The purpose of this study was to describe the reflections of adults with visual impairments about learning to run during K-12 physical education. An interpretative phenomenological analysis research approach was used, and eight adults (age 22-35 years) with visual impairments served as participants. Primary data sources were semistructured, audiotaped telephone interviews and reflective interview notes. Based on a thematic data analysis process, two themes were developed (a) "I wouldn't expect anything better from you" running instruction in physical education and (b) "You look like the guy in the crosswalk signal" making up for the shortcomings of physical education. The narratives portraying these themes highlight the lack of instruction that took place in physical education, and the fact that no running instruction occurred at all. These findings indicate that professionals working with individuals with visual impairments should use instructional strategies that will allow for maximum access to learning fundamental movement skills such as running.Videoconferencing is a novel method for overcoming time and transportation barriers to leisure-time physical activity (LTPA) interventions. This study examined the feasibility of a group videoconference intervention on LTPA self-regulatory skills training in a sample of nine adults with spinal cord injury (SCI). Session implementation checklists and self-report surveys were administered during four weekly sessions to assess intervention management, group processes, intervention resources, and initial efficacy. Attendance rate was high (91.7%), and the average weekly session duration was 79.6 min. Participants reported high ratings of group cohesion, facilitator collaboration, session content comprehension, and ease in operating the videoconference platform. Knowledge sharing among the group ranged from 18 to 58 exchanges per session, demonstrating learning and group cohesion. LTPA frequency increased among 44% of participants, and 22% of participants achieved the SCI-specific aerobic guidelines. Overall, group videoconferencing holds promise for LTPA support among adults with SCI. Long-term research is warranted to test LTPA self-regulatory and behavioral effects.Objective To identify small non-coding RNA (sncRNA) serum biomarkers that predict response to triple disease-modifying antirheumatic drug (DMARD) therapy in patients with early rheumatoid arthritis (RA). Methods Early RA patients entered into a treat-to-target management algorithm, with triple DMARD therapy (methotrexate + sulphasalazine + hydroxychloroquine). Patients were assessed following 6 months of therapy and classified as EULAR responders or non-responders. RNA was isolated from 42 archived serum samples, collected prior to commencement of triple DMARD therapy. Small RNA sequencing was performed and the reads mapped to annotations in a database of small human non-coding RNAs. Differential expression analysis was performed, comparing responders (n=24) and non-responders (n=18). Results Pre-treatment levels of 4 sncRNAs were significantly increased in non-responders chr1.tRNA131-GlyCCC (4.1-fold, adj.P-value 0.01); chr2.tRNA13-AlaCGC (2.2-fold, adj.Pvalue 0.02); U2-L166 (6.6-fold, adj.P-value 0.02); and piR-35982 (2.4-fold; adj.P-value 0.03). 5S-L612 was the only sncRNA significantly increased in responders (3.3-fold; adj.Pvalue 0.01). Reads for chr1.tRNA131-GlyCCC and chr2.tRNA13-AlaCGC mapped to the 5' end of each tRNA gene and were truncated at the anti-codon loop, consistent with these sncRNAs having roles as 5' translation interfering tRNA halves (tiRNAs). Conclusion Pre-treatment levels of specific serum sncRNAs might facilitate identification of patients more likely to respond to triple DMARD therapy.Objective We assessed if the inverse OARSI-OMERACT criteria relate to concurrent radiographic knee osteoarthritis (KOA) progression and decline in walking speed as well as future knee replacement. Methods We conducted knee-based analyses of data from the Osteoarthritis Initiative. All knees had symptomatic osteoarthritis at least doubtful radiographic KOA (Kellgren-Lawrence Grade≥1) and knee pain≥10/100 (WOMAC pain) at the 12-month visit. The inverse of the OARSI-OMERACT responder criteria depended on knee pain and function, and global assessment of knee impact. We used generalized linear mixed models to assess the relationship of the inverse OARSI-OMERACT criteria over 2 years (i.e.,12 and 36-month visits) with worsening radiographic severity (any increase in Kellgren-Lawrence Grade from 12- to 36-months) and decline in self-selected 20-m walking speed of >0.1m/s (from 12- to 36-months).  https://www.selleckchem.com/products/ldn193189.html  We used a Cox model to assess time to knee replacement during the 6 years after the 36-month visit as an outcome. Results Among the 1,746 analyzed, 19% met the inverse OARSI-OMERACT criteria. Meeting the inverse OARSI-OMERACT criteria was associated with almost double the odds of experiencing concurrent worsening in radiographic KOA severity (odds ratio [OR]=1.89 (95% confidence interval [CI]=1.32 to 2.70)) or decline in walking speed (OR=1.82 (95%CI=1.37 to 2.40)). A knee meeting the inverse OARSI-OMERACT criteria was more likely to receive a knee replacement after the 36-month visit (23%) compared with a non-responder (10%; hazard ratio=2.54, 95%CI=1.89 to 3.41). Conclusion The inverse OARSI-OMERACT criteria for worsening among people with KOA had good construct validity in relation to clinically relevant outcomes.The Canadian Inflammatory Myopathy Study (CIMS) is a multicenter prospective cohort recruiting in 8 centers across Canada. One of the aims of CIMS is to conduct and participate in clinical trials in autoimmune inflammatory myopathies (AIM). Conducting clinical trials in rare diseases such as AIM presents challenges. During this symposium, experts in the field presented different solutions to successfully conduct clinical trials in AIM, including the importance of collaboration and careful trial design, as well as training and mentoring of young investigators.Brain magnetic resonance imaging (MRI) findings in craniofacial morphea including en coup de sabre (ECDS) localized scleroderma and Parry-Romberg syndrome (PRS; progressive facial hemiatrophy) are not unusual1, but the relevance of rare abnormalities is unknown. We report 2 cases in which distant cerebellar lesions on brain MRI occurred with varying clinical neurologic manifestations.