Cementless fixation is an alternative to cemented unicompartmental knee replacement (UKR). The aim of this study was to determine if cementless UKR fixation is as good as cemented by comparing the five-year migration measured radiostereometric analysis (RSA) in a randomised controlled trial.
 
  Thirty-nine patients were randomised to receive either a cemented or a cementless Oxford UKR and were studied at intervals up to five years to assess migration with RSA and radiolucencies with radiographs.
 
  During the first year there was a small and significant amount of migration, predominantly in an anterior direction, of both the cemented (0.24mm, SD 0.32, p=0.01) and cementless (0.26mm, SD 0.31, p=0.00) femoral components. Thereafter there was no significant migration in any direction. At no stage was there any significant difference between the migrations of the cemented or cementless femoral components. During the first year, particularly the first three months, the cementless tibial components subsided 0.28mm (SD 0.19, p=0.00). This was significantly (p=0.00) greater than the subsidence of the cemented tibial component (0.09, SD 0.19, p=0.28).  https://www.selleckchem.com/products/zotatifin.html  Between the second and fifth years there was no significant migration of either cemented or cementless tibial components. At five years radiolucent lines occurred significantly less with cementless (one partial) compared to cemented (six partial and one complete) tibial components.
 
  As, between two and five years, there was no significant migration of cemented or cementless components, and no significant difference between them, we conclude that cementless fixation is as reliable as cemented. It may be better as there are fewer radiolucent lines.
 As, between two and five years, there was no significant migration of cemented or cementless components, and no significant difference between them, we conclude that cementless fixation is as reliable as cemented. It may be better as there are fewer radiolucent lines.
  Epilepsy is one of the main clinical problems in Angelman syndrome (AS). Seizures typically start in early childhood then decrease or are often alleviated by young adulthood. Several studies using AS model mice showed comparable seizure susceptibility during young adulthood. In contrast, the course of epilepsy post young adulthood differs from persistently relieved to rerising among reports. To elucidate this, we evaluated the seizure susceptibility of AS model mice of two different ages.
 
  Mice lacking maternal Ube3a gene (Ube3a
  ) of C57BL/6 background or their littermate wild type (WT) were divided into two groups by age, 2 to 3months (2-3M) and 6 to 12months (6-12M), corresponding to adolescent to young adult aged and middle aged humans, respectively. Seizure susceptibility was evaluated by flurothyl inhalation or intraperitoneal injection of pentylenetetrazole (PTZ IP)-induced acute seizure protocol.
 
  In the flurothyl-induced seizure paradigm, the latency to seizure occurrence had a significant interaction with genotype and age. Post-hoc analysis revealed that the latency was significantly shorter at 6-12M than at 2-3M in Ube3a
  mice, and in Ube3a
  mice than in WT mice at 6-12M. No significant interaction or difference was observed by PTZ IP.
 
  The flurothyl-induced seizure paradigm revealed that seizure susceptibility of Ube3a
  mice increased with age, similar to clinical studies reporting the reappearance of epilepsy in older age. The flurothyl-induced seizure paradigm applied to middle-aged Ube3a
  mice could be a suitable protocol for screening drugs against seizures in AS.
 The flurothyl-induced seizure paradigm revealed that seizure susceptibility of Ube3am-/p+ mice increased with age, similar to clinical studies reporting the reappearance of epilepsy in older age. The flurothyl-induced seizure paradigm applied to middle-aged Ube3am-/p+ mice could be a suitable protocol for screening drugs against seizures in AS.
  Reversible lesions in the splenium of the corpus callosum (SCC) with viral infections are associated mainly with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). We report a pediatric patient in thyroid crisis with reversible SCC lesions.
 
  We diagnosed a 9-year-old girl with thyroid crisis. She had presented with fever, tachycardia, and impaired consciousness. Magnetic resonance imaging revealed hyperintense signals in the splenium and genu of the corpus callosum and a white matter lesion of the left hemisphere in diffusion-weighted imaging. The initial, tentative diagnosis was clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). We initiated intravenous methylprednisolone pulse therapy; thereafter, her level of consciousness rapidly improved. On admission, thyroid function studies revealed elevation of free thyroxine and a low level of thyroid stimulating hormone with thyroid-related autoantibodies. She was begun on thiamazole and was discharged without neurological sequelae.
 
  Thyroid crisis is similar to acute encephalitis or encephalopathy associated with viral infection, especially with MERS, because the clinical and radiological features resemble those of thyroid crisis; therefore, thyroid diseases should be considered as a possible cause of reversible lesions in the splenium of the corpus callosum.
 Thyroid crisis is similar to acute encephalitis or encephalopathy associated with viral infection, especially with MERS, because the clinical and radiological features resemble those of thyroid crisis; therefore, thyroid diseases should be considered as a possible cause of reversible lesions in the splenium of the corpus callosum.This article presents a unified approach of controller design in cascade control structure (CCS) for unstable, integrating and stable processes with dead-time to achieve enhanced load disturbance rejection. The design of inner and outer loop controllers in CCS is based, partially on the direct synthesis approach and partially on the pole placement method. First, the parameters of the inner loop controller are obtained and then the outer loop controller is designed by considering the inner loop as a part of the primary plant. The proposed design approach deals with a wide range of processes having unstable, integrating and stable dynamics in a unified way. It is applied directly on the higher and lower order processes, as the proposed strategy is acquitted from the approximation of the dead-time and model order reduction of the plant. Simulations have been conducted to show the efficacy of the present approach. The results shows that the present approach provides enhanced regulatory performance as compared to the recently reported approaches from the literature.