https://www.selleckchem.com/products/pik-iii.html The use of reference materials (RMs) is critical for validating and testing the accuracy of analytical protocols. The National Institute of Standards and Technology (NIST) is in initial stages of developing a glyphosate in oats RM. The first aim of this study was to optimize and validate a robust method for the extraction and analysis of glyphosate and aminomethylphosphonic acid (AMPA). The optimized method was used to screen thirteen commercially available oat products to identify candidate RMs. Glyphosate was detected in all samples, with the highest glyphosate mass fraction of 1100 ng/g; lower levels were measured in grains from organic agriculture. AMPA was quantified in nine samples up to 40 ng/g. The findings of this study led to the identification of candidate RMs, with "high" and "low" glyphosate levels. A preliminary stability study determined that glyphosate is stable in oat material at room temperature for six months.Plastics have been recognized as a serious threat to the environment. Besides their own toxicity, microplastics can interact with other environmental pollutants, acting as carriers and potentially modulating their toxicity. In this study, the toxicity of polystyrene (PS) microplastic fragments (plain PS; carboxylated PS, PS-COOH and aminated PS, PS-NH2) and triphenyl phosphate (TPhP) (an emerging organophosphate flame retardant) at the environmentally relevant concentrations to the marine medaka (Oryzias melastigma) larvae was investigated. Larvae were exposed to 20 μg/L of microplastic fragments or 20 and 100 μg/L of TPhP or a combination of both for 7 days. The results showed that the three microplastics did not affect the larval locomotor activity. For TPhP, the larval moving duration and distance moved were significantly decreased by the TPhP exposure, with a maximum decrease of 43.5% and 59.4% respectively. Exposure to 100 μg/L TPhP respectively down-regulated the expression levels of sin