At post-treatment month 12, respective BMI changes BMI -12.13 (-8.34, -15.93); -16.04 (-11.7, 20.37); -2,76 (-3.84, -9.36) (p < 0.01). The two surgical groups experienced significant change in telomere length LOAGB-OSPAN 2.02 (1.61, 2.41), p = 0.001; LMGB-OAGB 2.07 (1.72, 2.43), p = 0.001; and HDER 0.28 (0.22, 0.78), p = 0.26. The surgical groups were also more effective in treating MetS components. There were no deaths. Adverse events LOAGB-OSPAN (n = 2) (Clavien-Dindo grade II); LMGB-OAGB (n = 8) (grade I (n = 6) and grade II (n = 2).
 
  Compared with hypocaloric diet therapy, both bariatric procedures resulted in greater BMI loss, and secondarily, a significant increase in telomere length, and greater MetS resolution.
 
  ClinicalTrials.gov , NCT03667469, registered on 11 September 2018.
 ClinicalTrials.gov , NCT03667469, registered on 11 September 2018.
  Body image, self-esteem, and masculinity are three interconnected constructs in men with prostate cancer, with profound effects on quality of life. This meta-synthesis aimed to evaluate all known qualitative studies published studying the effect of prostate cancer on these constructs.
 
  A systematic review utilising PubMed, Embase, MEDLINE, and PsycINFO databases up to May 2020 was conducted in line with PRISMA and ENTREQ guidelines. All qualitative studies of men's experiences with body image, self-esteem, and masculinity whilst living with prostate cancer were included. A thematic meta-synthesis was conducted to identify emergent descriptive and analytical themes under the main study constructs.
 
  Of 2188 articles identified, 68 were included. Eight descriptive themes were identified under two analytical themes 'Becoming a Prostate Cancer Patient' and 'Becoming a Prostate Cancer Survivor'. These described the distress caused by changes to body image, sexual functioning, sense of masculinity, and self-esteem, and the subsequent discourses men engaged with to cope with and manage their disease.  https://www.selleckchem.com/products/liraglutide.html  A key element was increased flexibility in masculinity definitions, and finding other ways to re-affirm masculinity.
 
  Prostate cancer has an important effect on men's health post-diagnosis, and we identified strong relationships between each construct evaluated. The role of hegemonic masculinity is important when considering men's coping mechanisms and is also a key factor when addressing these constructs in counselling post-treatment.
 
  This meta-synthesis provides key topics that uniquely affect prostate cancer survivors, enabling these patients to be effectively counselled, and have their concerns recognised by clinicians.
 This meta-synthesis provides key topics that uniquely affect prostate cancer survivors, enabling these patients to be effectively counselled, and have their concerns recognised by clinicians.
  Female carriers with X-linked chronic granulomatous disease (XL-CGD) who have < 10% reactive oxygen species (ROS) production due to profound X-chromosome inactivation (XCI or lyonization) are more susceptible to infections. We assessed ROS production in Taiwanese female carriers with XL-CGD to investigate whether the level of ROS correlated to their clinical features of infection, autoimmunity, and autoinflammation.
 
  Clinical course, ROS production, flavocytochrome b558 (Cyto b558) expression, and genetic analysis in carriers were investigated after identifying their index cases between 2004 and 2019.
 
  A total of 19 mothers (median 27years; range 25-60years) and three of four girls (range 4-6years) relative to 22 male index XL-CGD cases from 19 unrelated families were enrolled. Approximately half (8/19, 42%) of the mothers had novel one-allele mutations. Twenty-two of the 23 females were carriers. One carrier with de novo [Arg290X]CYBB who suffered from refractory salmonella sepsis and chorioretinitis re needed to validate our findings.
 One carrier had undetectable Cyto b558 expression and an extremely low ROS production, and consequently presented with an XL-CGD phenotype. One mother and her daughter experienced recurrent neck lymphadenitis despite having sufficient ROS production. Significant autoimmunity/autoinflammation did not develop in any of the carriers. Studies with a longer follow-up period are needed to validate our findings.
  Apitegromab (SRK-015) is an anti-promyostatin monoclonal antibody under development to improve motor function in patients with spinal muscular atrophy, a rare neuromuscular disease. This phase1 double-blind, placebo-controlled study assessed safety, pharmacokinetic parameters, pharmacodynamics (serum latent myostatin), and immunogenicity of single and multiple ascending doses of apitegromab in healthy adult subjects.
 
  Subjects were administered single intravenous ascending doses of apitegromab of 1, 3, 10, 20, 30mg/kg or placebo, and multiple intravenous ascending doses of apitegromab of 10, 20, 30mg/kg or placebo.
 
  Following single ascending doses, the pharmacokinetic parameters of apitegromab appeared to be similar across all dose groups, following a biphasic pattern of decline in the concentration-time curve. The mean apparent terminal t
  after single intravenous doses of apitegromab ranged from 24 to 31days across dose groups. Dose-related increases were observed in C
  following multiple ascending doses. Single and multiple apitegromab doses resulted in dose-dependent and sustained increases in serum latent myostatin, indicating robust target engagement. Apitegromab was safe and well tolerated, on the basis of the adverse event (AE) profile with no clinically meaningful changes in baseline vital signs, electrocardiograms, or clinical laboratory parameters and no anti-drug antibody formation.
 
  These results support continued investigation of apitegromab for the treatment of patients with milder forms (type2 and 3) of spinal muscular atrophy.
 These results support continued investigation of apitegromab for the treatment of patients with milder forms (type 2 and 3) of spinal muscular atrophy.
  The most direct means of glaucoma screening is to use cup-to-disc ratio via colour fundus photography, the first step of which is the precise segmentation of the optic cup (OC) and optic disc (OD). In recent years, convolution neural networks (CNN) have shown outstanding performance in medical segmentation tasks. However, most CNN-based methods ignore the effect of boundary ambiguity on performance, which leads to low generalization. This paper is dedicated to solving this issue.
 
  In this paper, we propose a novel segmentation architecture, called BGA-Net, which introduces an auxiliary boundary branch and adversarial learning to jointly segment OD and OC in a multi-label manner. To generate more accurate results, the generative adversarial network is exploited to encourage boundary and mask predictions to be similar to the ground truth ones.
 
  Experimental results show that our BGA-Net system achieves state-of-the-art OC and OD segmentation performance on three publicly available datasets, i.e., the Dice scores for the optic disc/cup on the Drishti-GS, RIM-ONE-r3 and REFUGE datasets are 0.