https://www.selleckchem.com/products/qnz-evp4593.html 3%) were secondary school pupils. The main issues addressed were the substance-use prevention program based on life skills development, Unplugged (55 schools) and screen time and cyberstalking (17 schools). This program achieved interprofessional education and practice, with health-student-delivered activities. Interdisciplinarity was a core strength of the “Health service”. Areas for improvement were the communication and the reimbursement of transportation expenses. This program achieved interprofessional education and practice, with health-student-delivered activities. Interdisciplinarity was a core strength of the “Health service”. Areas for improvement were the communication and the reimbursement of transportation expenses.Chronic bronchitis is associated with hypertrophy of airway submucosal glands and with mucus and squamous metaplasia of the surface epithelium. A historical review of research on these and other pathological changes is provided. Next, from annual reports of the Registrar-General's Office (and later the Office of National Statistics), death rates per unit population from acute and chronic bronchitis (a term that here includes chronic obstructive pulmonary disease [COPD]) are calculated for England and Wales from 1838 to the present. #link# It is argued that a large increase in the death rate between 1838 and 1879, from all forms of bronchitis combined, was due primarily to increased levels of atmospheric coal smoke, whereas a decrease from 1879 to 1935 was due to progressively cleaner air. Between 1935 and the mid-1960s, mortality from chronic bronchitis among men increased dramatically, after which it has fallen, a pattern that parallels changes in cigarette smoking. Finally, a brief historical review of the treatments for chronic bronchitis is presented.Redefining Therapy in Early COPD (RETHINC) is a 12-week multicenter, randomized, double-blind, placebo-controlled, paral