Costs and outcomes were discounted (3%/year).
 
  Higher cost/patient (€177,618 vs €151,434) and greater QALYs (5,70 vs 4,62) were obtained with GO+SOC vs SOC. The ICUR was €24,203/QALY gained.
 
  This simulation suggests that GO + SOC could be a cost-effective option for treatment of patients with 
  AML in first line.
 This simulation suggests that GO + SOC could be a cost-effective option for treatment of patients with de novo AML in first line.
  Bacterial urinary tract infection (BUTI) is the commonest urinary tract infection among people living with human immunodeficiency virus (PLHIV). It causes significant morbidity in this vulnerable group. Immunosuppression due to HIV can mask the signs and symptoms of infection leading to asymptomatic disease. There is limited evidence in Tanzania regarding BUTI and PLHIV. This study aimed to determine the prevalence, etiology, risk factors and susceptibility pattern of isolates causing asymptomatic UTI in PLHIV at Kilimanjaro Christian Medical Centre (KCMC).
 
  This cross-sectional study was conducted from July to September 2020 at Kilimanjaro Christian Medical Centre (KCMC) hospital. A questionnaire was used to collect social demographic data from patients' files together with necessary information required by this study. Urine samples were obtained from participants for urinalysis and urine culture and sensitivity. Data from 300 adults aged ≥18 years were analyzed using Statistical Package for Social Sciencia have BUTI. Presence of nitrites in urine is an important biomarker associated with BUTI. About two third of the isolates were Gram-positive bacteria, and nearly half of all isolates showed MDR to commonly used antibiotics.
  An increasing frequency of antibiotic resistance has been observed in both clinical and environmental 
  isolates in recent years. However, there are still very few in-depth studies regarding the role of plasmids in the antibiotic resistance of 
  .  https://www.selleckchem.com/products/Sunitinib-Malate-(Sutent).html  Hence, we investigated the molecular and functional characterization of a multidrug-resistant plasmid encoding an NDM-like metallo-β-lactamase, AFM-1, in the clinical 
  isolate SS332.
 
  The minimum inhibitory concentrations (MICs) of 24 antibiotics against 
  SS332 were measured by the agar dilution method. The genome of 
  SS332 was sequenced with PacBio and Illumina platforms. Six plasmid-borne antimicrobial resistance genes were chosen for cloning, including 
  
  , 
  
  , 
  (E), 
  (E), 
  , and 
  . Phylogenetic analysis, amino acid sequence alignment, and comparative genomic analysis were performed to elucidate the active site requirements and genetic context of the 
  
  gene.
 
  SS332 showed high levels of resistance to 15 antibiotics, especially those with tional and associated with novel ISCR19-like elements. This fact indicated the risk of spread of bla AFM-1 genes and ISCR19-like elements.
  Multidrug-resistant (MDR) 
  is an important nosocomial pathogen causing urinary tract infection, and the reapplication of nitrofurantoin (NIT) in the clinic has attracted great attention. This study aims to explore the NIT resistance mechanisms and epidemiological characteristics of 
  clinical isolates.
 
  A total of 633 
  clinical isolates was obtained from urine samples in a clinical teaching hospital during 2017-2018. Among them, 40 NIT-resistant strains, and a similar number of -intermediate and -susceptible strains were isolated. The minimum inhibitory concentrations (MICs) of NIT were detected by agar dilution method. The prevalence and mutations of nitroreductase-encoding genes 
  and 
  were explored by polymerase chain reaction (PCR), followed by efflux pump inhibition test and quantitative real-time PCR (qRT-PCR) to investigate the resistance mechanisms of NIT. Furthermore, the epidemiological characteristics were detected by multilocus sequence typing (MLST).
 
  The carrying rates of nitroreductpidemiological characteristics analysis.
  The importance of microRNAs (miRs) has been documented in infections. This study estimated the role of miR-340-5p in 
  (Mtb)-infected alveolar type II cells.
 
  The microarray of GEO database was analyzed to find the differentially expressed miRs caused by Mtb infection, and miR-340-5p was selected as the research object. The effects of Mtb infection on A549 cells were studied by MTT, CFU, EdU, flow cytometry and ELISA assays. miR-340-5p expression was altered in Mtb-infected A549 cells. The downstream target of miR-340-5p was found by bioinformatics analysis and verified by the rescue experiment. The pathways regulated by miR-340-5p and its target gene were further studied.
 
  Mtb infection suppressed the activity of A549 cells and promoted the release of inflammatory factors. Mtb infection inhibited miR-340-5p expression. Overexpression of miR-340-5p enhanced the resistance of A549 cells to Mtb infection. Moreover, miR-340-5p targeted TMED7. Overexpression of TMED7 reversed the protective effect of miR-340-5p on Mtb-infected A549 cells. miR-340-5p inhibited the activation of NF-κB by targeting TMED7.
 
  miR-340-5p inhibits the activation of NF-κB by targeting TMED7, thus alleviating the injury of A549 cells caused by Mtb infection. This study may offer a novel approach to Mtb infection.
 miR-340-5p inhibits the activation of NF-κB by targeting TMED7, thus alleviating the injury of A549 cells caused by Mtb infection. This study may offer a novel approach to Mtb infection.
  is one of the main causative agents of hospital-acquired (HA) infections. In Mexico, information about the characteristics of clinical 
  isolates is limited. Our aim was to characterize 
  strains obtained from blood cultures of paediatric patients treated in a tertiary care hospital.
 
  We analysed 249 
  isolates over the period from 2006 to 2019, and their resistance profiles were determined. The isolates were classified into methicillin-resistant 
  (MRSA) or methicillin-sensitive 
  (MSSA). Staphylococcal cassettes chromosome 
  (SCC
  ) were detected. Virulence genes (
  and 
  ) were amplified, and their clonal relationships were established by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST) and clonal complex (CC) typing. We reviewed one hundred medical files to collect clinical information.
 
  Thirty-eight percent of the isolates were MRSA and showed an expanded profile of resistance to other non-beta-lactam antibiotics, while MSSA strains presented a reduced resistance profile.