Three new thiosemicarbazones (TSCs) HL1-HL3 as triapine analogues bearing a redox-active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL1-HL3 with CuCl2·2H2O in anoxic methanol afforded three copper(II) complexes, namely, Cu(HL1)Cl2 (1), [Cu(L2)Cl] (2'), and Cu(HL3)Cl2 (3), in good yields. Solution speciation studies revealed that the metal-free ligands are stable as HL1-HL3 at pH 7.4, while being air-sensitive in the basic pH range. In dimethyl sulfoxide they exist as a mixture of E and Z isomers. A mechanism of the E/Z isomerization with an inversion at the nitrogen atom of the Schiff base imine bond is proposed. The monocationic complexes [Cu(L1-3)]+ are the most abundant species in aqueous solutions at pH 7.4. Electrochemical and spectroelectrochemical studies of 1, 2', and 3 confirmed their redox activity in both the cathodic and the anodic region of potentials. The one-electron reduction was identified as metal-centered by electron paramagnetic resonance spectroelectrochemistry. An electrochemical oxidation pointed out the ligand-centered oxidation, while chemical oxidations of HL1 and HL2 as well as 1 and 2' afforded several two-electron and four-electron oxidation products, which were isolated and comprehensively characterized. Complexes 1 and 2' showed an antiproliferative activity in Colo205 and Colo320 cancer cell lines with half-maximal inhibitory concentration values in the low micromolar concentration range, while 3 with the most closely related ligand to triapine displayed the best selectivity for cancer cells versus normal fibroblast cells (MRC-5). HL1 and 1 in the presence of 1,4-dithiothreitol are as potent inhibitors of mR2 ribonucleotide reductase as triapine.Skin wounds are usually accompanied by bacterial infections and inflammations, leading to delayed wound healing, which remain a great challenge in clinical treatment. Therefore, it is of great significance to develop wound dressings that inhibit bacterial infections to accelerate wound healing. Herein, we reported the fabrication of inclusion complex (a β-cyclodextrin covalent organic framework loaded with enrofloxacin and flunixin meglumine)-incorporated electrospun thermoplastic polyurethane fibers (named ENR-FM-COF-TPU) via electrospinning. The obtained ENR-FM-COF-TPU fibrous membrane exhibited excellent physicochemical and biological properties such as uniform and stable morphology, proper hydrophobicity, good water uptake capacity, and admirable biocompatibility, which showed perfect behavior as a wound dressing. In addition, the ENR-FM-COF-TPU membrane achieved a sustained drug release of enrofloxacin and flunixin meglumine and displayed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli with 99% inhibitory efficiency for 50 h. More importantly, the wound healing therapy effect was investigated using a full-thickness skin defect model of mice. It suggested that the ENR-FM-COF-TPU membrane could significantly accelerate and enhance wound healing through downregulating inflammatory cytokines (IL-1β and TNF-α) and increasing the expression of growth factors (VEGF and EGF). Due to its excellent properties, the ENR-FM-COF-TPU membrane may have promising potential in wound healing applications.Microbially induced calcite precipitation is a biomineralization process with numerous civil engineering and ground improvement applications. In replicate soil columns, the efficacy and microbial composition of soil bioaugmented with the ureolytic bacterium Sporosarcina pasteurii were compared to a biostimulation method that enriches native ureolytic soil bacteria in situ under conditions analogous to field implementation. The selective enrichment resulting from sequential stimulation treatments strongly selected for Firmicutes (>97%), with Sporosarcina and Lysinibacillus comprising 60 to 94% of high-throughput 16S rDNA sequences in each suspended community sample. Seven species of the former and two of the latter were present in greater than 10% abundance at different times, demonstrating unexpected within-genus diversity and robustness in the suspended phase of this highly selective environment. Based on longer 16S sequences, it was inferred that augmented S. pasteurii competed poorly with natural bacteria, decreasing to below detection after nine treatments, while the native microbial community was enriched to approximately that present in the stimulated columns. These analyses were corroborated by the observed convergence in bulk ureolytic rates and calcite contents between techniques. However, a 10-fold discrepancy between the observed cell density and an activity-based estimate indicates the attached community, uncharacterized despite efforts, substantially contributes to bulk behavior.As constructing hardware technology is widely regarded as an important step toward realizing brain-like computers and artificial intelligence systems, the development of artificial synaptic electronics that can simulate biological synaptic functions is an emerging research field. Among the various types of artificial synapses, synaptic transistors using an electrolyte as the gate electrode have been implemented as the high capacitance of the electrolyte increases the driving current and lowers operating voltages.  https://www.selleckchem.com/products/nik-smi1.html  Here, transistors using maltose-ascorbic acid as the proton-conducting electrolyte are proposed. A novel electrolyte composed of maltose and ascorbic acid, both of which are biocompatible, enables the migration of protons. This allows the channel conductance of the transistors to be modulated with the gate input pulse voltage, and fundamental synaptic functions including excitatory postsynaptic current, paired-pulse facilitation, long-term potentiation, and long-term depression can be successfully emulated. Furthermore, the maltose-ascorbic acid electrolyte (MAE)-gated synaptic transistors exhibit high mechanical endurance, with near-linear conductivity modulation and repeatability after 1000 bending cycles under a curvature radius of 5 mm. Benefitting from its excellent biodegradability and biocompatibility, the proposed MAE has potential applications in environmentally friendly, economical, and high-performance neuromorphic electronics, which can be further applied to dermal electronics and implantable electronics in the future.