02 [1.21] events). Overall, self-reported diagnosed concussions and medical record diagnosed concussion histories had a 'fair' level of agreement (k=0.274; SE [0.076]), p=.001). Self-reported lifetime concussion history was signicantly negatively correlated with recall of concussions.Conclusions Initial concurrent validity of the MTBIIM was found to be fair with the average athlete under-reporting the number of clinically diagnosed concussions.An increment in mental health problems related to social isolation strategies was evinced in several populations, however few investigations address this problem in students. This study aimed to analyze the relationship between insomnia, worry, coping strategies, and academic engagement in subjects pursuing a university degree in Argentina during the first month of compulsory social isolation against the COVID-19 pandemic. Self-report online questionnaires were administered to 584 participants Insomnia Severity Index, Penn State Worry Questionnaire, Coping Responses Inventory, Utrecht Work Engagement Scale for Students. Demographic data was recorded. Statistics included bivariate and multivariate techniques. Prevalences of 45% for subthreshold insomnia, 23% for moderate insomnia, and 4% for severe insomnia were found. The severe insomnia group presented higher levels of worry and cognitive avoidance strategies. Insomnia was also associated with daytime concerns. The group without insomnia was more vigorous in their academic engagement. Being physically active was associated with lower sleep problems. Insomnia prevalence is high in socially isolated university students.  https://www.selleckchem.com/products/zotatifin.html  Cognitive avoidance coping strategies are associated with worry, which leads to an alert state that makes sleep difficult. These findings should be taken into account by academic institutions to define their pedagogic strategies.Chirality is a fundamental property in many biological systems. Motivated by previous observations of helical aortic blood flow, aortic tissue fibers, and propagation of aortic dissections, we introduce methods to characterize helical morphology of aortic dissections. After validation on computer-generated phantoms, the methods were applied to patients with type B dissection. For this cohort, there was a distinct bimodal distribution of helical propagation of the dissection with either achiral or exclusively right-handed chirality, with no intermediate cases or left-handed cases. This clear grouping indicates that dissection propagation favors these two modes, which is potentially due to the right-handedness of helical aortic blood flow and cell orientation. The characterization of dissection chirality and quantification of helical morphology advances our understanding of dissection pathology and lays a foundation for applications in clinical research and treatment practice. For example, the chirality and magnitude of helical metrics of dissections may indicate risk of dissection progression, help define treatment and surveillance strategies, and enable development of novel devices that account for various helical morphologies.NEW & NOTEWORTHY A novel definition of helical propagation of type B aortic dissections reveals a distinct bimodality, with the true lumen being either achiral (nonhelical) or exclusively right-handed. This right-handed chirality is consistent with anatomic and physiological phenomena such as right-handed twist during left ventricle contraction, helical blood flow, and tissue fiber direction. The helical character of aortic dissections may be useful for pathology research, diagnostics, treatment selection, therapeutic durability prediction, and aortic device design.Recently, an increasing number of researchers propose to use restricted mean survival time (RMST) to evaluate medical treatment outcomes when the proportional hazards assumption is in doubt. Using the empirical likelihood ratio for the Kaplan-Meier mean, we show how the statistical analysis for the RMST and difference/ratio of two RMSTs can be obtained. Examples are given using R software and package emplik. We argue that the confidence intervals produced with this new method has several intrinsic advantages over the current method implemented in R package survRM2. A simulation is also included.Primary Objective To understand the experiences of family members of individuals in a locked-in state (LIS), minimally conscious state (MCS), or vegetative state (VS) with the health-care system when caring for their family member.Research Design The study adopted a qualitative descriptive approach drawing on central tenets of constructivist grounded theory described by Charmaz. Our analysis drew on emphasizing connections between theory, concepts, and empirical data using a constant comparative method.Methods and Procedures Semi-structured interviews were conducted with family members of individuals in a LIS, MCS, or VS. Participants were recruited between June 2014 and December 2016.Main Outcomes and Results 22 interviews were conducted, which comprised interviews with 12 family members. The following themes were identified care coordination challenges, lack of flexibility in health-care policies, and inappropriate care settings.Conclusions Family members of individuals in a LIS, MCS, or VS described playing a significant role in the lives of their family member. Based on the results of this study, flexibility in health-care policies and/or programming should be adopted in the face of the challenges identified. Implementation of interventions to support caregivers and transitions is increasingly important.Cognitive deficits are common in patients with chronic heart failure (HF), but little attention has been given to the investigation of prospective memory (PM) - the ability to execute delayed intentions. Importantly, many aspects of PM are crucial for patient implementation of HF self-care behaviours. Here we provide a replication of our original work involving PM in patients with HF. We compared a group of 51 HF patients to 41 closely matched controls. The primary outcome measure was a laboratory test of PM, Virtual week, which closely simulates PM tasks in daily life. A series of background cognitive tests were also administered. Consistent with our previous work, the HF group had significant PM impairment compared to controls, and these difficulties were generalised across different types of PM tasks. Surprisingly, we did not find any differences in the background cognitive tasks between groups. Compared to controls, the HF group had significant and similar sized deficits on all task parameters assessed (event, time, regular, irregular) of PM function, which likely impacts engagement in HF self-care.