https://www.selleckchem.com/btk.html Given the very frequent prescription of non-opiod analgesics (NOA), their dependence potential has been a subject of research. Increased use of NOA in the last decade has led authors to publish case reports to describe the dependence potential of these agents. Metamizole (dipyrone) has become one of the most popular NOA agents, in being easily accessible and inexpensive. Its analgesic effect depends on the central inhibition of cyclo-oxigenase (COX-3) and activation of the opiodergic and cannabinoid systems. Recent research has also stressed its possible anxiolytic effects. Our Literature search indicated no previous reports regarding metamizole misuse. Case of a 41 year old female patient is presented. She had self administered increasing doses of i.v. metamizole reaching up to 10 ampules per day. Considering the risk of mortality due to the metamizole's side effect of agranulocytosis, we thought that it could be a significant contribution to the literature to present a case of a possible metamizole abuse.Self-injurious behaviors (SIBs) in autism spectrum disorder (ASD) are destructive symptoms that can lead to dangerous injuries and life-threatening risks. Agitation and SIBs may not respond to psychopharmacological and behavioral interventions. There are reports in the literature on improvement after electroconvulsive therapy (ECT) in cases not responding pharmacotherapy. However, data on the efficacy of the therapy on the benefiting patients, the course of the treatment and on the use of maintenance ECT (m-ECT) are very limited. This report presents the clinical features and the course of m-ECT on two cases under follow up for pharmacotherapy resistant ASD with significant agitation, mood disorder and SIBs that could cause severe head traumas. The initial stage of therapy consisted of 7 sessions of ECT patients showed improvement after the 5th session. m-ECT were started since the agitation repeated one week after discharge de