To assess the long-term recovery of sensation in the lower lip after mandibular resection without reconstruction of the inferior alveolar nerve.
 
  Thirty patients who had mandibular resection carried out without reconstruction of the inferior alveolar nerve were examined after an interval ranging from 6 to 33 years.
 
  Only 1 patient, seen 10 years after resection, was totally numb over the distribution of the inferior alveolar nerve. The other 29 patients had some return of sensation and many had a significant return, though it may take several years to reach the final result. Utilizing the MRC scale 70% of patients achieved S3 (return of superficial cutaneous pain and tactile sensibility without over response) CONCLUSION This study can serve as a baseline for comparison with patients who have had mandibular resection with reconstruction of the inferior alveolar nerve to assess if this procedure improves the outcomes.
 Only 1 patient, seen 10 years after resection, was totally numb over the distribution of the inferior alveolar nerve. The other 29 patients had some return of sensation and many had a significant return, though it may take several years to reach the final result. Utilizing the MRC scale 70% of patients achieved S3 (return of superficial cutaneous pain and tactile sensibility without over response) CONCLUSION This study can serve as a baseline for comparison with patients who have had mandibular resection with reconstruction of the inferior alveolar nerve to assess if this procedure improves the outcomes.
  Healthcare products (HP) have a significant carbon footprint that must be included by regulation in the facility's purchasing policy. A national overview of the inclusion of environmental criteria (EC) in the public procurement (PP) of HP in hospitals has been carried out.
 
  Thirty EC were identified in the literature.  https://www.selleckchem.com/products/apr-246-prima-1met.html  Two questionnaires were proposed (i) for buyers that analyze the level of "importance" and "ease of application" for public tenders (PT), and (ii) for suppliers that declare their commitments and evidence.
 
  Six regional buyers and 28 suppliers participated. Buyers recognize the "importance" of sustainable development (SD) but are more reticent about the "applicability" of EC in PT. The environmental rating remains low on average 4.38 (0.25 - 10.00) % of the total rating. Only 12 EC are integrated within some PT. Suppliers report a high and diversified commitment to SD 18 suppliers sent 474 evidence. Buyers and suppliers converge on the optimization of primary packaging and the establishment of a minimum order or delivery group.
 
  Since the efficiency of PP is inevitable, EC that combines SD and savings should be prioritized. The integration of additional EC, simple and easily documented, allowing cost containment for both suppliers and buyers, is possible to promote sustainable purchasing.
 Since the efficiency of PP is inevitable, EC that combines SD and savings should be prioritized. The integration of additional EC, simple and easily documented, allowing cost containment for both suppliers and buyers, is possible to promote sustainable purchasing.The basic objective of this study is to propose a short, reliable, mass compatible ultra-performance liquid chromatography (UPLC) method to confirm the identity of impurities and to estimate the assay and purity of Tirofiban simultaneously in aqueous injection (5 mg/100 mL bag). Aqueous formulations are susceptible to oxidation, hence the possible oxidative degradation impurities of Tirofiban were studied in this experiment by using UPLC coupled with Photodiode Array/Quadrupole Dalton Analyzer (PDA/QDa) detectors. The required separations were achieved in the column ACQUITY HSS T3 (100 x 2.1) mm, 1.7 µm, operated at 30 ºC by using 0.02 % Triethyl amine (TEA) in water, pH 2.8 with formic acid as solution-A and 0.1 % formic acid in 91 acetonitrile, water as solution-B. Binary gradient flow is delivered at the rate of 0.5 mL/min and the detection of impurities specifically carried out at 227nm using empower3 software. RP-UPLC/PDA with QDa detector was used for the experiment. The method was linear and accurate from the concentrations 0.04 to 0.38 µg/mL for impurity-A and 0.04 to 75 µg/mL for Tirofiban. The major unknown degradation impurity generated during the oxidative degradation has been identified as N-oxide derivative (Impurity-B) [(M+H)+ 455.1] by using QDa detector operated in an electro spray positive ion mode by applying a voltage of 0.8kV. This method was further validated as per ICH Q2 (R2) guidelines. Hence, the proposed method is said to be a fast, sensitive and comprehensive technique which could give a clear idea about the assay and impurity profile of Tirofiban injection.
  Information available on the packaging of drugs indicated for patients electrolytes replenishment differs from one manufacturer to another. They relate, for example, the unit chosen to express elemental electrolyte concentration. These differences constitute a risk factor for medication errors. This article proposes a clinical decision support tool which defines dose equivalences between the oral and injectable formulation galenic forms for medications providing phosphorus, calcium and magnesium and a calculated replenishment ratio.
 
  The amounts of elemental electrolyte were determined from the information contained on the packaging and the summaries of product characteristics. Only the specialties of our hospital drug formulary were studied. For each element, the replenishment ratio was determined from published data.
 
  Equivalence tables were created for the phosphorus, calcium and magnesium between oral and injectable formulation. A clinical decision support tool was developed from these data.
 
  The use of this tool is a first way to reduce the risk of medication errors. It remains to determine the conditions for its dissemination and evaluation. This issue raises the questions of the exclusive use of the millimole unit on packaging and for prescription, and that of the integration of this type of tool into prescription software and decision support systems.
 The use of this tool is a first way to reduce the risk of medication errors. It remains to determine the conditions for its dissemination and evaluation. This issue raises the questions of the exclusive use of the millimole unit on packaging and for prescription, and that of the integration of this type of tool into prescription software and decision support systems.