31, 95% CI 1.51-6.77, P=0.005) and disease-free survival (DFS) (HR 2.73, 95% CI 1.34-5.47, P=0.007) in LARC patients. A low pretreatment AFR level was significantly associated with a poor 5-year OS and DFS by the Log rank test (P=0.003 and 0.006, respectively).
 
  Pretreatment AFR level was an independent prognostic factor in LARC patients undergoing TME after nCRT.
 Pretreatment AFR level was an independent prognostic factor in LARC patients undergoing TME after nCRT.
  The prognostic value of serum calcium levels in nasopharyngeal carcinoma (NPC) remains unknown. This study aimed to evaluate the prognostic value of serum calcium levels in patients with NPC.
 
  A total of 2094 patients diagnosed with NPC between April 2009 and September 2012 were enrolled in this retrospective analysis. The median follow-up time was 96.3 months (range 4.1-120.0 months). Univariate and multivariable Cox proportional hazards models were used to identify significant and independent prognostic predictors of overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and relapse-free survival (RFS).
 
  Overall, low serum calcium levels were detected in 1109/2094 (53.00%) patients and tended to be more frequently detected in older (
  <0.001) and female (
  =0.001) patients. Patients with low serum calcium levels had poorer OS (
  =0.011), DFS (
  =0.012) and DMFS (
  =0.004) than those with high serum calcium levels, but serum calcium levels had no significant effect on RFS (
  =0.376). In univariate and multivariable analyses, low serum calcium levels were a statistically significant and independent prognostic factor for OS, DFS, and DMFS but had no prognostic value for RFS.
 
  Serum calcium levels can serve as a prognostic predictor and guide more individualized treatment for NPC patients.
 Serum calcium levels can serve as a prognostic predictor and guide more individualized treatment for NPC patients.
  To compare running suture (RS) and interrupted suture (IS) of vesicourethral anastomosis (VUA) during open retropubic radical prostatectomy (RRP) on early urinary continence and extravasation.
 
  Single center analysis of 211 patients who underwent RRP performed by a single surgeon during 2008 to 2017 was retrospectively analyzed. For VUA, we used the standard interrupted suture technique (n=100) with a 3-0 PDS suture. The 
  (n=111) was performed with 12-bite suture using 3-0 PDS. The primary endpoints were extravasation and early continence.  https://www.selleckchem.com/products/elexacaftor.html  Demographic and peri-operative data were collected and analyzed using Pearson's chi-square, 
  -Test and Mann-Whitney 
  -test. A binary logistic regression analysis was carried out to explore predictors that affected early continence after catheter removal.
 
  The rates of early urinary incontinence (UI) were 7.7% vs 42.2% (p<0.001). The duration of catheterization and hospitalization was significantly shorter in the interrupted group (4 days vs 5 days, p<0.001 and 5 days vs 6 days, p<0.001). The groups did not differ significantly in body mass index or prostate volume. There were older patients and higher PSA levels in the group with 
  technique. No significant difference was found in the postoperative extravasation rates between both groups (13.5% vs 12%, p=0.742).
 
  Running vesicourethral anastomosis increased the rate of early urinary incontinence. Both anastomosis techniques provided a similar rate of postoperative urine extravasation. VUA should only be one of the many criteria that must be considered for the preservation of urinary continence of patients after RRP.
 Running vesicourethral anastomosis increased the rate of early urinary incontinence. Both anastomosis techniques provided a similar rate of postoperative urine extravasation. VUA should only be one of the many criteria that must be considered for the preservation of urinary continence of patients after RRP.
  To investigate the association of genetic polymorphisms of 
  with postpartum depressive symptoms and analyze the risk factors for postpartum depressive symptoms in women following cesarean section.
 
  A total of 368 Chinese woman undergoing cesarean section were enrolled in this study. A cutoff of ≥10 for the Edinburgh Postnatal Depression Scale identified postpartum depressive symptoms. Genotypes of 
  , 
  
  , and 
  
  were determined using Sequenom MassArray single-nucleotide polymorphism (SNP) analysis. We analyzed the contribution of genetic factors (SNPs, linkage disequilibrium, and haplotype) to postpartum depressive symptoms and performed logistic regression analysis to identify all potential risk factors for postpartum depressive symptoms and define interactions between genetic and environmental factors.
 
  The incidence of postpartum depressive symptoms was 18.7% in this cohort. Univariate analysis suggested that 
  polymorphism at rs2873703 (TT genotype) and rs4801933 ((TT genotype) and 
  polymorphnce, stress during pregnancy, and prenatal depression are more likely to suffer from postpartum depressive symptoms.
  Strokes are devastating as there are no current therapies to prevent long-term neurological deficits. Previous studies reported that cerebroprotein hydrolysate (CH) plays a role in neuronal protection in acute phase after ischemic stroke, while the long-term effects of CH upon brain plasticity and neurological outcomes after stroke are still uncertain. To address these gaps, we assessed the effect of a new cerebroprotein hydrolysate, CH1, on long-term gray and white matter integrity as well as axonal plasticity in the late phase after ischemic stroke and the potential mechanisms.
 
  Adult male mice were subjected to permanent distal middle cerebral artery occlusion (dMCAO), followed by daily intraperitoneal injection of CH1 for 14 days. Motor function was measured weekly through behavioral neurological evaluations. Gray matter intensity and white matter intensity were examined by immunofluorescence staining. The sonic hedgehog (Shh) inhibitor cyclopamine (CYC) was injected to determine the involvement of the Shh pathway in the therapeutic effects of CH1.
 
  We found that intraperitoneal delivery of CH1, compared to vehicle administration, significantly improved long-term neurological outcomes at various times and promoted neuronal viability at 14 days but not at 28 days after stroke. Importantly, CH1 mitigated stroke-induced white matter injury and facilitated axonal plasticity in the late stage after stroke.
 
  These results unveil a previously unappreciated role for CH in the repair of white matter and brain plasticity after stroke.
 These results unveil a previously unappreciated role for CH in the repair of white matter and brain plasticity after stroke.