https://www.selleckchem.com/products/suzetrigine.html Strong CYP3A induction, in contrast, resulted in mean decreases by 57-90% (mean decrease in midazolam exposure 86%). Namely, the magnitude of the observed induction effects varied from weak to strong. Our data might provide an impetus to revisit the currently applied clinical recommendations for oral contraceptives, especially for levonorgestrel and norethindrone containing products, and they might give an indication as to which progestin could be used, if requested, by women taking weak CYP3A inducers - although it is acknowledged that the exact exposure-response relationship for contraceptive efficacy is currently unclear for most progestins. This article is protected by copyright. All rights reserved.The soaring demand for acrylic nails has resulted in a rapid increase in the frequency of allergic contact dermatitis (ACD) to (meth)acrylates1,2 . However, traditional nail varnish remains widely used. Nail varnish is a mixture of film formers and include nitrocellulose, adipic acid/neopentyl glycol/trimellitic anhydride copolymer (AA), and phthalic anhydride/trimellitic anhydride/glycols copolymer (PA). This article is protected by copyright. All rights reserved.The in vitro affinity of a compound for its target is an important feature in drug discovery, but what remains is how predictive in vitro properties are of in vivo therapeutic drug exposure. We assessed the relationship between in vitro potency and clinically efficacious concentrations for marketed small molecule drugs (n=164) and how they may differ depending on therapeutic indication, mode-of-action, receptor type, target localisation and function. Approximately 70 % of compounds had a therapeutic unbound plasma exposure lower than in vitro potency; the median Ratio of exposure in relation to in vitro potency was 0.32, and 80% had Ratios within 0.007 and 8.7. We identified differences in the in vivo-to-in vitro potency Ratio between indications, mode-o