https://www.selleckchem.com/products/PD-173074.html 58.4% (range, 52.6-62.3%)) values were significantly lower in the HM group (p < 0.005). The inside disc vessel density (iVD) was similar in both groups (62 ± 3.3% vs. 61.4 ± 2.7%) (p = 0.511). The vessel densities (VDs) of SCP and DCP, wpVD, and ppVD were lower in the non-pathological HM group, but the iVD value was similar in both groups. This suggests that the main cause of VD reduction is more likely related to globe elongation rather than reduced oxygen and nutrients due to the thinning of the posterior pole (retina, sclera, and choroid). CLINICALTRIALS. NCT04631991, 11/11/2020. NCT04631991, 11/11/2020. To evaluate corneal hysteresis (CH), acquired with ocular response analyzer (ORA), as a risk factor for glaucoma progression in early-stage primary open-angle glaucoma (POAG). In a historical cohort study, patients diagnosed in 2011 with early-stage POAG according to the Hodapp, Parrish and Anderson classification modified for Octopus perimetry and followed up until glaucomatous progression development; otherwise, observations were censored in October 2018. Cox regression was used to obtain hazard ratios (HR) to evaluate baseline variables (CH, central corneal thickness, gender, age IOP and glaucoma family history) as risk factors for perimetric glaucoma progression. A likelihood ratio test for interaction was performed in order to assess the effect of the combination of CH and CCT on the risk of progression. Of the cohort of 1573 patients, 11.38% developed early-stage POAG progression during the follow-up. The mean follow-up time was 3.28 ± 1.92years. Patients without progression had a higher CH (11.35 ± 1.43 vs 9.07 ± 1.69mmHg; p < 0.001) and CCT (570.75 ± 17.71 vs 554.51 ± 23.20; p < 0.001). In the multivariate analysis, each 1mmHg of lower CH was associated with an increase of 2.13 times in the HR of progression (95% CI 1.92-2.32; p < 0.001). CH hazard ratio was modified by CCT, with higher values of CCT and