Traditional laparoscopic No.12a lymph node dissection in radical gastrectomy for gastric cancer may damage the peripheral blood vessels, and is not conducive to the full exposure of the portal vein and the root ligation of the left gastric vein. We recommend a new surgical procedure, the portal vein approach, to avoid these problems.
 
  25 patients with advanced gastric cancer underwent radical laparoscopic gastrectomy and No.12a lymph node were dissected by portal vein approach, including 7 cases with total gastrectomy, 18 cases with distal gastric resection, 14 males and 11 females. Operative time, intraoperative blood loss, time to first flatus, postoperative hospital stay, number of total lymph node dissection and No.12a lymph node dissection, No.12a lymph node metastasis rate and postoperative complications were statistically observed.
 
  All the patients were operated successfully and No.12a lymph node were cleaned by portal vein approach. A total of 683 lymph nodes were dissected, with the average numb gastric cancer is safe, feasible and has certain clinical application value.Since the emergence of novel Coronavirus (SARS-CoV-2) infection in Wuhan, China in December 2019, it has now spread to over 205 countries. The ever-growing list of globally spread corona virus-19 disease (COVID-19) patients has demonstrated the high transmission rate among the human population. Currently, there are no FDA approved drugs or vaccines to prevent and treat the infection of the SARS-CoV-2. Considering the current state of affairs, there is an urgent unmet medical need to identify novel and effective approaches for the prevention and treatment of COVID-19 by re-evaluating the knowledge of traditional medicines and repurposing of drugs. Here, we used molecular docking and molecular dynamics simulation approach to explore the beneficial roles of phytochemicals and active pharmacological agents present in the Indian herbs which are widely used in the preparation of Ayurvedic medicines in the form of Kadha to control various respiratory disorders such as cough, cold and flu. Our study has identified an array of phytochemicals present in these herbs which have significant docking scores and potential to inhibit different stages of SARS-CoV-2 infection as well as other Coronavirus target proteins. The phytochemicals present in these herbs possess significant anti-inflammatory property. Apart from this, based on their pharmaceutical characteristics, we have also performed in-silico drug-likeness and predicted pharmacokinetics of the selected phytochemicals found in the Kadha. Overall our study provides scientific justification in terms of binding of active ingredients present in different plants used in Kadha preparation with viral proteins and target proteins for prevention and treatment of the COVID-19. Communicated by Ramaswamy H. Sarma.Instantaneous blood coagulation after bioengineered liver transplantation is a major issue, and the key process in its prevention is the construction of the endothelial vascular bed on biomimetic scaffolds. However, the specific molecules involved in the regulation of the vascular bed formation remain unclear. Syndecan-4 is a type I transmembrane glycoprotein commonly expressed in the human body; its receptor has been reported as critical for optimal cell adhesion and initiation of intracellular signaling, indicating its promising application in vascular bed formation. In the current study, bioinformatics analysis and in vitro experiments were performed to evaluate whether syndecan-4 promoted endothelial cell migration and functional activation. Exogenous syndecan-4-overexpressing endothelial cells were perfused into the decellularized liver scaffold, which was assessed by Masson's trichrome staining. Western blotting and qRT-PCR were used to evaluate the effects of syndecan-4 on the thrombospondin 1 (THBS1) stability. We found that syndecan-4 promoted the adhesion of vascular endothelial cells and facilitated cell migration and angiogenesis. Furthermore, syndecan-4 overexpression resulted in a well-aligned endothelium on the decellularized liver scaffolds. Mechanistically, syndecan-4 destabilized THBS1 at the protein level. Therefore, our data revealed that syndecan-4 promoted the biological activity of endothelial cells on the bionic liver vascular bed through THBS1. These findings provide scientific evidences for solving transient blood coagulation after bionic liver transplantation.
  Globally, more women are likely to be obese than men, and the need for a gender-specific strategy concerning related health issues is important. Our study aimed to clarify gender difference related to obesity in Papua New Guinea by a sub-analysis of our previous questionnaire-based cross-sectional study. We used demographic and anthropometric data (body mass index) from a convenient sample of 558 community-dwelling healthy people (mean age 34.8 14.0 years, 48.2% women).  https://www.selleckchem.com/products/oxiglutatione.html  To clarify gender differences, we conducted an unpaired t-test and Chi-square test between males and females. Obesity was twice as common in females than males (20.5% vs. 10.4%) and over half of the women had abnormal body mass index (51.3% vs. 39.1%) compared to their male counterparts.
 Globally, more women are likely to be obese than men, and the need for a gender-specific strategy concerning related health issues is important. Our study aimed to clarify gender difference related to obesity in Papua New Guinea by a sub-analysis of our previous questionnaire-based cross-sectional study. We used demographic and anthropometric data (body mass index) from a convenient sample of 558 community-dwelling healthy people (mean age 34.8 14.0 years, 48.2% women). To clarify gender differences, we conducted an unpaired t-test and Chi-square test between males and females. Obesity was twice as common in females than males (20.5% vs. 10.4%) and over half of the women had abnormal body mass index (51.3% vs. 39.1%) compared to their male counterparts.It is effective to adsorb phosphate and ammonium from water by sludge-based biochar, while the desorption performance has not been studied systematically. Biochar in this study was prepared through the co-pyrolysis of sludge and walnut shells to remove NH 4 + and PO 4 3 - from water. The desorption characteristics of NH 4 + and PO 4 3 - from the post-adsorption sludge-based biochar were investigated. The effects of the adsorption condition (concentration of adsorption solution) and desorption conditions (pH value of desorption solution and desorption temperature and time) on desorption performance were examined. Several techniques were performed to characterise the properties of the post-adsorption sludge-based biochar. The adsorption amount of the pure sewage sludge biochar (SBC) for PO 4 3 - and the biochar derived from the co-pyrolysis of sewage sludge and walnut shell with the mixing ratio of 31 (MBC3-1) for NH 4 + were 14.19/ 23.75 mg/g and 9.28/ 16.23 mg/g, respectively, when the concentrations of the adsorbates were 100 and 500 mg/L.