Objective The main purpose of our study has been to establish a link between the administration of intravenous fluids during Labor and the weight loss experienced by infants during hospitalization.Methods We conducted a retrospective observational study using a descriptive and comparative method. We studied 150 records of patients who gave birth at term (low-risk pregnancy) of a single healthy new born with breastfeeding in a university hospital center between 1 January 2016 and 31 July 2016. Maternal, obstetrical and neonatal characteristics were registered to determine the influence of vascular filling by univariate and multivariate analysis and identified factors that may lead to increase neonatal weight loss.Results One hundred and fifty mother-child couples were studied. Newborns whom mothers received at least 1500 mL of solute during Labor lose significantly more weight until the third day of life (p  less then  .001) compared to women who received less than 1500 mL, also observed for neonatal weight loss greater than 8% (p = .043). In addition, the obstetrical factors most significantly associated with an increase in the volume of solute injected were the duration of Labor (p  less then  .001), the administration of oxytocin (p  less then  .001), epidural analgesia (p = .01) and emergency cesarean section during Labor (p  less then  .001).Conclusion We found a link between vascular volume injected during Labor and increased risk of neonatal weight loss. Taking this factor into account when monitoring Labor in the birth room is essential to prevent and adapt neonatal management in the event of excessive weight loss. Influence of intrapartum maternal fluids on weight loss in breastfed newborns.Background Caffeine is routinely used in preterm infants for apnea of prematurity. Preterm infants are usually monitored for 5 days after discontinuation of caffeine to assess for possible recurrence of apnea. Our objective was to determine if the serum concentration of caffeine decreases to a subtherapeutic level 5 days after its discontinuation.Methods This is a retrospective analysis of caffeine levels after the drug was discontinued in preterm neonates (birth weight ≤1500 g) born between January 2010 and June 2017. The primary outcome was the proportion of infants with therapeutic levels of caffeine 5 days after the drug was stopped.Results Caffeine levels were measured in 353 samples from 280 infants (birth weight 1246 ± 390 g and gestational age 29.2 ± 2.4 weeks) after discontinuation of the drug. Five and more days after discontinuation of caffeine, 29.3% (82/280) of the infants had caffeine levels ≥5 mg/L. Approximately 41% (75/181) of the caffeine levels measured between 5 and 7 days and 18% (17/95) between 8 and 10 days were ≥5 mg/L. A caffeine dose of >5 mg/kg/day when discontinued was associated with the caffeine level of ≥5 mg/L (OR 2.3, 95% CI 1.28-4.13, p = .005).Conclusions Preterm infants treated with caffeine frequently had therapeutic levels of caffeine 5-10 days after discontinuation of the drug. The infants receiving higher doses were more likely to have a therapeutic level of caffeine 5 days after stopping the medication. Preterm infants should be monitored for recurrence of apnea for more than 5 days after stopping caffeine or levels should be monitored prior to discharge.Background Pregnancy is a metabolic state which demands increased iron bioavailability. While in preeclampsia, due to the placental vascular events there is an iron surplus environment along with inflammation and placental hypoxia. Routinely in India iron is supplemented to all pregnant women irrespective of their general physical condition. Hepcidin a regulator of iron metabolism protects the cells from iron mediated cytotoxicity.Objective To find out whether hepcidin gets induced as a protective mechanism in preeclampsia patients in order to combat the environment of iron overload, oxidative stress, and endothelial dysfunction.Methods A cross-sectional study with follow up was carried out in a South Indian Tamil population. Forty healthy pregnant women and forty preeclampsia patients in the gestational age 32 ± 4 weeks were recruited (n = 80). Biochemical analysis to assess the serum levels of the following were carried out (1) indices of iron homeostasis - serum iron, ferritin, transferrin, hepcidin, (2) es scenario may be viewed as a protective mechanism to combat the iron overload mediated cytotoxicity.Background Iron supplementation is widely recommended for all pregnant women, irrespective of their iron status. But providing excess iron to nonanemic pregnant women can result in iron overload, which may lead to oxidative stress and inflammation.Objectives To assess the differential effect of iron supplementation on hematological parameters, oxidative stress, and inflammation in nonanemic and anemic pregnant women.Methods Forty nonanemic and forty anemic pregnant women were recruited at 12 weeks of gestation.  https://www.selleckchem.com/products/sd-208.html  The study subjects were supplemented with iron (60 mg/day for nonanemic pregnant women and 120 mg/day for anemic pregnant women). Fasting state blood samples were collected at 12 and 28 weeks of gestation.Results Malondialdehyde (MDA)/total antioxidant status (TAS) ratio (MDA/TAS) and high-sensitivity C-reactive protein (hsCRP) were significantly higher in anemic pregnant women before iron supplementation. Iron supplementation to the anemic pregnant women resulted in significant improvement in the hematological profile and ferritin levels. Further, the iron supplementation caused a significant reduction in hsCRP levels although the MDA/TAS ratio remained unaltered. Iron supplementation to nonanemic pregnant women resulted in a significant increase in the levels of MDA/TAS ratio and hsCRP, but there were no changes in hematological profile and serum ferritin levels.Conclusion Prophylactic iron supplementation in nonanemic pregnant women increased oxidative stress and inflammation. However, in anemic pregnant women, iron supplementation was found to be beneficial as it improved hematological status and decreased inflammation without affecting oxidative stress.