Technical and clinical (Eckardt score ≤ 3) success were 100% and 91%, respectively (follow-up 3-21 months). In 2 cases, the experienced endoscopist intervention was required (cases 2 and 3) because of difficult orientation at the esophagogastric junction. One mild pneumoperitoneum occurred, with no severe adverse events reported.
 
  Training in animal models and supervision by experienced endoscopist during first cases could provide the necessary skills to perform POEM safely and effectively.
 Training in animal models and supervision by experienced endoscopist during first cases could provide the necessary skills to perform POEM safely and effectively.We present the case of a patient diagnosed with HIV who developed cirrhosis due to chronic hepatitis E. The good response of this chronic infection is evident in our immunosuppressed patient with a 12-week treatment with Ribavirin.
  Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a safe and effective technique in the diagnosis of mediastinal and abdominal masses. However, the usefulness of EUS-FNA in the diagnosis and classification of lymphomas is controversial. Our aim was to determine the yield of EUS-FNA in the diagnosis and classification of lymphomas.
 
  A retrospective case series was performed in a tertiary referral center. All consecutive patients referred for EUS-FNA who had a suspected diagnosis of lymphoma from March 2013 to June 2019 were included.
 
  35 patients (54.3% women, median age 72 years) were included. The most frequent localization of the node was the abdomen (67.9%). Nodes were punctured using 22-gauge (85.7%) and 19-gauge needle (14.3%) with slow-pull technique. The number of passes performed were three or more in 82.9% of patients. The samples were processed by cell block method. Adequate samples for immunohistochemical and molecular biological study were obtained in 33 (94.3%) patients. EUS-FNA correctly diagnosed lymphoma in 30 out of 35 patients (85.7%), and subclassification was determined in 23 patients (65.7%). The most frequent diagnosis was Non-Hodgkin Lymphoma (85.7%). There was one moderate adverse event (bleeding), which was solved during the procedure.
 
  EUS-FNA may be a valuable technique in the evaluation ofsuspected lymphomas with an adequate diagnostic yield and a very low adverse events rate.
 EUS-FNA may be a valuable technique in the evaluation of suspected lymphomas with an adequate diagnostic yield and a very low adverse events rate.
  Endoscopic submucosal dissection has been widely recognized by patients and doctors for its advantages for early gastric cancer. The accurate prediction of the risk of lymph node metastasis in early gastric cancer is important to select patients suitable treatments for this procedure. Unfortunately, the accuracy of endoscopic ultrasound and computed tomography in the diagnosis of early gastric cancer lymph node status is extremely limited.
 
  This study was aimed to identify the risk factors of lymph node metastasis in early gastric cancer. Based on which, a nomogram risk prediction model was then constructed to accurately determine the possibility of lymph node metastasis in early gastric cancer for guiding further treatment of clinicians.
 
  A retrospective examination of records of early gastric cancer patients undergoing radical gastrectomy from August 2012 to August 2019 in the Gastrointestinal Center of Subei people's Hospital was conducted. The clinicopathological data were classified into the trainingk prediction model of lymph node metastasis has been established for early gastric cancer patients to assist in formulating personalized treatment plans.Testicular mixed germ cell tumor is characterized by high degree of malignancy and prone to metastasis, the common of which is retroperitoneal lymph node metastasis. At present, EUS has a very important diagnostic value for mediastinal, enterocoelia and retroperitoneal lymph node metastasis of malignant tumors. It also has a positive value for the space occupying of parenchyma or cavity organ and can be used for the puncture operation of multiple lesions under real-time ultrasound monitoring with high safety and small complications.
  submucosal tunneling endoscopic resection (STER) can be an effective treatment for submucosal tumors (SMTs) in the esophagus and cardia. However, STER may be more difficult to perform in the stomach than in the esophagus due to special anatomical and physiological features. The feasibility of STER to remove gastric STMs has not been systematically investigated. Therefore, this meta-analysis aimed to evaluate the safety and efficacy of STER for gastric SMTs.
 
  a comprehensive literature search of the Medline, Embase, PubMed, and Cochrane Library databases was conducted.  https://www.selleckchem.com/products/PP242.html  Complete resection and en-bloc resection rates were considered as the primary outcome measures. The secondary outcome measure was the pooled estimate of complications.
 
  nine studies including 301 patients with 305 lesions were finally included. The pooled estimate of en-bloc resections was 95.1 % (95 % CI 88.9-97.9 %), Cochran's Q-test, p = 0.151, and the weighted pooled rate (WPR) for complete resection was 97.9 % (95 % CI 93.6-99.3 %), Cochran's Q-test, p = 0.778. In addition, the pooled estimate of gas-related complications was 8.7 % (95 % CI 4.6-15.9 %), Cochran's Q-test, p = 0.057. The pooled estimate for mucosal laceration was 4.2 % (95 % CI 2.2-7.9 %), Cochran's Q-test, p = 0.572. The pooled estimate for delayed bleeding was 2.1 % (95 % CI 0.9-4.8 %), Cochran's Q-test, p = 0.985. The pooled estimate of inflammation-related complications was 8.6 % (95 % CI 5.2-13.9 %), Cochran's Q-test, p = 0.308.
 
  STER is an effective and safe technique for removing gastric SMTs with low complications, and complications, when encountered, can be treated conservatively.
 STER is an effective and safe technique for removing gastric SMTs with low complications, and complications, when encountered, can be treated conservatively.The case was an 86-year-old male with multiple cardiovascular comorbidites, including anticoagulated atrial fibrillation, who underwent a colonoscopy due to acute lower gastrointestinal bleeding and anemia. Colonoscopy only showed some small angiodysplasias in the cecum. A few hours later, the patient presented with abdominal pain and hemodynamic instability. An abdominal computed tomography was performed, which showed a splenic laceration and hemoperitoneum. An expectant attitude was decided, with a good evolution from the abdominal point of view. There was no sign of active splenic bleeding in a control computed tomography. However, he developed decompensated heart failure and finally died.