During laparoscopic cholecystectomy operations, increases in intra-abdominal, intra-thoracic and intracranial pressures(ICP) can be seen after pneumoperitoneum created for surgical imaging. Orbital ultrasonography(USG), which has been developed in recent years, is a method that can evaluate the ICP by measuring the optic nerve sheath diameter (ONSD) from the eyeball. In our study, we aimed to evaluate whether different intraabdominal pressure values created during laparoscopic cholecystectomy operations correlate with ICP by measuring ONSD. The study included a total of 90 patients with American Society of Anesthesiologists (ASA) physical status classification I (ASA I) and II (ASA II) and ages from 18-65 years with laparoscopic cholecystectomy planned. After patients were intubated, in the 5th minute bilateral ONSD measurements were performed. https://www.selleckchem.com/products/trastuzumab.html The same measurements were performed in the 15th and 30th minutes after CO2 insufflation and additionally 10 minutes after CO2 was released at the end of the operase at risk of ICP increase, during laparoscopic surgery. USG guided ONSD measurements appear be a guide to ensure optimization of intraabdominal pressures and safe anesthesia administration for patients, especially those at risk of ICP increase, during laparoscopic surgery. Adipocytokine, an adipocyte-derived protein, well-known to be involved in the pathogenesis of breast cancer. We aimed to measure the mRNA expression of resistin, TNF-?, interleukin six and eight (IL-6, and IL-8), and estrogen receptor alpha (ER-?) in peripheral blood mononuclear cells (PBMCs) of women with and without breast cancer. Blood samples were obtained from 32 women with breast cancer and 18 women without breast cancer. The PBMCs were isolated from whole blood using density gradient centrifugation. Target genes mRNA expression was measured by reverse-transcription polymerase chain reaction (RT-PCR). Body mass index was calculated, and the clinicopathological characteristics of subjects were also determined by histopathological examination. Our results indicated that the mRNA expression of resistin and IL-6 in PBMCs of breast cancer patients was significantly increased (approximately 3.5-fold, and 15-fold respectively) compared to healthy controls. Resistin expression was significantly associated with inflammatory markers including TNF-?, IL-6, IL-8, but not with anthropometric indices. Logistic regression analysis revealed that these adipokines were not associated with breast cancer. Based on the ROC curve analysis the diagnostic performance of IL-6 was significant (0.825, 95% CI 0.549-0.947), thus, it might be considered as a breast cancer biomarker that reflecting an advanced and inflammatory stage of the disease. Breast cancer is associated with increased expression of adipocytokines in PBMCs. Our results suggested that a PBMC-based gene expression test may be developed to detect breast cancer early. Breast cancer is associated with increased expression of adipocytokines in PBMCs. Our results suggested that a PBMC-based gene expression test may be developed to detect breast cancer early. Approximately 40 million individuals worldwide have been infected with SARS-CoV-2, the virus responsible for the novel coronavirus disease-2019 (COVID-19). Despite the current literature about the cardiac effects of COVID-19 in children, more information is required. We aimed to determine both cardiovascular and arrhythmia assessments via electrocardiographic and echocardiographic parameters. We evaluated 70 children who were hospitalized with COVID-19 infections and 70 children as the normal control group through laboratory findings, electrocardiography (ECG), and transthoracic echocardiography (TTE). We observed significantly increased levels of Tp-Te, Tp-Te/QT, and Tp-Te/QTc compared with the control group. Twenty-five of 70 (35.7%) patients had fragmented QRS(fQRS) without increased troponin levels. None of the patients had pathologic corrected QT(QTc) prolongation during the illness or its treatment. On TTE, 20 patients had mild mitral insufficiency, among whom only five had systolic dysfunction (ejection fraction <55%). There was no significant difference between the patient and control groups, except for isovolumic relaxation time (IVRT) in terms of mean systolic and diastolic function parameters. The IVRT of COVID patients was significantly lower than that of control group. Despite all the adult studies, the effects of COVID?19 on myocardial function are not well established in children. The thought that children are less affected by the illness may be a misconception. Despite all the adult studies, the effects of COVID?19 on myocardial function are not well established in children. The thought that children are less affected by the illness may be a misconception. High flow nasal cannula (HFNC) was mostly used in intensive care units with few studies in other departments. We hypothesized that HFNC applied at wards is beneficial for acute respiratory failure in hematological malignancy patients. The study is a single center, randomized controlled study. Inclusion criteria were hypoxemic respiratory failure and hematological malignancy. Patients were randomized to either venturi mask/nasal cannula oxygen treatment or HFNC. One hundred patients were included into the study. Median age was 58.5 (18-86) years and APACHE II score was 17 (5-29). HFNC group was 51 patients and oxygen treatment group 49 patients. P/F ratios were similar between the groups throughout the study period. Endotracheal intubation was required in 10 (20.0%) patients in oxygen group and 17 (33.0%) patients in HFNC group (p=0.14). A total of 17 (35.0%) patients in oxygen group and 17 (33.0%) patients in HFNC group received non-invasive mechanical ventilation (p=0.97). Median VAS comfort scores at 2nd and 24th hours were not different between groups. Twenty-eight-day mortality rate was 36.7% (18 deaths) in standard group and 45.0% (23 deaths) in HFNC group (p=0.39). HFNC applied in wards is not superior to standard oxygen treatment for acute respiratory failure in hematological malignancy patients. HFNC applied in wards is not superior to standard oxygen treatment for acute respiratory failure in hematological malignancy patients.