To the authors' knowledge, the proposed method is the first to integrate EM tracking and laparoscopic image processing for generation of training labels. They demonstrate that their framework achieves accurate, automatic tool segmentation (i.e. without any manual labelling of the surgical tool to be tracked) and robust tool tracking in laparoscopic image sequences.Knee arthritis is a common joint disease that usually requires a total knee arthroplasty. There are multiple surgical variables that have a direct impact on the correct positioning of the implants, and an optimal combination of all these variables is the most challenging aspect of the procedure. Usually, preoperative planning using a computed tomography scan or magnetic resonance imaging helps the surgeon in deciding the most suitable resections to be made. This work is a proof of concept for a navigation system that supports the surgeon in following a preoperative plan. Existing solutions require costly sensors and special markers, fixed to the bones using additional incisions, which can interfere with the normal surgical flow. In contrast, the authors propose a computer-aided system that uses consumer RGB and depth cameras and do not require additional markers or tools to be tracked. They combine a deep learning approach for segmenting the bone surface with a recent registration algorithm for computing the pose of the navigation sensor with respect to the preoperative 3D model. Experimental validation using ex-vivo data shows that the method enables contactless pose estimation of the navigation sensor with the preoperative model, providing valuable information for guiding the surgeon during the medical procedure.Virtual reality (VR) has the potential to aid in the understanding of complex volumetric medical images, by providing an immersive and intuitive experience accessible to both experts and non-imaging specialists. A key feature of any clinical image analysis tool is measurement of clinically relevant anatomical structures. However, this feature has been largely neglected in VR applications. The authors propose a Unity-based system to carry out linear measurements on three-dimensional (3D), purposefully designed for the measurement of 3D echocardiographic images. The proposed system is compared to commercially available, widely used image analysis packages that feature both 2D (multi-planar reconstruction) and 3D (volume rendering) measurement tools. The results indicate that the proposed system provides statistically equivalent measurements compared to the reference 2D system, while being more accurate than the commercial 3D system.A realistic image generation method for visualisation in endoscopic simulation systems is proposed in this study. Endoscopic diagnosis and treatment are performed in many hospitals. To reduce complications related to endoscope insertions, endoscopic simulation systems are used for training or rehearsal of endoscope insertions. However, current simulation systems generate non-realistic virtual endoscopic images. To improve the value of the simulation systems, improvement of the reality of their generated images is necessary. The authors propose a realistic image generation method for endoscopic simulation systems. Virtual endoscopic images are generated by using a volume rendering method from a CT volume of a patient. They improve the reality of the virtual endoscopic images using a virtual-to-real image-domain translation technique. The image-domain translator is implemented as a fully convolutional network (FCN). They train the FCN by minimising a cycle consistency loss function. The FCN is trained using unpaired virtual and real endoscopic images. To obtain high-quality image-domain translation results, they perform an image cleansing to the real endoscopic image set. They tested to use the shallow U-Net, U-Net, deep U-Net, and U-Net having residual units as the image-domain translator. The deep U-Net and U-Net having residual units generated quite realistic images.The overall prevalence of chronic kidney disease in the general population is ∼14% with more than 661,000 Americans having a kidney failure. Ultrasound (US)-guided renal biopsy is a critically important tool in the evaluation and management of renal pathologies.  https://www.selleckchem.com/products/buloxibutid.html  This Letter presents KBVTrainer, a virtual simulator that the authors developed to train clinicians to improve procedural skill competence in US-guided renal biopsy. The simulator was built using low-cost hardware components and open source software libraries. They conducted a face validation study with five experts who were either adult/pediatric nephrologists or interventional/diagnostic radiologists. The trainer was rated very highly (>4.4) for the usefulness of the real US images (highest at 4.8), potential usefulness of the trainer in training for needle visualization, tracking, steadiness and hand-eye coordination, and overall promise of the trainer to be useful for training US-guided needle biopsies. The lowest score of 2.4 was received for the look and feel of the US probe and needle compared to clinical practice. The force feedback received a moderate score of 3.0. The clinical experts provided abundant verbal and written subjective feedback and were highly enthusiastic about using the trainer as a valuable tool for future trainees.The authors present a deep learning algorithm for the automatic centroid localisation of out-of-plane US needle reflections to produce a semi-automatic ultrasound (US) probe calibration algorithm. A convolutional neural network was trained on a dataset of 3825 images at a 6 cm imaging depth to predict the position of the centroid of a needle reflection. Applying the automatic centroid localisation algorithm to a test set of 614 annotated images produced a root mean squared error of 0.62 and 0.74 mm (6.08 and 7.62 pixels) in the axial and lateral directions, respectively. The mean absolute errors associated with the test set were 0.50 ± 0.40 mm and 0.51 ± 0.54 mm (4.9 ± 3.96 pixels and 5.24 ± 5.52 pixels) for the axial and lateral directions, respectively. The trained model was able to produce visually validated US probe calibrations at imaging depths on the range of 4-8 cm, despite being solely trained at 6 cm. This work has automated the pixel localisation required for the guided-US calibration algorithm producing a semi-automatic implementation available open-source through 3D Slicer.