Participants nominated network ties that paralleled their own substance use (e.g., the majority of simultaneous users' networks ties were also simultaneous users).
 
  Having a larger percentage of friends who use cannabis and alcohol is associated with increased odds of using both substances at the same time, perhaps because it gives access to both substances at the same time.  https://www.selleckchem.com/products/monomethyl-auristatin-e-mmae.html  Interventions should account for amount of exposure to alcohol and cannabis use from network members. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
 Having a larger percentage of friends who use cannabis and alcohol is associated with increased odds of using both substances at the same time, perhaps because it gives access to both substances at the same time. Interventions should account for amount of exposure to alcohol and cannabis use from network members. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
  The present study examines how perceptions of peer use, risks of use, and benefits to oneself and others from marijuana use are associated with past-month marijuana use and intentions to use marijuana socially among American Indian (AI) youth.
 
  The American Drug and Alcohol Survey (ADAS), a measure of substance use and related factors, was administered to AI youth living on or near reservations across six geographic regions (n = 3,498, 49.5% female, M age = 14.8).
 
  Greater perceived peer use was significantly associated with more frequent past-month marijuana use (b = .05, p = .038) and intentions to use marijuana socially (b = .74, p < .001). Greater benefits to oneself were associated with greater marijuana use intentions (b = .35, p < .001). Greater perceived risks and benefits to others were significantly associated with less frequent past-month use (b = -.02, p = .002; b = -.01, p = .007, respectively) and intentions to use marijuana socially (b = -.05, p = .001; b = -.03, p = .002, respectivelefforts for youth who have or have not used marijuana. (PsycInfo Database Record (c) 2022 APA, all rights reserved).The Risk-Need-Responsivity (RNR) principles of effective correctional service that are well supported in the general offending literature have less often been applied to the assessment and treatment of intimate partner violence (IPV). Well validated IPV risk assessment tools are now widely available, and IPV treatment programs that match treatment intensity to assessed risk have shown promising pre-to-post treatment effects. The present study builds on the study of RNR principles in IPV by exploring criminogenic needs and their relation to recidivism and to recently proposed treatment intensity categories derived from an IPV risk assessment tool. We reanalyzed data from 1,421 men with a police report of IPV in the original Ontario Domestic Assault Risk Assessment (ODARA) dataset, to explore the prevalence of antisocial personality traits, procriminal attitudes, substance use, poor relationships, and work/school problems and their relation to IPV recidivism and ODARA-based treatment intensity categories. Needs were present in 17% (procriminal attitudes) to 42% (substance use) of men. All needs except poor relationships were positively related to IPV recidivism; in logistic regression analyses, antisocial personality traits (OR = 1.80) and poor relationships (OR = 0.61) incrementally predicted IPV recidivism over the ODARA (OR = 1.40). Men placed in higher treatment intensity categories based on the risk assessment score had more criminogenic treatment needs. Findings support using the ODARA to select individuals for the most intensive IPV treatment, and suggest that assessing and treating criminogenic needs may improve IPV treatment outcomes. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Herein, we describe the development of 2D self-healing small-scale swimmers capable of autonomous propulsion and "on-the-fly" structural recovery in large containers. Incorporation of magnetic Nd2Fe14B microparticles in specialized printed strips results in rapid reorientation and reattachment of the moving tail to its complementary broken static piece to restore the original swimmer structure and propulsion behavior. The swimmers display functional recovery independent of user input. Measurements of the magnetic hysteresis and fields were used to assess the behavior of the healing mechanism in real swimming situations. Damage position and multiple magnetic strip patterns have been examined and their influence upon the recovery efficiency has been compared. Owing to its versatility, fast response, and simplicity the new self-healing strategy represents an important step toward the development of new "on-the-fly" repairing strategies for small-scale swimmers and robots.Oral delivery of insulin remains a challenge owing to its poor permeability across the small intestine and enzymatic digestion in the gastrointestinal tract. In a previous study, we identified a small intestine-permeable cyclic peptide, C-DNPGNET-C (C-C disulfide bond, cyclic DNP peptide), which facilitated the permeation of macromolecules. Here, we showed that intraintestinal and oral coadministration of insulin with the cyclic DNP derivative significantly reduced blood glucose levels by increasing the portal plasma insulin concentration following permeation across the small intestine of mice. We also found that protecting the cyclic DNP derivative from enzymatic digestion in the small intestine of mice using d-amino acids and by the cyclization of DNP peptide was essential to enhance cyclic DNP derivative-induced insulin absorption across the small intestine. Furthermore, intraintestinal and oral coadministration of insulin hexamer stabilized by zinc ions (Zn-insulin) with cyclic D-DNP derivative was more effective in facilitating insulin absorption and inducing hypoglycemic effects in mice than the coadministration of insulin with the cyclic D-DNP derivative. Moreover, Zn-insulin was more resistant to degradation in the small intestine of mice compared to insulin. Intraintestinal and oral coadministration of Zn-insulin with cyclic DNP derivative also reduced blood glucose levels in a streptozotocin-induced diabetes mellitus mouse model. A single intraintestinal administration of the cyclic D-DNP derivative did not induce any cytotoxicity, either locally in the small intestine or systemically. In summary, we demonstrated that coadministration of Zn-insulin with cyclic D-DNP derivative could enhance oral insulin absorption across the small intestine in mice.