Molecular docking studies were performed to assess the bonding mode of synthesized compounds. In case of antioxidant activity study, the compounds L1H, Ni(L1)2, Cu(L1)2, Cu(L2)2 and Ni(L2)2 exhibited significant scavenging activity with good percentage when compared with remaining tested compounds. © 2020 Elsevier B.V. All rights reserved.Objective This study examines the intergenerational transmission of socioeconomic status among people who have a biological father as well as a stepfather. In particular, this study investigates how the relative importance of biological fathers and stepfathers in the transmission process depends on the time in coresidence, postdivorce contact frequency, and parental involvement. © 2019 The Authors. Journal of Marriage and Family published by Wiley Periodicals, Inc. on behalf of National Council on Family Relations.Objective This study examines the support from stepparents to adult children and considers the role of the composition of the parent network, that is, the presence or absence of the biological mother or father. Background Going beyond previous research that compared the support provided by different types of parental households, this study provides deeper insights into adult stepfamily dynamics by considering support transfers on the stepparent-stepchild dyad level. Method The analyses were based on data from the Ouders en Kinderen in Nederland (Parents and Children in the Netherlands) survey, which was conducted among a stratified random sample of Dutch adults (aged 25-45) with stepparents reporting on support from each of their stepparents (N = 4,351) and biological parents (N = 5,460) separately. Results The results revealed different stories for stepmothers and stepfathers. Within-child analyses showed that, controlled for the duration of coresidence, children received less types of support from their stepmother than from their biological mother, whereas among fathers, the stepfather provided more. When compared between children, stepmothers provided less types of support if their stepchild's biological mother was still alive, whereas stepfathers' support was unaffected by the biological father's presence. Stepparents of both genders provided less types of support if their partner (i.e., the child's biological parent) was deceased. Conclusion These findings articulate the central role of the biological mother in postseparation families and the ambiguous position of the stepmother and "widowed stepparents." © 2019 The Authors. Journal of Marriage and Family published by Wiley Periodicals, Inc. on behalf of National Council on Family Relations.The use of corticosteroids in the management of septic shock has been a highly debated topic for quite some time. Corticosteroids have the ability to combat hyperinflammatory and exaggerated vasodilatory responses, as well as to sensitize adrenergic receptors to decrease the duration of shock. While helpful clinically, this has not translated to consistent mortality benefits. Conflicting results from 2 landmark trials published in 2002 and 2008 have led to varying clinical practices, and a clearly defined role of corticosteroids in septic shock is lacking. A decade later, an influx of new data derived from 2 more large trials continues to echo diverging viewpoints regarding patient mortality. In combination with fluctuating study designs (eg, adjunctive therapies and shock management) and patient populations (eg, illness severity), generalized conclusions are still difficult to draw. Despite these challenges, this review critically analyzes recently published data in the context of historical debate to provide an updated comment on the role of corticosteroids in septic shock. In summary, hydrocortisone therapy is likely to demonstrate maximal benefit when initiated on patients with septic shock and organ failure refractory to vasopressor therapy and should be used judiciously in other settings as it comes without a demonstrated benefit in mortality and increased potential for adverse effects. © The Author(s) 2019.Purpose The purpose of this study was to compare the volume of fluid removal associated with and without 25% albumin administration in conjunction with hemodialysis. Methods This retrospective, cohort study was conducted at a large academic medical center over a 6-month period to compare the net fluid amount removed (mL) during hemodialysis between patients administered 25% albumin and those without albumin. Results A total of 238 patients consisting of 973 unique hemodialysis sessions were evaluated. The mean overall net fluid removed by hemodialysis in the 25% albumin and no albumin groups were 1242 mL and 1899 mL, P less then .001, respectively. No albumin group had significantly higher mean fluid losses compared with 25% albumin for a total dose of either 25 g (P = .001) or 50 g (P = .001).  https://www.selleckchem.com/products/FK-506-(Tacrolimus).html  There were no significant differences in mean fluid loss between the no albumin group and patients receiving 75 g or 100 g of albumin. Post hoc analysis failed to demonstrate a dose-dependent response in those patients receiving 25% albumin and no albumin. Conclusion Hyperoncotic albumin administered during hemodialysis sessions reduced net fluid loss associated with hemodialysis. The findings of this study do not support the routine use of 25% albumin to improve fluid removal during dialysis. © The Author(s) 2019.Background The recent addition of intranasal medication options for procedural sedation and analgesia has decreased the need for additional painful procedures such as intravenous lines for medication administration. Intranasal fentanyl (INF) has been used in the prehospital setting, as well as in the emergency department for several years, and is increasingly utilized in other locations such as the neonatal intensive care unit (NICU). A paucity of data exists in these smallest children, so we sought to explore trends in INF use in our NICU. Objective The objective of the study was to describe INF use in the NICU from December 2014 to December 2017. Design/Methods A retrospective cohort study was conducted of patients receiving INF in the NICU of a large free-standing quaternary inner-city children's hospital from December 2014 to 2017. Demographic data were abstracted from the medical record including gestational age on administration, post-menstrual age, day of life on administration, sex, medication initial and total dose, reported indication, and documented adverse events.