https://www.selleckchem.com/products/ag-825.html Background Klippel-Trenaunay-Weber syndrome (KTWS) is characterized by the presence of a combined vascular malformation of capillaries, veins, and lymphatic vessels, congenital venous abnormalities, and limb hypertrophy. Its association with neurovascular abnormalities is infrequent, and the presence of intracranial arteriovenous malformations (AVMs) is extremely rare. Case description We report a case of a 48-year-old male diagnosed with KTWS who spontaneously presented with a cerebral hemorrhage. CT scan and angio-CT studies revealed bleeding associated with AVM rupture. In the conventional arteriography study, ten small ( less then 1 cm)AVM were observed. The patient presented a good clinical recovery. These multiple small lesions were not considered susceptible to surgical or endovascular treatments. Therefore, all lesions were treated with Gamma-Knife stereotactic radiosurgery since it attains the highest dose drop and minimal irradiation of the healthy parenchyma. One year after the treatment, the lesions have shrunk. Conclusions Cerebral AVMs are extremely rare in KTWS cases; however, their presence can have serious consequences if they are treated. We find it advisable to include brain imaging tests, such as nuclear magnetic resonance imaging, to diagnose and monitor KTWS. Furthermore, Gamma Knife may be useful when multiple AVMs are present.Background Brain metastasis is a rare event in patients with hepatocellular carcinoma (HCC). The combination of an anti-programmed death 1 (PD-1) inhibitor and an anti-VEGF drug provides therapeutic opportunities for refractory patients. So far, there is no data on the efficacy of these combined therapies for patients with HCC brain metastasis. Case description We herein report a case of a 31-year-old man diagnosed with HCC brain metastasis. First, he underwent left liver resection and cholecystectomy and recovered well postoperatively. The postoperative pathologic finding