Kratom is a habit-forming opioid-like substance with an acute toxidrome of various symptoms such as diaphoresis, dizziness, nausea, and vomiting. Chronic users require increasing dosages for the analgesic effects. Although kratom use dates back to the 1800s in Asia, kratom intoxication is still a novel (but increasing) toxidrome in the Western world.  https://www.selleckchem.com/products/ew-7197.html  Here, we present a novel case of acute toxicity from overdose in a kratom-naïve patient, taking place through recommendation by a family member who chronically takes this substance.
 
  We present the case of a 62-year-old woman arriving to the emergency department (ED) with a chief complaint of intractable vomiting after ingestion of kratom. After a day of yard work, she was in pain, secondary to her osteoporotic joints. She was recommended kratom from a family member, who stated he was using kratom to transition away from opioid dependence. She took two "scoops." She proceeded to have multiple episodes of vomiting at home. She came to the ED, where she requiredss the USA in the era of the opioid crisis. Further documentation of case reports and research is required to learn the associated risks of the use of this substance.
  The association with obesity of a common variant near the melanocortin-4 receptor (MC4R) gene (rs17782313) has been indicated in various studies. Adherence to dietary quality indices also have shown to have potential favorable effects on obesity-related health outcomes. However, no study has examined the interaction between rs17782313 and the Dietary Approach to Stop Hypertension (DASH) score and the Mediterranean Dietary Score (MDS) on cardio-metabolic risk factors and hypothalamic hormones. Therefore, the purpose of the current study was to examine whether adherence to these dietary quality indices modifies the association of the MC4R rs17782313 polymorphism with cardio-metabolic risk factors and hypothalamic hormones among obese adults.
 
  Two hundred eighty-eight healthy obese adults were recruited in this cross-sectional study. Diet quality indices, including DASH score and MDS, were calculated from a validated 147-item food frequency questionnaire (FFQ). MC4R s17782313 genotypes were determined by poly4R rs17782313 interacts with healthy dietary pattern (DASH score and MDS) to influence cardio-metabolic risk factors and hypothalamic hormones in obese individuals. Prospective cohort studies are needed to further assess these findings.
 MC4R rs17782313 interacts with healthy dietary pattern (DASH score and MDS) to influence cardio-metabolic risk factors and hypothalamic hormones in obese individuals. Prospective cohort studies are needed to further assess these findings.
  Despite the positive view about organ donation in our society, many people remain reluctant to donate. Identifying the perceived advantages and disadvantages and raising awareness about organ donation may help promote willingness for eligible people to become donors. Our aim was to determine the validity and reliability of the Organ Donation Decisional Balance Survey for the Turkish community in order to implement the transtheoretical model of behavior change and to emphasize the positive aspects of organ donation during the process of decision making.
 
  A total of 420 adults, including 304 women and 116 men, voluntarily participated in the study. A personal information form, now known as the Organ Donation Decisional Balance Survey, and the Compassion of Others' Lives scale were used to evaluate the participants. Confirmatory factor analysis was used to examine the factor structure of the questionnaire. All data were analyzed with confirmatory factor analysis using the Amos 16 programs.
 
  Analysis results showed that the fit index values of the survey were acceptable (P < .01). Factor loads of the survey for the advantages subdimension were between 0.53 and 0.78, and the factor loads for the disadvantages subdimension were from 0.46 to 0.75. Internal consistency of these 2 components resulted in an acceptable Cronbach alpha value. We also identified a positive correlation between the advantages score and the Compassion of Others' Lives scale score.
 
  This survey can guide those who prepare training programs on organ donation by highlighting positive thoughts and reducing negative judgments. The Turkish version of the Organ Donation Decisional Balance Survey is acceptable, valid, and reliable.
 This survey can guide those who prepare training programs on organ donation by highlighting positive thoughts and reducing negative judgments. The Turkish version of the Organ Donation Decisional Balance Survey is acceptable, valid, and reliable.Here, we describe the current situation regarding organ transplant in Uzbekistan. The legalization of paired-kidney exchange programs for donors with incompatible blood types in Uzbekistan will allow more opportunities for organ donation. The phased implementation of the transplant program with that of deceased-donor organ transplant can be carried out only with the involvement of public, cultural, and religious figures, and not only health professionals, to permanently shift the paradigm in the population.Australia is a multicultural society of just over 25 million people, with approximately 310 different ancestries, 300 languages, and 150 religions. This diversity suggests that Australia's people might hold a multiplicity of beliefs regarding organ donation. Research shows that most people in Australia have a strong, positive perception of organ donation; they believe that organ donation helps others and benefits society. However, the current rate of 21.6 donors per million population is below expectations and below the demand for organs needed for transplantation. This has led us to ask whether donation consent rates are differentiated by religious and cultural affiliation. We present a case study of New South Wales, Australia, to address this issue. New South Wales is the most populous state in Australia and is also religiously and culturally diverse. Donation consent data (2016-2019) by ethnicity and by religion show that donation consent rates have improved but not across all groups. Initiatives to increase awareness and support for organ and tissue donation among culturally and linguistically diverse and Aboriginal and Torres Strait Islander communities are discussed.