https://www.selleckchem.com/products/erastin.html Progressive loading of the lower limb muscles during running on a positive pressure or reduced gravity (Alter-G™) treadmill is suggested as a rehabilitation strategy after muscle and tendon injury but the influence of running up or downhill and at higher speeds is not known, nor are the interaction effects of speed, inclination, and indicated bodyweight. What are the lower limb EMG activation levels and cadence when running up and downhill in normal and reduced gravity? 10 recreationally active male athletes ran on a positive-pressure Alter-G™ treadmill at 3 indicated bodyweights (60 %, 80 %, and 100 %); 5 speeds (12, 15, 18, 21, and 24 km/h); for incline, decline, and flat conditions (-15 %, -10 %, -5%, 0%, 5%, 10 %, and 15 %); while monitoring the surface EMG of 11 leg muscles as well as cadence (strides per minute). Linear mixed models showed significant effect of running speed, inclination, and indicated bodyweight, with interaction effects observed. Increasing running speed was associated with thsEMG activity occurred in the flat and uphill conditions. Subject responses were quite variable for sEMG, less so for cadence. For the conditions examined, increasing running speed induced the largest changes in EMG of all muscles examined with smaller changes seen for manipulations of inclination and bodyweight. Evidence suggests that neuromuscular alterations in patients with an anterior cruciate ligament reconstruction (ACLR) are rooted in neurocognitive and proprioceptive deficits. The aim of this study was to assess neuromuscular control of athletes with ACLR under increased cognitive and environmental challenges. Do athletes with ACLR show a different neuromuscular response to cognitive and environmental challenges relative to controls? Cross-sectional study. Twenty athletes who had an ACLR (age 23.7 ± 4.3 years, 14 males, time post-surgery 258.6 ± 54 days) and twenty uninjured controls (age 21.4 ± 1.5 years, 14 ma