https://www.selleckchem.com/products/endoxifen-hcl.html Quantification of the relative abundance of each protein revealed that alpha and beta fibrinogenase and PLA2, which constituted 18-26% of the total proteome, were the most abundant. The 3 uncommon proteins have no known function in snake venom. However, actiflagelin activates sperm motility; cystatin inhibits angiogenesis, while cathelicidin exerts antimicrobial effects. The three Nigerian Naja genus proteomes displayed 70% similarity in composition, which suggests the possibility of formulating antivenom that may cross-neutralise the venoms of cobra species found in Nigeria. These data provide insights into clinically relevant peptides/proteins present in the venoms of these snakes. Data are available via ProteomeXchange with identifier PXD024627. To evaluate the associations between homocysteine (Hcy) and cardiovascular health in South African adolescents. Circulating Hcy concentrations of 172 South African adolescents (105 girls, ages 13 to <18years) were measured. Anthropometric and cardiovascular factors were also included and cross-sectionally analyzed through general linear models. Hcy correlated positively with body weight (P=.03; after adjusting for multiple testing, it was not regarded as significant) and muscle mass (P=.01), but negatively with fibrinogen concentrations (P=.001). Across Hcy tertiles, blood pressure produced approximating U-shaped curves, with differences between the middle and upper tertiles (all P<.02). Forty percent of the adolescents had elevated blood pressure, of whom 37% fell in the lowest and 38% in the highest Hcy tertiles. Hcy differed between the sexes (with boys having higher Hcy), but not between subgroups based on puberty, weight, stunting, smoking, or alcohol consumption. Both high and low Hcy could be early contributing risk factors to cardiovascular health. The associations between Hcy and blood pressure suggest that dietary and lifestyle manipulation, to achieve the