Diagnostic in vitro is needed to choose the level of medical establishment for conduction of oral provocation tests in case a specific IgE index is over 0.7 kU/L, testing is performed in an intensive care unit, if IgE is less than 0.7 kU/L - in a specialized inpatient department. Three clinical cases involving different methods have been presented for diagnosing cow's milk protein allergy - elimination and provocation test, oral provocation test and administration of individual diet based on the obtained results. A complex diagnostic approach, in particular, study of anamnesis, record of nutrition diary, elimination diet, enables to optimize diagnostics of food allergy, and diagnostic addition of a product - to assess tolerance clinically during extension of diet. An elaborated method of diagnosing cow's milk protein allergy in children younger than one year of age can be recommended for wide use in a clinical practice.Aim of study - to determine the composition of the essential macro and microelements in the hair and dental hard tissues and to study the influence of their imbalance on the general and dental health of the child. To assess the state of dental hard tissues, 375 children aged 3 to 12 years were randomly examined in Batumi. Monitoring of the examined children was carried out using standard indices provided by the World Health Organization.  https://www.selleckchem.com/autophagy.html  To determine the composition of the chemical elements in hair and dental hard tissues, according to the caries status 48 children were chosen from the examined 375 children. We used X-ray fluorescent spectroscopy method to study the qualitative and quantitative content of the chemical elements in the hair and dental hard tissues. The comparative analysis of the dental experience (dmft/DMFT) and the composition of chemical elements in dental hard tissues showed a statistically significant difference depending on caries status. The effect of some essential elements on the general health of the child has also been identified. The study into the composition of the essential macro and microelements in the hair and dental hard tissues revealed a high coefficient of correlation both with the mineralization of dental hard tissues and with the general health of the growing body.The method of dental implantation in patients with generalized periodontitis is one of the priority areas requiring in-depth study. The aim of the study was to increase the efficiency of dental implantation in prosthetic rehabilitation of patients with generalized periodontitis. A study of 240 patients with chronic generalized periodontitis and partial edentulous upper and lower jaw was carried out, who subsequently underwent complex periodontal treatment and dental implantation. The patients were divided into groups depending on the severity of generalized periodontitis (I, II, III) and the method of treatment. Evaluation of the results of the effectiveness of the proposed method of surgical treatment of patients with generalized periodontitis of the first stage of development with one-stage and staged dental implantation and targeted osteotropic therapy showed that after 12 months all implants (100%) were preserved. In patients with grade II generalized periodontitis, who underwent periodontal treatment and dental implantation in stages, the safety of implants was 92.1%, and in patients who underwent one-stage dental implantation with surgical treatment of periodontal disease, the safety of implants was 89,4%. In patients with stage III generalized periodontitis who underwent staged periodontal treatment and dental implantation, the safety of implants was 80,2%, and in patients who underwent one-stage dental implantation and periodontal treatment - 51,7%.Diseases of the oral cavity are considered as a health problem for the population of the whole world, in particular, Ukraine. Purpose of the study - to analyze the risk factors, legislative, financial, personnel support for the prevention and treatment of oral diseases of the population of Ukraine; to develop a national conceptual model for the organization of dental care. State statistics data, regulatory documents, scientific sources; methods of systems approach and analysis, conceptual modeling, graphic. A low standard of living is typical for 23.1% of the population of Ukraine; high levels of tobacco smoking, alcohol consumption, sugar consumption, insufficient amount of fruits and vegetables in the diet are common in the population. Low fluoride content in drinking water is a threat to the development of caries. The legal regulation of oral health needs improvement. A national conceptual model of the organization of dental care has been developed on the basis of an analysis of world experience and WHO recommendations, the main components of the model are determined improving geographical and financial accessibility; improving quality; preventive focus; state regulation. The world experience in the provision of dental care and the national characteristics of the health care system made it possible to substantiate and develop a conceptual model for organizing dental care for the population of Ukraine.The aim of our study was to investigate the effectiveness of osteoplastic material based on MMSC - AT for the restoration of bone defects. To study the processes of bone remodeling, in the replacement of bone defects after tooth extraction, patients were divided into three groups. Group A - 26 patients where used "Kolapan-L" to fill the bone defect; group B - 28 patients where for augmentation used osteoplastic composition "Kolopan-L" + MMSC-AT + PRP; group C - 25 patients in whom the healing of the bone defect occurred under a blood clot. In the patients group B, after 1 year of observation, the activity of acid phosphatase was 13,35% p> 0.05 and 33,40%, p>0,05, p10,05, p2 less then 0,05. When conducting histological examination of bone biopsies after 6 months of observation, in patients of group B, the obtained trepan biopsies had the structure of bone tissue bone marrow spaces and sometimes small particles of osteoplastic material were determined between trabeculae. Therefore, based on the results of the study, it is safe to say that our proposed osteoplastic composition based on MMSC - AT is a good alternative to traditional osteoplastic materials for use in modern dentistry.