https://www.selleckchem.com/products/tp-0903.html The influence of the flexural modulus of prefabricated posts on the fracture resistance of endodontically treated teeth is unclear. The purpose of this invitro study was to evaluate the influence of post material and post diameter on the fracture resistance of endodontically treated mandibular premolars. In addition, the influence of tooth substance loss was evaluated by comparing 1 with 2 residual dentinal walls. Sixty-four extracted mandibular first premolars were endodontically treated and divided into 8 test groups (n=8) based on the number of residual walls (1 or 2), post material (glass fiber or titanium) and post diameter (International Standards Organization [ISO] 70 or ISO 90). After luting the posts, the specimens received a composite resin core and a crownpreparation with a 2-mm ferrule. Cast Co-Cr crowns were cemented with glass ionomer cement. After 1 200 000 mastication cycles with a load of 49 N and simultaneous thermocycling (5 °C-55 °C), specimens were quasistatically loaded at 30 degrees to the longitudinal axis of the tooth until fracture. Fracture loads were analyzed by using 3-way ANOVA (α=.05). Fracture modes were examined with a stereomicroscope at×25 magnification and recorded. Fracture loads ranged from 954 ±35 N (1 residual wall-glass fiber-ISO 70) to 1286 ±202 N (1 residual wall-glass fiber-ISO 90). Titanium posts showed a statistically significant higher fracture resistance than glass fiber posts. A statistically significant increase in fracture resistance was also observed with increasing post diameter. However, no significant difference was found with respect to the number of residual walls (P>.05). Teeth restored with titanium posts exhibited higher fracture resistance than teeth restored with glass fiber posts, especially when smaller diameter posts were used. Teeth restored with titanium posts exhibited higher fracture resistance than teeth restored with glass fiber posts, especially