ObjectiveTo investigate the efficacy and safety of pulmicort respulas immerse with nasopore as nasal packing after nasal endoscopic surgery on patients with chronic rhinosinusitis with nasal polyps. MethodThis single-blind, randomized study recruit 33 patients diagnosed as chronic rhinosinusitis with polyposis. All of them underwent bilateral endoscopic sinus surgery and randomized to receive pulmicort respulas immersed nasopore in one nasal cavity and saline immersed nasopore contralaterally. Both groups were followed up at 2, 4, 8, 12, 24 weeks after operation. Subjective （VAS score） and objective （Lund-Kennedy score） scores are collected at each time point from both sides of nasal cavity. ResultThere are 30 enrolled patients in the study completed the 24-week trial. Both the subjective and objective scores of two groups shows a significant reduction after the ESS operation. The VAS score of the two groups remains roughly unchanged during week 2 to week 24. A statistically significant difference of the Lund-Kennedy score can be detected between the groups from week 2 to week 24. Though the serum cortisol reduced （5.97±4.10） mmol/L vs （12.48±4.33） mmol/L after the surgery, neither group shows any clinical symptoms related with the hypothalamic-pituitary-adrenal axis suppression. ConclusionThis study demonstrated a significant improvement in postoperative healing in nasal cavities receiving pulmicort respulas immersed nasopore as nasal packing following ESS. This method of using budesonide is generally safe for patients with chronic rhinosinusitis with polyposis.ObjectiveThe objective is to investigate and compare the efficacy of intratympanic methylprednisolone or combination therapy as the salvage treatment for idiopathic sudden sensorineural hearing loss （ISSNHL）. MethodNinety patients with moderate-to-severe to profound SSNHL which were unresponsive to the conventional treatment were recruited. Among these 90 patients, 45 patients underwent intratympanic methylprednisolone therapy （IMT） alone and 45 patients underwent systemic dexamethasone+IMT（systemic steroids+IMT）. IMT was performed every other day, with a total of four times. The pure-tone audiogram （PTA） before and after IMT or systemic steroids+IMT was conducted. And for those with tinnitus or anxiety, tinnitus handicap inventory（THI）, visual analog scale （VAS） as well as Hamilton anxiety rating scale （HAMA） were performed before and after the treatment. ResultThe success rate was 31.1% with IMT and 51.1% with systemic steroids+IMT, and the difference was not significant between the two groups. The efficacy of patients with less than 30 days of onset was better than those with more than 30 days, and the difference was not significant, either. Both groups showed significant improvement in the scores of THI, VAS, and HAMA, but no significant difference was found between the two groups.  https://www.selleckchem.com/products/pf-07104091.html  ConclusionIntratympanic methylprednisolone is recommended as the salvage treatment for patients with moderate-to-severe to profound SSNHL which showed little efficacy after the conventional treatment. Prompt medication improves the therapeutic efficacy.ObjectiveTo describe the characteristics of nystagmus in patients with Light Cupulopathy and to investigate its therapeutic effect. MethodThe Supine roll test in our hospital's otology clinic showed persistent DCPN in 26 patients, who received Supine roll test, null-point position test, and prone-supine test. All patients were treated with barbecue maneuver. The immediate, short-term and long-term effects of treatment were investigated. ResultNull-point position on one side was present in 26 patients. The angles ranged from 15-45°, with an average of （26.34±8.78）°. Spontaneous nystagmus was observed in 30.8% （ 8/26 ） patients. The nystagmus was directed to the affected side in prone position and to the healthy side in supine position. Seventy-three percent of the patients had strong nystagmus and 26.9% had weak nystagmus in the Supine roll test. All patients received Barbecue maneuver, and the recovery rates were 0, 42.3% and 88.5% immediately, 1 week and 1 month after treatment respectively. There was a statistical difference in the recovery rate among immediate, one week and one month later （P less then 0.01）. ConclusionThe nystagmus performance of patients with persistent DCPN conforms to the light cupula hypothesis. The lesion side can be determined according to the null-point position and prone-supine test. The lesion side cannot be determined by the intensity of nystagmus in the Supine roll test in some cases. Repositioning maneuver is ineffective in treating light cupulopathy, but the disease is self-limited.ObjectiveTo study the clinical characteristics and common etiology of vocal cord leukoplakia, and explore the treatment principle. MethodOne hundred and fifty-seven patients with vocal cord leukoplakia were recruited in this study. They were assessed by routine laryngoscope, narrow band imaging （NBI）, stroboscope, reflux finding score （RFs） and reflux symptom index （RSI）, and given conservative treatment （smoking cessation, alcohol, acid suppression, sound cessation, etc.） and/or surgical treatment. ResultAmong 157 patients with leukoplakia of vocal cord, 109 （69.4%） had basically improved or cured after conservative treatment. Forty-eight cases underwent operation. The postoperative pathological diagnosis was mild dysplasia in 2 cases （1.3%）, moderate dysplasia in 15 cases （9.6%）, severe dysplasia or carcinoma in situ in 19 cases （12.1%）, and invasive carcinoma in 12 cases （7.6%）. ConclusionNBI and stroboscopic laryngoscopy showed that most of the leukoplakia of vocal cord was non-malignant in nature, which was not in accordance with the indication of operation. Conservative treatment is effective. Biopsy or operation was indicated in only a few patients. Moreover, most of the patients are accompanied by laryngopharyngeal reflux, and the treatment of acid suppression is effective.ObjectiveTo investigate the clinical characteristics, management and prognosis of laryngotracheal stenosis induced by relapsing polychondritis. MethodA retrospective analysis was performed of 11 patients with laryngotracheal stenosis induced by relapsing polychondritis. Stenosis was classified as Myer and Cotton grade Ⅱ in 4 patients, grade Ⅲ in 3 and grade Ⅳin 4. ResultLong-term T-tube implantation of thoracic tracheal stenosis was performed in 1 patient, and one patient who had underwent 2 dilations was decannulated, and the tube was successfully extubated in 9 cases who had underwent laryngotracheal reconstruction with sternohyoid myocutaneous flap or costal cartilage. ConclusionTreatment of laryngotracheal stenosis induced by relapsing polychondritis is challenging. If the surgical intervention was selected properly on an individual basis, favorable clinical outcome can be obtained.