https://www.selleckchem.com/products/Idarubicin.html We have quantum chemically studied the reactivity, site-, and regioselectivity of the 1,3-dipolar cycloaddition reaction between methyl azide and various allenes, including the archetypal allene propadiene, heteroallenes, and cyclic allenes, using density functional theory (DFT). The 1,3-dipolar cycloaddition reactivity of linear (hetero)allenes decreases as the number of heteroatoms in the allene increases and the formation of the 1,5-adduct is, in all cases, favored over the 1,4-adduct, both effects find their origin from the strength of the primary orbital interactions . The cycloaddition reactivity of cyclic allenes was also investigated, and the increased predistortion of allenes, that results upon cyclization, leads to systematically lower activation barriers not due to the expected variations in the strain energy, but instead from the differences in the interaction energy . The geometrical predistortion of cyclic allenes enhances the reactivity compared to linear allenes through a unique mechanism that involves a smaller HOMO-LUMO gap, which manifests into more stabilizing orbital interactions . © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND The association between palatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) polymorphism and mortality is not well understood. We investigated the impact of PNPLA3 I148M (rs738409) polymorphism on overall and cardiovascular mortality based on the presence of NAFLD. METHODS The Third National Health and Nutrition Examination Survey (NHANES) from 1991 to 1994 and NHANES III-linked mortality data through 31 December 2015 were utilized in this study. RESULTS Of 4,814 participants, 50.7% were homozygous for the C-allele and 12.6% were homozygous for the G-allele. During a follow-up of 20 years, there were a total of 1,255 deaths, 422 attributed to cardiovascular disease. There was a significant association with overall mortality among those