Objective To investigate the epidemiological profile of snakebite accident cases, their determinants and risk areas in the state of Tocantins. Methods This was an ecological study using data from the Notifiable Health Conditions Information System, from 2007 to 2015. Multiple linear regression and the Mann-Whitney and Kruskal-Wallis tests were used. Results A total of 7,764 snakebite accidents were reported (incidence 62.1/100,000 inhab.; lethality 0.5%). The variables associated with snakebite were population density (Coeff.=1.36, 95%CI 0.72;1.99), farming work (Coeff.=0.02, 95%CI 0.01;0.03), municipal human development index (Coeff.=2.99 - 95%CI 0.60;5.38), area planted with cassava (Coeff.=8.49 - 95%CI 1.66;15.32), indigenous population (Coeff.=0,02 - 95%CI 0.00; 0.04), proportion of illiterate people (Coeff.=4.70 - 95%CI 0.61;8.79) and employed people (Coeff.=3.00 - 95%CI 0.93;5,06), which together accounted for 64.48% of the variation. The high-risk areas were Amor Perfect, Cantão, Cerrado Tocantins Araguaia and Mid-North Araguaia health regions. Conclusion Municipal socioeconomic and demographic aspects were associated with snakebites.Three species (2 new) of Urocleidoides are described and/or reported from the gills of Schizodon fasciatus and Laemolyta proxima (Anostomidae) from the Jari River in the eastern Brazilian Amazon. Urocleidoides jariensis n. sp. presents a sclerotized, tubular, spiral male copulatory organ (MCO) with one counterclockwise coil, a circular sclerotized tandem brim associated with the base of the MCO; a heavily sclerotized, funnel-shaped vaginal vestibule; and a broadly V-shaped ventral bar with anteromedial constriction and enlarged ends. Urocleidoides ramentacuminatus n. sp. has a sclerotized, tubular, spiral MCO with one counterclockwise coil; an accessory piece with a hook-shaped distal portion; and a dorsal anchor with a short, straight shaft; anchor point with ornamentation as sclerotized shredded filaments. Urocleidoides paradoxus is reported for the first time parasitizing S. fasciatus.[This corrects the article DOI 10.1590/s1984-29612020034.].Metachirus myosuros is a marsupial species widely distributed in South America. Despite this, there is a lack of knowledge about its helminth parasites and helminth community structure. The aims of this study were to describe the species composition and determine the parasitological parameters of helminth communities of M. myosuros in preserved areas of the Atlantic Forest, Igrapiúna, Bahia state, northeastern Brazil. Parasites were searched from 19 specimens of this marsupial (18 were infected with at least one species), counted and identified. Ten species of helminth parasites were obtained 7 nematodes, 2 platyhelminths and 1 acanthocephalan. The most abundant species were Aspidodera raillieti, Cruzia tentaculata, Physaloptera mirandai and Viannaia conspicua (Nematoda). These species were also the only dominant ones in the component community. Male hosts had higher prevalence of P. mirandai and greater abundance of V. conspicua. We observed a relationship between host body size and helminth abundance in both male and female hosts, and between host body size and helminth species richness in female hosts. This was the first study to analyze the helminth fauna and helminth community structure of M. myosuros. This was the first report of occurrences of A. raillieti and Didelphonema longispiculata in M. myosuros.Objective To describe the implementation of a care protocol based on rapid response teams, for management and resolution of bleeding.  https://www.selleckchem.com/products/Temsirolimus.html  Methods A hospital protocol called Hemorrhage Code (Code H) was devised and developed. In a flow line, a multidisciplinary team provides comprehensive, fast and effective care to the patient with a severe hemorrhagic condition. In another flow line, professionals based at the hospital pharmacy focus on identifying patients at risk of bleeding, to avoid this event. Several hospital professionals and sectors were trained, each with specific roles, ensuring full support to the medical and nursing staffs. Results After implementing this protocol, we were able to significantly reduce the number of catastrophic events related to failure in bleeding management. Conclusion Code H is an example of a value-based medicine and precision medicine project by delivering comprehensive and multidisciplinary care, in addition to point-of-care testing introduced in clinical practice, optimizing patient safety and care practices at the hospital. Furthermore, it will be possible to minimize the risk of lawsuits for the hospital and physicians, as well as rationalizing resources with benefits for administrators and payers.Adiponectin, among other diverse adipokines, is produced in greater quantity and has an effect on the adipose tissue and other tissues in the body. Adiponectin plays three main roles regulatory metabolic and sensitizing function of insulin in the liver and muscles; it acts as an anti-inflammatory cytokine and in vascular protection, besides important cardiac protection in the presence of ischemia-reperfusion syndrome. Since many situations resulting from traumatic accidents or pathologies are due to cell damage caused by ischemia-reperfusion syndrome, it is relevant to study new therapeutic alternatives that will contribute to reducing these lesions. The objective of this study is to carry out a literature review on the role of adiponectin in ischemia-reperfusion syndrome.Purpose To synthesize and characterize poly(hydroxybutyrate) (PHB) and norbixin membranes to evaluate them for genotoxicity in rats and wound healing in mice by histological staining. Methods For the evaluation of genotoxicity, male rats ( Rattus novegicus ) were divided into three groups (n= 5) 5% PHB/Norbixin membrane introduced into the peritoneum by laparotomy; B - negative control; C - positive control (intraperitoneal dose of cyclophosphamide 50 mg/kg). For the evaluation of biocompatibilty, a cutaneous wound was induced on the back of males mice ( Mus musculus ) divided into two experimental treatment groups control and membrane that underwent euthanasia after 7 and 14 days treatment. Statistical analysis ware made by One Way Anova post hoc Tukey Test (p less then 0.05). Results Regarding the incidence of polychromatic erythrocytes, there was no difference between negative control and 5% PHB/Norbixin membrane; however, when compared to the positive control represented by cyclophosphamide, there was a significant difference (p less then 0.