Walnuts (fruits Juglans regia, L.) belong among to the most spread, commercially grown tree nuts in the world. Nuts have grown higher attention in last years as valuable sources of essential elements; they are rich in non-essential fatty acids, proteins, fibre, plant sterols and minerals including potassium and magnesium and antioxidants. Determination of elements distribution in nuts is required not only for evaluation of total intake of essential elements in our food, but it is also useful for gaining data on contamination of foodstuffs by risk elements, but also for monitoring of heavy metal contamination in foodstuffs. Walnut samples were taken from three selected areas in Slovakia. The first location is in the vicinity of the cities Strážske, Humenné and Vranov nad Topľou, the second one is situated close to the city of Prievidza and the last one is close to the city of Vráble. The results of evaluation showed that the content of the elements monitored in location of Vráble did not exceed the limits set by the Regulation of Ministry of Health of Slovak Republic No 2/1994. In the half of samples taken from the location of Strážske, higher content of cadmium as the permitted limit has been found. The samples exceeded the amounts allowed by the Regulation No 2/1994 in contaminated area called "The dangerous triangle". Potential consumption of these walnuts could negatively affect human organism, but only if the kernels from the exact locality would be consumed in very high daily amounts (100-fold higher intake as daily intake according to the Statistical Office of SR).
  Diffuse long coronary lesions require long overlapping stents which produce less than optimal long-term results. Sizing of long stents becomes difficult owing to tapering of coronaries and overlapping with excessive metal which makes restenosis a nagging problem on long-term follow-up. The optimal stent sizing becomes even more important when left main (LM) needs to be treated along with left ascending artery (LAD) or left circumflex artery (Lcx). The chronic total occlusions (CTO) represent other complex diffuse coronary lesions which not only require higher expertise and better hardware but also usually long lengths of overlapping stents. The long-tapered sirolimus-eluting stent system (BioMime Morph) has been successfully used in long diffuse lesions in individual coronaries including CTO but the use of the same in LM-LAD/LM-Lcx diffuse lesions has not been explored well where its tapered design can really be favourable.
 
  We here present a case of a 51-year-old hypertensive male presented with NSTEMI anging helps in better optimisation of stents.Every day around the country, patients are discharged from hospitals without difficulty, as the interests of the hospital and the patient tend to align both the hospital and the patient want the patient to leave and go to a setting that will promote the patient's continued recovery. In some cases, however, this usually routine process does not go quite as smoothly. Patients may not want to leave the hospital, or they may insist on an unsafe discharge plan. In other cases, there may simply be no good place for the patient to go. These complex hospital discharge situations often involve ethical, legal, financial, and practical considerations, but the ethical issues inherent in these dilemmas have received only sporadic attention from clinical ethicists at best, leaving patients, providers, administrators, and caregivers unsure about what to do. When the ethical issues are in fact brought to light, analysis usually proceeds based on a consideration of the principles of autonomy, beneficence, nonmaleficence, and icult discharge.
  Spontaneous intracranial hypotension (SIH) is rare but can lead to life-threatening complications including cerebral venous thrombosis (CVT). The concurrence of CVT and SIH raises questions regarding priority.
 
  We present the case of a 52-year-old woman who developed sudden left-sided hemiparesis and generalized tonic-clonic seizures. She experienced progressive orthostatic headaches over the prior 2 weeks. Imaging showed thrombosis in the left transverse and sigmoid sinuses, bilateral subdural hematomas, and a cervicothoracic cerebrospinal fluid leak. Low molecular weight heparin was administered, but it was discontinued 2 days later due to subarachnoid hemorrhage. She was transferred to our hospital where an epidural blood patch was applied immediately, which resulted in complete symptom relief.
 
  CVT is a rare complication of SIH that may result in devastating consequences. Treatment of SIH should be the primary focus. Prompt diagnosis and EBP application can result in a good outcome.
 CVT is a rare complication of SIH that may result in devastating consequences. Treatment of SIH should be the primary focus. Prompt diagnosis and EBP application can result in a good outcome.In the original article there are errors in the authors' affiliations.To assess atrial function in Fontan patients using cardiac MRI (CMR) and determine the relationships between atrial function, hemodynamics, and clinical outcomes. Two center chart review identified all Fontan patients with technically adequate CMR to assess atrial function within 1 year of cardiac catheterization and age-matched controls with CMR.  https://www.selleckchem.com/products/Eloxatin.html  Atrial reservoir, conduit, and pump global longitudinal strain and strain rate measurements were determined by CMR. Univariate and stepwise multivariable analysis were conducted to detect associations of atrial function measures with ventricular end diastolic pressure (EDP), cardiac index (CI), exercise capacity, liver stiffness and a composite outcome of heart transplantation, ventricular assist device or death. The study cohort was comprised of 33 Fontan patients and 30 age-matched controls. Fontan patients had lower atrial reservoir and conduit strain, and lower reservoir, conduit, and pump strain rate compared to age-matched controls. Atrial conduit strain was negatively associated with EDP and lower atrial pump-to-conduit strain ratio was associated with lower cardiac index in multivariable analysis. Lower atrial pump strain was associated with lower exercise capacity (per 1% increase β = 2.3 ± 0.9, p = 0.03) and higher liver stiffness (per 1% increase β =  - 0.12 ± 0.03, p = 0.002). Higher atrial pump strain (HR per 1% increase = 0.53 [95% confidence interval 0.22, 0.83], p = 0.002) and ventricular ejection fraction (HR per 1% increase = 0.90 [95% confidence interval 0.80, 0.98], p = 0.02) were associated with lower risk for the composite adverse outcome. Atrial function is impaired in Fontan patients and is associated with worse CI, EDP, exercise performance, liver stiffness, and a higher risk for adverse outcomes.