https://www.selleckchem.com/products/combretastatin-a4.html The overall estimated pooled prevalence of the pathogens among the human population was 4.27% (95%CI 4.03-4.51%; p less then 0.001) with significant heterogeneity (I2 = 99.50%). The top three highest prevalent pathogens were M. tuberculosis (30.90%; 22.75-39.04%; p less then 0.001; I2 = 99.70%) followed by Toxoplasma gondii (21.93%; 6.23-37.61%; p less then 0.001; I2 = 99.30%) and hepatitis E virus (18.29%; 11.72-24.86%; p less then 0.001; I2 = 96.70%). However, there is a knowledge gap about the listed pathogens regarding the occurrence, transmission pathways, and rodent role in transmission dynamics at the human-animal-environment interface in Qatar. Further studies are required to explore the role of rodents in spreading zoonotic pathogens through the One Health framework, consisting of zoologists, ecologists, microbiologists, entomologists, veterinarians, and public health experts in this country.L-carnitine (LC) supplementation improves cardiac function in hemodialysis (HD) patients. However, whether reducing LC supplementation affects carnitine kinetics and cardiac function in HD patients treated with LC remains unclear. Fifty-nine HD patients previously treated with intravenous LC 1000 mg per HD session (three times weekly) were allocated to three groups LC injection three times weekly, once weekly, and placebo, and prospectively followed up for six months. Carnitine fractions were assessed by enzyme cycling methods. Plasma and red blood cell (RBC) acylcarnitines were profiled using tandem mass spectrometry. Cardiac function was evaluated using echocardiography and plasma B-type natriuretic peptide (BNP) levels. Reducing LC administration to once weekly significantly decreased plasma carnitine fractions and RBC-free carnitine levels during the study period, which were further decreased in the placebo group (p less then 0.001). Plasma BNP levels were significantly elevated in the placebo group (p = 0.