https://www.selleckchem.com/products/kya1797k.html People with upper limb amputation are potentially at increased risk of shoulder pain because they often perform compensatory movements to operate their prostheses and rely more heavily on their nonamputated limb for everyday activities. To describe the frequency, severity, associated factors, and implications of shoulder pain in people with unilateral major upper limb amputation who use prostheses. Cross-sectional, observational design. National recruitment of people living in the community. U.S. veterans and civilians (N=107) with unilateral major upper limb amputation. Not applicable. Shoulder pain (any, ipsilateral and contralateral to amputation), activity performance (Activities Measure for Upper Limb Amputation), health-related quality of life (Veterans RAND 12-Item Health Survey mental component summary [MCS] and physical component summary [PCS]), and disability (Quick Version of the Disabilities of the Arm, Shoulder and Hand Score [QuickDASH]). All participants completed a comprehensivtion associated with functional and quality of life implications. Among prosthesis users, the shoulder contralateral to the amputation was at greatest risk, with risk increasing with every year since amputation. In our sample of predominantly male veterans with major upper limb amputation, shoulder pain was a common condition associated with functional and quality of life implications. Among prosthesis users, the shoulder contralateral to the amputation was at greatest risk, with risk increasing with every year since amputation. Local-Area Cartilage Segmentation (LACS) software was developed to segment medial femur (MF) cartilage on MRI. Our current objectives were to 1) extend LACS to the lateral femur (LF), medial tibia (MT), and lateral tibia (LT), 2) compare LACS to an established manual segmentation method, and 3) visualize cartilage responsiveness over each cartilage plate. Osteoarthritis Initiative participants with symp