[This corrects the article DOI 10.1155/2020/8184607.].
  The purpose of this study was to evaluate the effect of genetic-environmental interaction on myopia in Chinese children aged 6 to 9 years.
 
  Students had the physical examination and were required to provide basic demographic information. Their families were asked to fill in a questionnaire concerning factors related to myopia. Multiple regression analysis was performed, and adjusted risk ratio values were calculated to assess the role between gene and environment. Value of the environmental and genetic index (EGI) was calculated to demonstrate the effect of genetic-environmental interaction on myopia.
 
  The prevalence of myopia maintained at a high level. EGI was calculated as 0.125 suggesting that genetic factors may play the 12.5% role in the formation of myopia and environmental factors may play a role of 87.5% in the formation of myopia.
 
  For young pupils aged 6 to 9 years, myopia prevalence maintained at a high level, and duration of homework time and staring at electronic screen were the strongest factors associated with myopia. The calculated value of EGI was low, which suggests that environmental factors may play the leading role in the formation of myopia. A long-term follow-up research to improve the accuracy value of EGI is our next job.
 For young pupils aged 6 to 9 years, myopia prevalence maintained at a high level, and duration of homework time and staring at electronic screen were the strongest factors associated with myopia. The calculated value of EGI was low, which suggests that environmental factors may play the leading role in the formation of myopia. A long-term follow-up research to improve the accuracy value of EGI is our next job.Huntington's disease (HD) is a fatal, inherited neurodegenerative disease that causes neuronal death, particularly in medium spiny neurons. HD leads to serious and progressive motor, cognitive and psychiatric symptoms. Its genetic basis is an expansion of the CAG triplet repeat in the HTT gene, leading to extra glutamines in the huntingtin protein. HD is one of nine genetic diseases in this polyglutamine (polyQ) category, that also includes a number of inherited spinocerebellar ataxias (SCAs). Traditionally it has been assumed that HD age of onset and disease progression were solely the outcome of age-dependent exposure of neurons to toxic effects of the inherited mutant huntingtin protein. However, recent genome-wide association studies (GWAS) have revealed significant effects of genetic variants outside of HTT. Surprisingly, these variants turn out to be mostly in genes encoding DNA repair factors, suggesting that at least some disease modulation occurs at the level of the HTT DNA itself. These DNA repair proteins are known from model systems to promote ongoing somatic CAG repeat expansions in tissues affected by HD. Thus, for triplet repeats, some DNA repair proteins seem to abandon their normal genoprotective roles and, instead, drive expansions and accelerate disease. One attractive hypothesis-still to be proven rigorously-is that somatic HTT expansions augment the disease burden of the inherited allele. If so, therapeutic approaches that lower levels of huntingtin protein may need blending with additional therapies that reduce levels of somatic CAG repeat expansions to achieve maximal effect.
  Microprocessor knee analyses to date have been primarily limited to microprocessor knees as a category rather than comparisons across different models. The purpose of the current analysis was to compare outcomes from four common knee models.
 
  A retrospective analysis of clinical outcomes was performed. Outcomes for functional mobility, quality of life, satisfaction with amputee status, and injurious falls were compared. Specific knee types represented were C-Leg (Ottobock), Orion (Blatchford), Plié (Freedom Innovations), and Rheo (Össur).
 
  Outcomes from 602 individuals were included. No significant differences were noted for functional mobility (H = 2.91, p = 0.406) or satisfaction (H = 4.43, p = 0.219). For quality of life, differences existed for C-Leg versus Plié (p = 0.010). For injurious falls, C-Leg (χ
  
   = 10.99, p < 0.001) and Orion (χ
  
   = 4.34, p = 0.037) resulted in significantly reduced injurious falls compared to non-microprocessor knee users. C-Leg (H = 19.63, p < 0.001) and Plié (H = 14.04, p = 0.003) users saw declines with advanced aging.
 
  Our data indicate relative parity among the 4 microprocessor knees with regard to functional mobility and satisfaction. In contrast to mobility, neither satisfaction nor quality of life values reflected declines with aging.  https://www.selleckchem.com/products/MLN8237.html  Finally, when compared to non-microprocessor knees, significant differences were observed across the microprocessor knee types in relation to the reduction of injurious falls.Keywords MPK, mobility, quality of life, falls, amputee, outcomes.
 Our data indicate relative parity among the 4 microprocessor knees with regard to functional mobility and satisfaction. In contrast to mobility, neither satisfaction nor quality of life values reflected declines with aging. Finally, when compared to non-microprocessor knees, significant differences were observed across the microprocessor knee types in relation to the reduction of injurious falls.Keywords MPK, mobility, quality of life, falls, amputee, outcomes.
  Walking with a prosthesis while performing secondary tasks increases demand on cognitive resources, compromising balance and gait. This study investigated effects of a secondary task on patterns of brain activity and temporospatial gait parameters in individuals using a prosthesis with or without a microprocessor-controlled prosthetic knee(MPK) and controls.
 
  A cross-sectional study with repeated measures was performed. Twenty-nine individuals with amputations and 16 controls were recruited. Functional near-infrared spectroscopy was used to evaluate changes in oxygenated and de-oxygenated haemoglobin in the prefrontal cortex and temporospatial variables during single-and dual-task walking.
 
  Differences in brain activity were observed within the MPK-group and controls without changes in temporospatial parameters. The Trail-Walking test was associated with highest levels of brain activity in both groups. No differences were observed between single- and dual-task walking in the non-MPK-group (p > 0.05). The Non-MPK and the MPK-group recorded higher levels of brain activity than controls during single-task walking and poorer results on temporospatial variables compared to controls.