Complete snow avalanche burial is associated with high mortality. The aim of this study was to assess the feasibility and incidence of organ retrieval in brain-dead donors following cardiorespiratory arrest due to avalanche burial and to evaluate the function of transplanted organs.
 
  The transplant registry of the Medical University of Innsbruck was searched for organ donors with a history of avalanche burial, and the function and survival of transplanted organs were assessed.
 
  Thirty-three organs were procured from eight donors and 31 organs (13 kidneys, 6 livers, 3 pancreases, 5 hearts, 4 lungs) were ultimately transplanted. Allograft and recipient 1-year survival were 100% and both initial and long-term graft function were good. Only one-third of all avalanche victims who died in the ICU with signs of irreversible hypoxic brain injury became organ donors.
 
  Initial experience from this retrospective study suggests that organs from brain-dead avalanche victims can be transplanted with good results. Starting a Donation after Circulatory Determination of Death program might be an option for increasing the number of organ donations from avalanche victims with irreversible hypoxic brain injury.
 Initial experience from this retrospective study suggests that organs from brain-dead avalanche victims can be transplanted with good results. Starting a Donation after Circulatory Determination of Death program might be an option for increasing the number of organ donations from avalanche victims with irreversible hypoxic brain injury.
  Brain death (BD) is associated with systemic inflammatory compromise, which might affect the quality of the transplanted organs. This study investigated the expression profile of cardiac microRNAs (miRNAs) after BD, and their relationship with the observed decline in myocardial function and with the changes induced by hypertonic saline solution (HSS) treatment.
 
  Wistar rats were assigned to sham-operation (SHAM) or submitted to BD with and without the administration of HSS. Cardiac function was assessed for 6h with left ventricular (LV) pressure-volume analysis. We screened 641 rodent miRNAs to identify differentially expressed miRNAs (DEMs) in the heart and computational and functional analysis were performed to compare the DEMs and find their putative targets and their related enriched canonical pathways.
 
  An enhanced expression in canonical pathways related to inflammation and myocardial apoptosis was observed in BD induced group, with two miRNAs, miR-30a-3p and miR-467f, correlating with the level of miRNA's on early and late cardiac allograft function must be investigated.Supplemental Visual Abstract; http//links.lww.com/TP/C210.
  The incidence, risks, and outcomes associated with pulmonary hypertension (P-HTN) in the kidney transplant (KTx) population are not well described.
 
  We linked U.S. transplant registry data with Medicare claims (2006-2016) to investigate P-HTN diagnoses among Medicare-insured KTx recipients (N=35,512) using billing claims. Cox regression was applied to identify independent correlates and outcomes of P-HTN (adjusted hazard ratio, aHR, 95%LCLaHR95%UCL), and to examine P-HTN diagnoses as time-dependent mortality predictors.
 
  Overall, 8.2% of recipients had a diagnostic code for P-HTN within 2 years preceding transplant. By 3 years posttransplant, P-HTN was diagnosed in 10.310.6%11.0 of the study cohort. After adjustment, posttransplant P-HTN was more likely in KTx recipients who were older (aHR for age >60 vs. 18-30 years 1.912.403.01) or female (aHR, 1.151.241.34), who had pretransplant P-HTN (aHR, 4.384.795.24), coronary artery disease (aHR, 1.051.151.27), valvular heart disease (aHR, 1.221.321.43), perification, and management strategies to improve outcomes in KTx recipients who develop P-HTN.
  Expedited partner treatment (EPT) is effective for preventing STI recurrence, but concerns about intimate partner violence and missed opportunities for HIV testing have limited its use in African settings.
 
  We conducted a pilot prospective evaluation of EPT among adolescent girls and young women (AGYW) accessing HIV pre-exposure prophylaxis in an implementation project in Kisumu, Kenya. Those with etiologic diagnosis of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) were treated and given the option of delivering STI medication and HIV self-test kits to their current sexual partner(s). At enrollment, we assessed their reasons for declining. Three months after they delivered medication and kits to the partner(s), we assessed their reasons for failing to deliver medication and kits to their partner and reported partner's reactions.
 
  Between September 2018 and March 2020, 63 AGYW were enrolled. The majority 59/63 (94%) accepted EPT and 50/63 (79%) partner HIVST.  https://www.selleckchem.com/products/TGX-221.html  Three-quarters (46/59) of those accepting EPT returned for the assessment visit with 41/46 (89%) successfully delivering medication to 54 partners, of whom 49/54 (91%) used it. Seventy percent (35/50) who took partner HIVST kits returned for the assessment with 80% (28/35) reporting providing kits to 40 partners, of whom 38/40 (95% ) used it. Reported barriers to EPT and partner HIVST uptake among women who declined included anticipated fear that their partner could become angry or violent, and loss of relationship.
 
  Both EPT and partner HIVST were acceptable despite noted barriers among Kenyan AGYW with etiologic diagnosis of CT/GC and their partners.
 Both EPT and partner HIVST were acceptable despite noted barriers among Kenyan AGYW with etiologic diagnosis of CT/GC and their partners.
  As public health personnel and resources are redirected to COVID-19, sexually transmitted diseases (STD) programs have been unable to sustain pre-COVID-19 activities.
 
  We used California (CA) surveillance data to describe trends in case reporting for gonorrhea (GC), chlamydia (CT), and syphilis of any stage in the pre- versus post- COVID-19 eras (January-June 2019 and January-June 2020). We also analyzed data from an electronic survey administered by the CA STD Control Branch to local health jurisdictions (LHJs) in April, June, and September of 2020 assessing the impact of COVID-19 on STD programs.
 
  There were sharp declines in cases of all reportable bacterial STDs occurring in conjunction with the March 19, 2020 CA stay-at-home order, most of which did not return to baseline by July. Comparing January-June 2020 to January-June of 2019, there were decreases in reported cases of CT (31%), late latent syphilis (19%), primary/secondary syphilis (15%), early non-primary non-secondary syphilis (14%), and GC (13%).