rements. This may be due to the small index of refraction change at the cornea-aqueous interface. While keratometric indices from the 2 devices are highly correlated, measurements taken using SS-OCT and S-P devices were not interchangeable.The degree of visual disturbance associated with a particular model of intraocular lens (IOL) depends upon several factors, including IOL optic, material, and mechanics. Characterization of visual disturbance profiles is paramount for informing clinical IOL selection. While many studies evaluating presbyopia-correcting IOLs include subjective assessment of visual symptoms, the types of patient-reported outcome measures (PROMs) used to capture these outcomes are inconsistent across studies, complicating data contextualization. Furthermore, some tools produce more meaningful results than others. This review presents a discussion on the scientific literature published on the subjective and semi-objective (halo and glare simulator, light-distortion analyzer, vision monitor, and halometers) methods used to assess visual disturbances in patients implanted with trifocal or extended-depth-of-focus IOLs, highlighting their advantages and limitations. It underscores the importance of between-study comparisons and the need for standardized PROMs in clinical IOL research to provide more accurate information for IOL selection.
  To determine the ability to differentiate between normal eyes and clinically unaffected eyes of patients with highly asymmetric keratoconus using a Scheimpflug/Placido device SETTING Tel Aviv Sourasky Medical Center and Enaim Medical Center, Israel.
 
  Retrospective case-control.
 
  Imaging from a combined Scheimpflug/Placido device (Sirius, C.S.O.) was obtained from 26 clinically unaffected eyes of patients with frank keratoconus in the fellow eye, and 166 eyes from 166 patients with bilaterally normal corneal examinations that underwent uneventful corneal refractive surgery with at least 1 year of follow-up. Receiver operating characteristic curves were produced to calculate the area under the curve (AUC), sensitivity, and specificity of 60 metrics, and finally a logistic regression modeling was employed to determine optimal variables to differentiate populations.
 
  The most predictive individual metric was the posterior cornea inferior-superior (I-S) ratio, with an AUC of 0.862.  https://www.selleckchem.com/products/sj6986.html  A combination model of 4 metrics (posterior cornea I-S ratio in the central 3 mm, thinnest pachymetry coordinate on the x horizontal axis, posterior asymmetry and asphericity index, corneal volume) yielded an AUC of 0.936, with a sensitivity/specificity pair of 92.3%/87%. Variables related to maximum elevation were not found significant.
 
  Using a combination of metrics from a combined Scheimpflug/Placido device, a practical model for discrimination between clinically normal eyes of patients with highly asymmetric keratoconus and normal eyes was constructed. Variables related to pachymetry and posterior cornea asymmetry were the most impactful.
 Using a combination of metrics from a combined Scheimpflug/Placido device, a practical model for discrimination between clinically normal eyes of patients with highly asymmetric keratoconus and normal eyes was constructed. Variables related to pachymetry and posterior cornea asymmetry were the most impactful.
  To characterize intraocular pressure (IOP) response following treatment with dexamethasone intraocular suspension 9%) vs placebo (vehicle) injection or topical prednisolone acetate 1% and to identify factors correlating with increased intraocular pressure (IOP) following cataract surgery.
 
  Data were pooled from two phase 3 clinical trials of patients undergoing routine cataract surgery.
 
  Randomized double-blind study and open-label study.
 
  Subjects were randomized to treatment with dexamethasone intraocular suspension or placebo in the double-blind study 1, and dexamethasone intraocular suspension or topical prednisolone acetate in the open-label study 2. Subjects who experienced ≥10 mm Hg, 15 mm Hg, or 20 mm Hg postoperative IOP increase from baseline were stratified by baseline IOP. Univariate and multivariate logistic regression models of patient variables were applied to identify independent risk factors predictive of IOP elevation ≥10 mm Hg or 15 mm Hg.
 
  The study comprised 414 subjects. Dexamethase intraocular suspension was associated with IOP elevation patterns comparable to topical prednisolone. High myopia, higher baseline IOP, and male sex were significant predictors of postoperative IOP elevation in this cohort.A 76-year-old man with a medical history of type 2 diabetes, hypercholesterolemia, and coronary artery disease presented with blurred vision in the right eye. His ocular history was significant for cataract surgery with posterior chamber intraocular lens (PC IOL) implantation in both eyes 3 years prior to presentation. His specific ocular complaints included blurred vision, whiteout visual episodes lasting 20 minutes, and intractable glare in the right eye. Of note, the patient was on anticoagulation therapy due to a history of stroke.On examination, the corrected distance visual acuity (CDVA) was 20/50 in the right eye and 20/25 in the left eye with a manifest refraction of plano -0.50 × 70 degrees in the right eye and plano -050 × 170 degrees in the left eye. Pupils were round and reactive in both eyes. However, there was a 3+ relative afferent pupillary defect with a corresponding constricted confrontational visual field test in the right eye. The left eye was unremarkable. Intraocular pressure (IOP) measut an uneventful pars plana vitrectomy (PPV), endolaser, and SF6 gas. Unfortunately, the patient experienced redetachment 2 weeks later requiring C3F8 gas. At the 6-week IOP check, the patient was noted to have early central opacification of the IOL (). IOL opacification continued to progress and the vision declined to CDVA of 20/200 by 3 months postoperatively ().(Figure is included in full-text article.)(Figure is included in full-text article.)What is the next step in management for this patient given the comorbidities of an opacified IOL, advanced glaucoma, anticoagulation status, and diffuse 360 degrees transillumination iris defects?