To assess the influence of multiple uses on the cyclic flexural fatigue and torsional resistance of Reciproc R25 (REC) instruments. 256 canals (2 for each mandibular molar) were prepared using Reciproc R25 instruments. A total of 96 25-mm-long Reciproc R25 instruments were divided in six groups (n=8) on the basis of different number of canal shaped new instruments (control group), 1, 2, 3, 4 or 6 canals shaped during simulated clinical use for other groups respectively. Sixteen files were used for each of the six groups (8 instruments for cyclic fatigue test and 8 ones for torsional test). Times to fracture (TtF) for cyclic fatigue and ultimate torsional strength and angle of rotation to fracture for torsional resistance were recorded. Data were statistically evaluated by the analysis of variance (ANOVA) with P<.05. As for cyclic fatigue resistance, there was no significant difference between new REC and REC used in one, two and three canals respectively (P>.05). REC used in four and six canals showed significant lower times to fracture when compared with other groups (P<.05) with REC used in six canals showing the significant lowest times to fracture (P<.05). Considering torsional resistance parameters, no significant difference was observed between the new and used instruments (P>.05). REC25 files showed a significant decrease in cyclic fatigue resistance only when used in four or more molar canals while their torsional behavior was not affected by multiple uses. REC25 files showed a significant decrease in cyclic fatigue resistance only when used in four or more molar canals while their torsional behavior was not affected by multiple uses. The aim of this study is to highlight the connection between orthodontic difficulty before surgical treatment and in the transient malocclusion as evaluated by the mean of the ICON score and total treatment time in SFA. For each patient, the ICON score was evaluated pre-operatively and on the 3rd post-operative day in order to assess the orthodontic difficulty of pre-surgical occlusion and the transient malocclusion. Our group of patients at the preoperative stage showed score values between hard and very hard with only one patient scored as "easy" and nine "medium" patients. All scores lowered after surgical treatment. This confirms that the surgery first approach can change a malocclusion from not orthodontically treatable to an orthodontically treatable one. In our study, this was objectified by improvements in the ICON score. In the conventional three-phase approach of orthognathic surgery the total treatment time found in literature is around 18-36 months. In our study, even the most difficult cases do not have a duration of more than 15 months This demonstrates that the surgery-first approach can reduce the total treatment time even in more severe cases. Our group of patients at the preoperative stage showed score values between hard and very hard with only one patient scored as "easy" and nine "medium" patients. All scores lowered after surgical treatment. This confirms that the surgery first approach can change a malocclusion from not orthodontically treatable to an orthodontically treatable one. In our study, this was objectified by improvements in the ICON score. In the conventional three-phase approach of orthognathic surgery the total treatment time found in literature is around 18-36 months. In our study, even the most difficult cases do not have a duration of more than 15 months This demonstrates that the surgery-first approach can reduce the total treatment time even in more severe cases.Technological development has interested most of the dentistry's branches leading to the use of other medical technologies non previously involved in dental practice. This study aims to evaluate the potential role of non-invasive imaging techniques in oral pathology workflow. Optical coherence tomography has been described by several authors as a promising aid for differential diagnosis of autoimmune diseases and to detect epithelial subversion of the oral mucosa before the clinical manifestation of oral mucositis. High-frequency ultrasound offers the chance to assess lesional dimensions both in benign and malignant lesions with a high dimensional reliability compared with histopathology. Reflectance confocal microscopy seems to be helpful in the early detection of cytological changes due to its high resolution, suggesting a more interesting role in the analysis of malignant lesions. The study presented highlighted the potential role of noninvasive in vivo imaging although further studies are needed for the further validation of these techniques. The objective of this study was to retrospectively evaluate the success and survival rate of implants with different types of prosthetic connections inserted in the posterior maxilla in native bone or in sinuses previously grafted with different biomaterials. A total of 310 implants inserted in 113 patients were evaluated, 87 of which were inserted in association with grafted maxillary sinuses (56 morse taper (MT) implants and 31 external hexagon (EH) implants) in 37 patients, and 223 implants were inserted in native bone areas (112 MT and 111 EH implants) in 76 patients. Peri-implant clinical analyses were performed (bleeding on probing, probing depth, clinical insertion level, peri-implant marginal level, and the presence of mobility or suppuration), and the radiographic bone level was evaluated. Two implants were lost, yielding a survival rate of 99.35 %. The MT implants had lower probing depths and peri-implant bone levels than the EH implants in both grafted areas and native bone areas (p <0.05). https://www.selleckchem.com/products/skf96365.html No statistically significant differences in any parameter evaluated were found between implants inserted in native bone and those inserted in grafting areas. EH implants inserted in native bone areas showed higher periimplantitis rates. It can be concluded that the MT implants connection reduce periimplant bone loss, but implants inserted in maxillary sinuses previously grafted with osteoconductive biomaterials do not predispose patients to peri-implant bone loss. It can be concluded that the MT implants connection reduce periimplant bone loss, but implants inserted in maxillary sinuses previously grafted with osteoconductive biomaterials do not predispose patients to peri-implant bone loss.