As a result, protonated g-C3N4/graphene oxide aerogel reveals an excellent NO removal ratio (46.1%) and low NO2 generation (2.4%), demonstrating its excellent promising for air pollution purification. Our current work affords novel innovative insight for the construction of monolithic photocatalysts to control the secondary pollution for environmental remediation.To develop a novel adsorbent that can efficiently and rapidly recover gold from the leaching solution of electronic appliances, thiourea-resorcinol-formaldehyde resin microspheres (TRF) were prepared by a one-pot solvothermal method. Fourier transform infrared (FT-IR), thermogravimetric (TGA), X-ray diffraction (XRD), Transmission Electron Microscope (TEM), X-ray photoelectron spectroscopy (XPS), scanning electron micrograph and energy dispersive X-ray spectroscopy (SEM and SEM-EDS) were used to analyze the morphology and physical properties of TRF microspheres. The first time, TRF was successfully used to capture gold ions. The results showed that it had very high absorption capacity (1432 mg·g-1), good selectivity (Au(III) ≫ Fe3+ > Ni2+ > Co2+ ≈ Cu2+ > Al3+ > Na+ ≈ K+) and excellent reuse performance for gold ions. Based on the study of adsorption isotherms and kinetics, Au(III) adsorption on TRF is mainly chemisorption and the adsorption sites are uniform. In acidic systems, Au(III) was reduced by TRF and deposited on TRF as elemental gold. This work provides the possibility to further develop the application of sulfur- and nitrogen-containing polymer materials in gold recovery from mixed metal solution.Antimicrobial resistance is an imminent threat worldwide. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the "superbug" family, manifesting resistance through the production of a penicillin binding protein, PBP2a, an enzyme that provides its transpeptidase activity to allow cell wall biosynthesis. PBP2a's low affinity to most β-lactams, confers resistance to MRSA against numerous members of this class of antibiotics. An Achilles' heel of MRSA, PBP2a represents a substantial target to design novel antibiotics to tackle MRSA threat via inhibition of the bacterial cell wall biosynthesis. In this review we bring into focus the PBP2a enzyme and examine the various aspects related to its role in conferring resistance to MRSA strains.  https://www.selleckchem.com/  Moreover, we discuss several antibiotics and antimicrobial agents designed to target PBP2a and their therapeutic potential to meet such a grave threat. In conclusion, we consider future perspectives for targeting MRSA infections.Recent preclinical studies have shown that activation of the serotonin 5-HT7 receptor has the potential to treat neurodevelopmental disorders such as Fragile X syndrome, a rare disease characterized by autistic features. With the aim to provide the scientific community with diversified drug-like 5-HT7 receptor-preferring agonists, we designed a set of new long-chain arylpiperazines by exploiting structural fragments present in clinically approved drugs or in preclinical candidates (privileged scaffolds). The new compounds were synthesized, tested for their affinity at 5-HT7 and 5-HT1A receptors, and screened for their in vitro stability to microsomal degradation and toxicity. Selected compounds were characterized as 5-HT7 receptor-preferring ligands, endowed with high metabolic stability and low toxicity. Compound 7g emerged as a drug-like 5-HT7 receptor-preferring agonist capable to rescue synaptic plasticity and attenuate stereotyped behavior in a mouse model of Fragile X syndrome.Food adulteration is a growing concern worldwide. The collation and analysis of food adulteration cases is of immense significance for food safety regulation and research. We collected 961 cases of food adulteration between 1998 and 2019 from the literature reports and announcements released by the Chinese government. Critical molecules were manually annotated in food adulteration substances as determined by food chemists, to build the first food adulteration database in China (http//www.rxnfinder.org/FADB-China/). This database is also the first molecular-level food adulteration database worldwide. Additionally, we herein propose an in silico method for predicting potentially illegal food additives on the basis of molecular fingerprints and similarity algorithms. Using this algorithm, we predict 1919 chemicals that may be illegally added to food; these predictions can effectively assist in the discovery and prevention of emerging food adulteration.In this study, a murine monoclonal antibody (mAb) of 6D2-G10 against bacitracin zinc (BAC) was produced and applied to an immunochromatographic strip (ICS) for the initial detection of BAC in milk. The ICS with a cut-off value of 25 ng/mL could be perceived by the naked eye within 10 min. With the assist of the strip reader, the limit of detection (LOD) was measured as 0.82 ng/mL, the half-maximal inhibitory concentration (IC50) was recorded as 3.16 ng/mL, and the linear detection range was from 0.97 to 10.30 ng/mL. The recoveries ranged from 87.7% to 96.0% with the highest coefficient of variation (CV) of 9.1% in the intra-assay and from 84.3% to 90.2% with the highest CV of 10.7% in the inter-assay. In short, the established ICS provided a serviceable analytical tool for qualitatively and quantitatively monitoring BAC in milk.Objectives To compare obtained and predicted inspiratory and expiratory muscle strength between frail, pre-frail, and non-frail older people; to examine the association between inspiratory and expiratory muscle strength and frailty in older people; and to determine cut-off points for inspiratory and expiratory muscle strength for discriminating frailty in older people. Methods A cross-sectional study was conducted with 379 community-dwelling older adults. Frailty was assessed using Fried's phenotype, while inspiratory and expiratory muscle strength were measured with maximum inspiratory and maximum expiratory pressures. Inferential analyses were performed using paired Student t-tests, one-way analysis of variance (ANOVA) tests, and a multinomial logistic regression model. ROC curves were constructed to establish cut-off points of maximum inspiratory and expiratory pressures for discriminating frailty and pre-frailty. Results Frail and pre-frail participants presented significantly lower mean inspiratory and expiratory pressures compared to non-frail participants; values were significantly lower than predicted.