1, AK148935, uc029sdr.1, ENSMUST00000132340, AK030988, uc007mds.1, ENSMUST00000180519) as well as 282 interacted and altered mRNAs, and were connected by 713 edges. GO and KEGG analyses suggested that altered mRNAs, as well as those lncRNA-interacted mRNAs were enriched in immune system process and chemokine signaling pathway. Thus, lncRNAs are significantly altered in this mouse model of CNV and are involved in immunological regulation, suggesting that lncRNAs may play a critical role in the pathogenesis of CNV. Thus, dysregulated lncRNAs and their target genes might be promising therapeutic targets to suppress CNV in AMD. © The author(s).BACKGROUND Colorectal cancer (CRC) is the third commonly diagnosed cancer worldwide. Recurrence of CRC (Re) and onset of a second primary malignancy (SPM) are important indicators in treating CRC, but it is often difficult to predict the onset of a SPM. Therefore, we used mechanical learning to identify risk factors that affect Re and SPM. PATIENT AND METHODS CRC patients with cancer registry database at three medical centers were identified. All patients were classified based on Re or no recurrence (NRe) as well as SPM or no SPM (NSPM). Two classifiers, namely A Library for Support Vector Machines (LIBSVM) and Reduced Error Pruning Tree (REPTree), were applied to analyze the relationship between clinical features and Re and/or SPM category by constructing optimized models. RESULTS When Re and SPM were evaluated separately, the accuracy of LIBSVM was 0.878 and that of REPTree was 0.622. When Re and SPM were evaluated in combination, the precision of models for SPM+Re, NSPM+Re, SPM+NRe, and NSPM+NRe was 0.878, 0.662, 0.774, and 0.778, respectively. CONCLUSIONS Machine learning can be used to rank factors affecting tumor Re and SPM. In clinical practice, routine checkups are necessary to ensure early detection of new tumors. The success of prediction and early detection may be enhanced in the future by applying "big data" analysis methods such as machine learning. © The author(s).BACKGROUND During the 19th and early 20th centuries, large waves of international immigrants, often heterogeneous in terms of age and sex structure, arrived in the United States. Within a relatively short time, many of these immigrants were assimilated. While prior studies have identified an impact of the marriage squeeze on intermarriage, the role of gender is less known. METHODS We use data from the 1930 census to examine the role played by variation in the sex ratios of the six largest immigrant groups at the beginning of the 20th century on marital outcomes by sex. RESULTS Our analyses show that the probability of marrying outside one's ethnic group in this period is strongly tied to local ethnic sex ratios. Marital outcomes are affected for both sexes, but sex ratios are found to be more influential on males marrying out of their ethnic group. While a surplus of one's own sex increases the probability of exogamy for males, it is likely to increase the probability of being single for females. CONTRIBUTION Our findings highlight the importance of ethnic sex ratios in local marriage markets at a critical juncture of American immigration and its consequences. We focus on an understudied aspect of this process gender differences in the association between sex ratios and marital assimilation. We show that marital decisions differed by sex and that the high levels of intermarriage in this period are more likely to be explained by unbalanced sex ratios for males than for females.Comprehensive plans provide an overall vision for a city's land use and development and influence community health conditions. As part of a community-engaged research project, a Healthy Living and Active Design Scorecard was applied to the comprehensive plan of League City, Texas, to identify health-promoting design and planning strategies.  https://www.selleckchem.com/products/lys05.html  Although the plan scored similarly to published examples, several areas of improvement aligned with priorities from a community health assessment were identified, including improving public transportation and access to exercise and recreation. Future revisions of the plans and neighbourhood scaled designs targeting these issues could improve the health of the community.Background Terrestrial Caenogastropoda form an important but threatened component of the Borneo tropical rainforest malacofauna, where the group is nearly as rich in species as the Stylommatophora. They are, however, more sensitive to drought, temperature extremes and forest degradation. New information On a field course at Kuala Belalong Field Studies Centre in Brunei Darussalam (Borneo), a new caenogastropod species, belonging to the genus Craspedotropis, was discovered by the course participants. The participants decided to name the species Craspedotropis gretathunbergae n. sp., in honour of the climate change activist Greta Thunberg, as caenogastropod land snails, such as this species, are likely to suffer because of climate change. Menno Schilthuizen, Jonathan P Lim, Anthonie D. P. van Peursen, Massimiliano Alfano, Awang Bikas Jenging, Daniele Cicuzza, Alexandre Escoubas, Pierre Escoubas, Ulmar Grafe, Jamil Ja, Peter Koomen, Aleks Krotoski, Denise Lavezzari, Laura Lim, Rudie Maarschall, Ferry Slik, Derek Steele, Dennis Teck Wah Ting, Ine van Zeeland, Iva Njunjić.The orchid tribe Tropidieae comprises three genera, Tropidia, Corymborkis and Kalimantanorchis. There are three fully mycoheterotrophic species within Tropidieae Tropidia saprophytica, T. connata and Kalimantanorchis nagamasui. A previous phylogenetic study of K. nagamasui, based only on plastid matK data, placed K. nagamasui outside the clade of Tropidia and Corymborkis without support. In this study, we performed phylogenetic analyses using a nuclear ribosomal DNA spacer (ITS1-5.8S-ITS2), a low-copy nuclear coding gene (Xdh) and a mitochondrial intron (nad1b-c intron) to study the phylogenetic relationships within Tropidieae. We included six photosynthetic and all three fully mycoheterotrophic Tropidieae species. The resulting phylogenetic trees placed these fully mycoheterotrophic species inside the Tropidia clade with high support. In our trees, these three species do not form a monophyletic group together, because the photosynthetic T. graminea is nested amongst them. Our results also suggest that the loss of photosynthetic ability occurred at least twice in Tropidia.