major histocompatibility complex locus in the genetic correlation between rheumatoid arthritis and schizophrenia, and suggests that either schizophrenia has an autoimmune basis and/or rheumatoid arthritis has an active neurological component.Microbial electrolysis cells (MECs) is one of the promising biohydrogen production technologies for which low-cost cathode materials are required and developed to propel the rapid development of MECs. Herein, the preparation of a low-cost Ce0.1 -Ni-Y composite is reported by using Y zeolite as carrier loaded with nickel (Ni) and cerium (Ce) as active components and its prominent electrochemical performance. The XPS analysis reveals that strong electronic interaction between Ni and Ce makes a great contribution to the electrochemical performance enhancement. The Ce0.1 -Ni-Y with a peak current density of 39.8 A⋅m-2 in LSV, Tafel slope of 40.81 mV⋅dec-1 , ECSA of 34.3 and hydrogen yield of 0.312±0.013 m3 ⋅m-3  d-1 are significantly superior to that of its parent Ni-Y counterpart and rival the performance of commercially Pt/C, which renders it a very promising hydrogen evolution catalyst for MECs.In Sterile Insect Technique (SIT) programs, massive numbers of insects are reared, sterilized, and released in the field to impede reproduction of pest populations. The domestication and rearing processes used to produce insects for SIT programs may have significant evolutionary impacts on life history and reproductive biology. We assessed the effects of domestication on sexual performance of laboratory reared Queensland fruit fly, Bactrocera tryoni, by comparing an old (49 generations) and a young colony (5 generations). We evaluated mating propensity, mating latency, copula duration, sperm transfer, and ability to induce sexual inhibition in mates. Overall, both males and females from the old colony had greater mating propensity than those from the young colony. Copula duration was longer when females were from the old colony. There was no evidence of sexual isolation between the colonies as males and females from the two colonies had similar propensity to mate with flies from either colony. Males from the old colony transferred more sperm regardless of which colony their mate was from. Finally, males from both colonies were similarly able to induce sexual inhibition in their mates and were also similarly able to secure copulations with already-mated females. Positive effects of domestication on sperm transfer, coupled with maintained ability to induce sexual inhibition in mates and to secure copulations with previously mated females, highlights that domestication may have little effect, or even positive effects, on some aspects of sexual performance that may advantage mass-reared B. tryoni in SIT programs.
  To describe 2 cases of boomslang (Dispholidus typus) envenomation in dogs, with thromboelastographic evaluation performed both pre- and postadministration of monovalent antivenom, and to contrast the clinical application of thromboelastography (TEG) with that of conventional coagulation testing in 1 of these cases for monitoring coagulation status in dogs suffering from such envenomation.
 
  Two dogs, a Weimeraner and a Dachshund, were referred, on separate occasions, for stabilization and treatment following observed boomslang envenomation. Initial physical examination revealed minor bleeding from the bite wound site in both dogs, along with mild swelling of the surrounding tissue. The Weimeraner also demonstrated bleeding from the gingival margin and had pale mucous membranes at time of presentation. Findings consistent with a diagnosis of disseminated intravascular coagulation (DIC) were noted on conventional coagulation testing. TEG tracings in both dogs revealed a hypocoagulable state preadministration of monovalent antivenom, followed by return to a normocoagulable state immediately postadministration, along with resolution of clinical bleeding. Both dogs were successfully discharged from the hospital, with no adverse reactions, either acute or delayed being noted.
 
  Boomslang envenomation (hemotoxic snake venom) in dogs is rare, with currently only 3 cases in the literature. Herein, we document a further 2 cases and contrast changes on TEG with that noted on a routine hemostatic testing profile in 1 of these cases, to assess overall coagulation status both pre- and postadministration of antivenom.
 Boomslang envenomation (hemotoxic snake venom) in dogs is rare, with currently only 3 cases in the literature. Herein, we document a further 2 cases and contrast changes on TEG with that noted on a routine hemostatic testing profile in 1 of these cases, to assess overall coagulation status both pre- and postadministration of antivenom.Cuticular wax is a natural barrier on terrestrial plant organs, which protects plants from damages caused by a variety of stresses. Here, we report the identification and functional characterization of a cuticular-wax-related gene, Zea mays L. SEMI-ROLLED LEAF 5 (ZmSRL5).  https://www.selleckchem.com/products/DMXAA(ASA404).html  The loss-of-function mutant srl5, which was created by a 3,745 bp insertion in the first intron that led to the premature transcript, exhibited abnormal wax crystal morphology and distribution, which, in turn, caused the pleiotropic phenotypes including increased chlorophyll leaching and water loss rate, decreased leaf temperature, sensitivity to drought, as well as semi-rolled mature leaves. However, total wax amounts showed no significant difference between wild type and semi-rolled leaf5 (srl5) mutant. The phenotype of srl5 was confirmed through the generation of two allelic mutants using CRISPR/Cas9. ZmSRL5 encodes a CASPARIAN-STRIP-MEMBRANE-DOMAIN-LIKE (CASPL) protein located in plasma membrane, and highly expressed in developing leaves. Further analysis showed that the expressions of the most wax related genes were not affected or slightly altered in srl5. This study, thus, primarily uncovers that ZmSRL5 is required for the structure formation of the cuticular wax and could increase the drought tolerance by maintaining the proper cuticular wax structure in maize.
  To describe and explore the relationship between baseline anxiety, depression and symptom experience in children and youth assessed at a concussion clinic.
 
  A retrospective chart review of concussed children and youth referred to a pediatric teaching hospital concussion clinic over a 15-month period was completed. Kutcher Adolescent Depression Scale (KAD-6), General Anxiety Disorder Scale (GAD-7), and the Post-Concussion Symptom Inventory (PCSI) scores were extracted.
 
  A total of 155 patients were included. The most common symptoms (PCSI) at baseline were headache, fatigue, and feelings of head pressure. Symptoms were rated as mild to moderate in intensity. Overall, mean depression and anxiety scores were low. The mean anxiety scores, as measured by the GAD-7 (n = 108), was 7.4 (range, 0-24). The mean depression score, as measured by the KAD-6 (n = 94), was 4.7 (range, 0-18). A statistically significant, moderate positive correlation between PCSI scores with KAD-6 scores for male (r = .64, p < .001) and female (r = .