized currents by means of the gate voltage. However, most of previous studies focused on their applications in spintronics instead of spin caloritronics. Herein, we show that BMS is an intrinsic model for spin Seebeck effect (SSE). Without any gate voltage and electric field, currents with opposite spin orientation are generated and flow in opposite directions with almost equal magnitude when simply applying a temperature bias. This is also due to the special electronic structure of BMS where the conduction and valence bands near the Fermi level belong to opposite spin orientation. Based on density function theory and non-equilibrium Green's function methods, we confirm the thermal-induced SSE in BMS using a case of magnetic MoS2 nanotube. The magnitude of spin current in zigzag tube is almost four times higher than that in armchair tube. BMS is promising candidates for spin caloritronic applications.Zinc as a biomarker can be used to diagnose the early stage prostate cancer, while ZIP1 protein, a zinc transporter is significantly down-regulated in prostate cancer cells. This behavior leads to the apparent alteration of the enrichment ability for zinc between early prostate cancer tissues and healthy tissues. This difference inspires us to develop a novel Zn2+ sensor that applies to the clinic diagnosis of early prostate cancer. We designed a tetrapeptide sensor H2L (Dansyl-Gly-Pro-Trp-Gly-NH2) according to the photo-induced electron transfer principle (PET), and it performed adequately in Zn2+ imaging of prostate cell lines. Based on the assessment of Zn2+ enrichment ability, there was distinctly lower Zn2+ concentrate in prostate cancer cell lines than healthy prostate epithelial cells. Furthermore, H2L displayed high sensitivity with a detection limit as low as 49.5 nM, and high specificity for Zn2+ detection. Also the low toxicity and the superior cell permeability of H2L made the imaging of Zn2+ ions detection safe and rapid. We expect that H2L to be a powerful tool for early diagnosis of prostate cancer and a good indicator for the precise resection of cancer tissue during surgery.Inorganic or inorganic-organic hybrid nanomaterials have great potential for applications in the biomedical fields. Biological half-life is an essential pharmacokinetic parameter for these materials to function in vivo. Compared to inductively coupled plasma mass spectrometry (ICP-MS), which is the gold standard, laser-induced breakdown spectroscopy (LIBS) is a faster and more efficient elemental detection method. We investigated an efficient way to quantify the metabolic rate using LIBS. Nanoparticle platforms, such as manganese dioxide-bovine serum albumin (MnO2-BSA) or boehmite-bovine serum albumin (AlO(OH)-BSA) were injected into mice through intravenous administration for LIBS spectrum acquisition. First, the spectral background was corrected using the polynomial fitting method; The spectral interference was eliminated by Lorentz fitting for each LIBS spectrum simultaneously. The support vector regression (SVR) was then used for LIBS quantitative analyses. Finally, the LIBS results were compared with the ICP-MS ones. The half-lives of MnO2-BSA calculated by LIBS and ICP-MS were 2.49 and 2.42 h, respectively. For AlO(OH)-BSA, the half-lives detected by LIBS and ICP-MS were 3.46 and 3.57 h, respectively. The relative error of LIBS is within 5% compared to ICP-MS. The results demonstrate that LIBS is a valuable tool for quantifying the metabolic rates with a high degree of accuracy.Single gene mutations have been implicated in the pathogenesis of a form of diabetes mellitus (DM) known as the maturity-onset diabetes of the young (MODY). However, there are diverse opinions on the suspect genes and pathophysiology, necessitating the need to review and communicate the genes to raise public awareness. We used the Google search engine to retrieve relevant information from reputable sources such as PubMed and Google Scholar. We identified 14 classified MODY genes as well as three new and unclassified genes linked with MODY. These genes are fundamentally embedded in the beta cells, the most common of which are HNF1A, HNF4A, HNF1B, and GCK genes. Mutations in these genes cause β-cell dysfunction, resulting in decreased insulin production and hyperglycemia. MODY genes have distinct mechanisms of action and phenotypic presentations compared with type 1 and type 2 DM and other forms of DM. Healthcare professionals are therefore advised to formulate drugs and treatment based on the causal genes rather than the current generalized treatment for all types of DM.