BACKGROUND Choosing trial outcome measures is important. When outcomes are not clinically relevant or important to parents/patients, trial evidence is less likely to be implemented into practice. This study aimed to determine optimal outcome measures for a trial of no routine gastric residual volume (GRV) measurement in critically ill children. METHODS A mixed-methods approach was used a focused literature review, parent and clinician interviews, a modified 2-round Delphi, and a stakeholder consensus meeting. RESULTS The review generated 13 outcomes. Fourteen pediatric intensive care unit (PICU) parents proposed 3 additional outcomes; these 16 were then rated by 28 clinicians in Delphi round 1. Six further outcomes were proposed, and 22 outcomes were rated in the second round. No items were voted "consensus out." The 18 "no-consensus" items were voted in a face-to-face meeting by 30 participants. The final 12 outcome measures were time to reach energy targets, ventilator-associated pneumonia, vomiting, time enteral feeds withheld per 24 hours, necrotizing enterocolitis, length of invasive ventilation, PICU length of stay, mortality, change in weight and markers of feed intolerance (parenteral nutrition administered), feed formula altered, and change to postpyloric feeds all secondary to feed intolerance. CONCLUSION We have identified 12 outcomes for a trial of no GRV measurement through a multistage process, seeking views of parents and clinicians. © 2020 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals, Inc. on behalf of American Society for Parenteral and Enteral Nutrition.Polylactic acid (PLA) dissolved (15 wt.%) in ethyl acetate (EtAc) dimethyl sulfoxide (DMSO) binary systems (01; 13, and 23 v/v) was used as carrier to obtain carvacrol (CA)-loaded (20 wt.% with respect to PLA) matrices by electrospinning, in comparison with solvent casting. Field emission scanning electron microscopy (FESEM) observations showed that CA-loaded electrospun fibers were thinner than the CA-free ones, and their encapsulating efficiency (EE) increased when EtAc was present in the solvent. The cast films had higher EE (up to 89%) than the electrospun mats (maximum 68%). Thermogravimetric analysis and differential scanning calorimetry revealed that CA-free matrices retain more solvent than the samples with CA; this effect is being more noticeable in fibers rather than in cast films. The thermal analysis revealed stronger retention forces of CA in the fibers than in the cast material and the CA plasticizing effect in the PLA matrices, in accordance with its retained amount. PRACTICAL APPLICATION The carvacrol-loaded polylactic acid materials obtained in this study are intended to serve as possible active layer in obtaining active (antimicrobial and/or antioxidant) multilayer materials for the packaging of foodstuffs, when applied onto a supporting polymer layer. Active properties of the material, as well as the potential carvacrol sensory impact, in packaged products should be assessed in further studies. © 2020 Institute of Food Technologists®.BACKGROUND Our objective was to examine occupational risk factors for musculoskeletal disorders of the neck, back, and knee among railroad maintenance-of-way (MOW) workers. METHODS Four thousand eight-hundred sixteen active, retired, and disabled members of the Brotherhood of Maintenance of Way Employes Division (BMWED) completed a survey. We computed adjusted prevalence ratios (aPRs) using Poisson regression for neck, back, and knee musculoskeletal symptoms by work exposures, adjusted for age, region, race/ethnicity, smoking, and potential second job and spare time vehicle vibration exposure. RESULTS Among active male BMWED members, we found associations between use of high-vibration vehicles and neck pain (aPR = 1.47, 95% confidence interval (CI) 1.07-2.03) and knee pain (aPR = 1.38, 95% CI 1.04-1.82) for more than 1.9 years (vs 0) of full-time equivalent use; but not back pain. Back pain radiating below the knee (sciatica indicator) was associated with high-vibration vehicle use greater than 0.4 and less than 1.9 years (aPR = 1.58, 95% CI 1.15-2.18). We also found significant associations between often or always lifting, pushing, pulling, or bending on the job (vs seldom or never) and neck pain (aPR = 2.43, 95% CI 1.20-4.90), back pain (aPR = 1.94, 95% CI 1.24-3.03), the sciatica indicator (aPR = 5.18, 95% CI 1.28-20.95), and knee pain (aPR = 2.84, 95% CI 1.47-5.51), along with positive gradients in the outcome by exposure time. CONCLUSIONS Biomechanical work exposures, including force and nonneutral postures, were associated with neck, lower back, and knee pain. Whole-body vibration, as measured by the duration of use of high-vibration vehicles, was associated with neck pain, knee pain, and sciatica. Prevention programs should address occupational risk factors for musculoskeletal disorders among MOW workers. © 2020 Wiley Periodicals, Inc.Antiheroes are characters that share features with both heroes and villains, typified as selfish and rule breakers, but who end up doing something good for society. In this research, we examined how priming people with antiheroes (vs. heroes) affected their sensation seeking. We reason that antiheroes (vs. heroes) are more associated with temporally close (vs. past and future) events. Given that sensation seeking is related to being focused on the present (vs. past or future), we hypothesized that if people are primed with antiheroes (vs. heroes) they are more likely to seek sensation. Findings from a series of five experimental studies provide insights into the effect of priming with an antihero on people's sensation seeking, providing directions for future research in psychology and practical applications in the areas of marketing strategy and consumer behaviour. © 2020 The British Psychological Society.Magnesium may be used as an adjunctive analgesic for perioperative pain management because of its antinociceptive properties. This study investigated the analgesic efficacy of intraperitoneal ropivacaine combined with magnesium sulfate in canine ovariohysterectomy. Forty-five dogs sedated with acepromazine/meperidine and anesthetized with propofol/isoflurane were randomly distributed into three treatments, administered intraperitoneally (n = 15 per group) saline solution (group S), 0.25% ropivacaine (3 mg/kg) alone (group R), or in combination with magnesium sulfate (20 mg/kg, group R-Mg). Intravenous fentanyl was given to control cardiovascular responses to surgical stimulation. Postoperative pain was assessed using an Interactive Visual Analog Scale (IVAS), the short form of the Glasgow Composite Pain Scale, and mechanical nociceptive thresholds.  https://www.selleckchem.com/products/pixantrone-maleate.html  Morphine/meloxicam was administered as rescue analgesia. Intraoperatively, the R-Mg group required less fentanyl (p = .02) and exhibited higher incidence of hypotension (systolic arterial pressure less then 90 mm Hg, p = .