The pooled estimates did not exhibit any significant associations between SNPs rs3814055 and rs7643645 and the risk of ATDH (rs3814055 dominant model, OR = 1.00, 95% CI 0.82-1.22, P = 1.00; recessive model, OR = 1.17, 95% CI 0.76-1.78, P = .48; rs7643645 dominant model, OR = 1.04, 95% CI 0.64-1.68, P = .89; recessive model, OR = 0.98, 95% CI 0.65-1.49, P = .93). Subgroup analysis obtained similar negative results in Chinese patients, and the diagnostic criteria of ATDH may be the source of heterogeneity. Based on the meta-analysis described in this report, we did not observe any association between NR1I2 gene polymorphisms and ATDH susceptibility. However, this conclusion should be interpreted with caution due to the low number of studies and the relatively small sample size.Non-porous small molecule adsorbents such as [3,5-(CF3 )2 Pz]Cu3 (where Pz=pyrazolate) are an emerging class of materials that display attractive features for ethene-ethane separation. This work examines the chemistry of fluorinated copper(I) pyrazolates [3,5-(CF3 )2 Pz]Cu3 and [4-Br-3,5-(CF3 )2 Pz]Cu3 with much larger 1-butene in both solution and solid state, and reports the isolation of rare 1-butene complexes of copper(I), [3,5-(CF3 )2 Pz]Cu(H2 C=CHC2 H5 )2 and [4-Br-3,5-(CF3 )2 Pz]Cu(H2 C=CHC2 H5 )2 and their structural, spectroscopic, and computational data. The copper-butene adduct formation in solution involves olefin-induced structural transformation of trinuclear copper(I) pyrazolates to dinuclear mixed-ligand systems. Remarkably, larger 1-butene is able to penetrate the dense solid material and to coordinate with copper(I) ions at high molar occupancy. A comparison to analogous ethene and propene complexes of copper(I) is also provided.Leonurus japonicus Houtt., a traditional Chinese herbal medicine, is often used as a gynecological medicine with the effect of promoting blood circulation, regulating menstruation, clearing heat, and detoxificating. As the most important alkaloid in L. japonicus, leonurine has a wide range of biological activities, such as antioxidation, anti-inflammation, and anti-apoptosis. Cardiovascular system and central nervous system diseases are arrogant killers that threaten human lives and health around the world, but many drugs for treating them have certain side effects. This paper reviews the potential therapeutic effects of leonurine on cardiovascular system and central nervous system diseases, summarizes the previous research progress, and focuses on its therapeutic effect in various diseases. Although leonurine plays a prominent role in the treatment of cardiovascular system and central nervous system diseases, there are still some shortages, such as low bioavailability, weak transmembrane ability, and poor fat solubility. Therefore, the structure modification of leonurine may solve these problems and provide reference value for the development of new drugs. At present, leonurine is in clinical trial, and it is hoped that our summary will help to provide guidance for its future research on the basic science and clinical application.Most Bi-based semiconductors are incapable of photocatalytic reduction reaction from a thermodynamic view, owing to relatively positive conduction band potentials (ECB ).  https://www.selleckchem.com/products/necrosulfonamide.html  Here, a novel Bi-based metal-organic framework (Bi-MBA, MBA=4-mercaptobenzoic acid) with excellent photocatalytic reduction activities is developed. The ECB of Bi-MBA locates at -1.38 eV, which is able to efficiently reduce O2 , CrVI and CO2 . Theoretical calculations reveal the significant contribution of organic ligand (MBA) to the conduction band. Our results provide an effective route to improve the photocatalytic reduction activities of Bi-based photocatalysts.Success of nutrition-sensitive agriculture programmes targeted to women may be influenced by increased demands on women's and other household members' time and by time-related trade-offs to accommodate programme participation. However, evidence of how such programmes impact time use and whether changes in time-related demands negatively influence maternal or child health and nutrition outcomes is limited. This paper examines the impact of Helen Keller International's Enhanced Homestead Food Production programme in Burkina Faso (2010-2012) on women's and men's time use and associations between changes in women's time use and maternal and child health and nutrition outcomes. We used quantitative data from a cluster-randomized controlled trial (baseline 2010, endline 2012) and qualitative data from two rounds of process evaluation (2011, 2012). Two-stage analyses were used to first assess programme impacts on women's and men's time use using difference-in-difference impact estimates and second to evaluate whether programme impacts on women's time use were associated with changes in women's and children's health and nutrition outcomes. Programme impacts were considered significant if corrected P less then 0.01, and associations were considered significant if p less then 0.05 and p less then 0.01. Qualitative data were analysed through manual coding and by calculating the means and standard deviations for the time spent by women and men on activities in intervention and control groups. Findings show that the programme significantly increased the amount of time women spent on agriculture in the intervention compared to the control group, but this was not associated with changes in maternal or child health or nutrition outcomes. Process evaluation data supported these findings.
  This study aims to quantitatively summary the characteristics of synchronous multiple primary lung cancer (sMPLC), postoperative mortality, long-term prognosis, and prognostic effects of potential clinical parameters in patients with sMPLC after surgery.
 
  PubMed and Embase databases were systematically searched to identify studies that explored the prognosis of patients with sMPLC after surgery.
 
  Fifty-two studies with 3486 participants were included, and clinical characteristics were quantitatively summarized. The pooled proportion of sMPLC in lung cancer was 2.0% (95%CI, 1.6%-2.5%) with an increasing trend over time, and postoperative mortality was 1.4% (95%CI, 0.5%-2.7%) with a decreasing trend over time. The 5-year survival rate was 44.9% (95%CI, 37.4%-52.6%) and all long-term survival rates showed increasing trends over time. Poor long-term prognosis was observed in both limited resection (HR=1.357, 95%CI, 1.047-1.759, p=0.0210) and pneumonectomy (HR=2.643, 95%CI, 1.539-4.541, p=0.0004) by comparison of anatomical resection.