https://www.selleckchem.com/products/kd025-(slx-2119).html The outbreak of COVID-19 pandemic worldwide has brought huge challenges to urban governance. Whether the smart city projects play a significant role in the COVID-19 prevention and control process is a question worthy of attention. Based on the data of COVID-19 confirmed cases and the smart cities projects investment in China cities, our empirical results show that smart city projects have significantly reduced the number of COVID-19 confirmed cases. Specifically, for every 1 million yuan increase in smart city investment per 10,000 people, the number of COVID-19 confirmed cases per 10,000 people would decrease by 0.342. The heterogeneity analysis results show that the effect of the smart city projects on COVID-19 in the spread phase inside a city is stronger than that in the input phase. In addition, the effect differs for cities with different population sizes. This study provides quantitative evidence of the impact of smart city projects on COVID-19 prevention and control. With the coronavirus disease 2019 (COVID-19) pandemic spreading across the world, protective measures for containing the virus are essential, especially as long as no vaccine or effective treatment is available. One important measure is the so-called or . In this paper, we propose an agent-based numerical simulation of pedestrian dynamics in order to assess the behavior of pedestrians in public places in the context of contact transmission of infectious diseases like COVID-19, and to gather insights about exposure times and the overall effectiveness of distancing measures. To abide by the minimum distance of 1.5 m stipulated by the German government at an infection rate of 2%, our simulation results suggest that a density of one person per 16m or below is sufficient. The results of this study give insight into how physical distancing as a protective measure can be carried out more efficiently to help reduce the spread of COVID-19. The re