Construct and evaluate the care cascade for pulmonary tuberculosis in the indigenous population of the department of Cauca (Colombia) and identify existing gaps. Mixed-methods sequential explanatory design. In the first phase, the pulmonary tuberculosis care cascade for the indigenous population of Cauca was evaluated. Data were obtained from secondary sources and all cases diagnosed from 1 January 2016 to 31 December 2017 were included. In the second phase, semi-structured interviews were done with nine program coordinators and 11 nursing auxiliaries to explain identified gaps. Absolute and percentage values were estimated for each of the steps and gaps in the care cascade. Quantitative and qualitative results were triangulated. In 2016 and 2017, an estimated 202 patients with respiratory symptoms were expected to be positive and 106 cases of pulmonary tuberculosis were reported among the indigenous population of the department of Cauca. A gap of 47.5% was found for diagnosis, since only 52.5% of subjects were diagnosed in health services. This gap was explained by poor quality of samples and flawed smear techniques; flaws in correct identification of patients with respiratory symptoms; limited access to diagnostic methods, such as culture and molecular tests; and limited training and high turnover of personnel in health service provider institutions. The tuberculosis control program should focus actions on bridging the gap in case detection in the indigenous population. The tuberculosis control program should focus actions on bridging the gap in case detection in the indigenous population.The present report describes the process and results obtained with a knowledge translation project developed in three stages to identify barriers to the National Childbirth Guidelines in Brazil as well strategies for effective implementation. https://www.selleckchem.com/products/Nolvadex.html The Improving Programme Implementation through Embedded Research (iPIER) model and the Supporting Policy Relevant Reviews and Trials (SUPPORT) tools provided the methodological framework for the project. In the first stage, the quality of the Guidelines was evaluated and the barriers preventing implementation of the recommendations were identified through review of the global evidence and analysis of contributions obtained in a public consultation process. In the second stage, an evidence synthesis was used as basis for a deliberative dialogue aimed at prioritizing the barriers identified. Finally, a second evidence synthesis was presented in a new deliberative dialogue to discuss six options to address the prioritized barriers 1) promote the use of multifaceted interventions; 2) promote educational interventions for the adoption of guidelines; 3) perform audits and provide feedback to adjust professional practice; 4) use reminders to mediate the interaction between workers and service users; 5) enable patient-mediated interventions; and 6) engage opinion leaders to promote the use of guidelines. The processes and results associated with each stage were documented and formulated to inform a review and update of the Guidelines and the development of an implementation plan for the recommendations. An effective implementation of the Guidelines is relevant to improve the care provided during labor and childbirth in Brazil. To determine the probabilities of transition between different types of care and diagnostic states for the population infected with COVID-19 in Colombia, by age group. Using the official reports of COVID-19 cases in Colombia, transition matrices were calculated for the states according to the location of an infected person during the evolution of the disease, i.e. home, hospital or intensive care unit (ICU). The probabilities that infected persons will move to a state of "recovery" or "death" within a 24-hour period were also calculated for different territories. The population aged 66 or older had a higher probability of moving to the state of "death" in a period of 24 hours; this finding was confirmed for all the territories analyzed, with a probability between 52% and 57%, except for the Aburrá Valley where the probability was 25%. In Colombia, out of every 200 infected persons treated at home, one will require admission to the ICU within 24 hours. If the infected person is older than 65, one of every 53 cases will require admission to the ICU. Of infected hospital patients, one in 10 will require ICU admission within 24 hours. The results provide information about the pressure that the increase of people infected by COVID-19 exerts on hospital capacity. Some people die without ever having been in an intensive care bed. The results of the transition probabilities show low case fatality rates for those under 65. The results provide information about the pressure that the increase of people infected by COVID-19 exerts on hospital capacity. Some people die without ever having been in an intensive care bed. The results of the transition probabilities show low case fatality rates for those under 65.[This corrects the article DOI 10.18632/oncotarget.3181.]. The global COVID-19 pandemic caused great impacts and influences to human psychology. As a result, youths who are kept at home for a long time easily develop irritability and problematic behaviors. However, relatively little attention has been paid to the relations among irritability, coping style, and subjective well-being of the youth. Overall, 1,033 youth respondents (aged 18-30 yr) from seven provinces in China were investigated in 2020 using the irritability, depression, and anxiety scale, coping style scale, and well-being index scale. Among the dimensions of irritability of the youth, anxiety received the highest score, followed by introversion irritability, extroversion irritability, and depression. Irritability had significant regional differences. The total score of irritability among rural youth was significantly higher than that of urban youth ( 0.05). The irritability level of youths with parents' emotional status was harmonious and good relations with family members and peers was far lower than those of youths who have poor relations between parents, family members, and peers ( 0.05). The irritability level of youths with a lower monthly household income was higher ( 0.05). Irritability of the youth had significantly negative correlations with positive response and SWB, and it had a significantly positive correlative with negative response. Coping style can mediate the relationship between irritability and SWB of the youth to some extent. Significant correlations exist among irritability, coping style, and SWB of the youth. Irritability can be used to predict SWB indirectly through positive response. Significant correlations exist among irritability, coping style, and SWB of the youth. Irritability can be used to predict SWB indirectly through positive response.