However, preliminary efficacy studies in the same animal model found no decrease in bacterial load upon treatment with Pt1 and Pt2. Serum exchange studies suggest that these compounds exhibit high serum binding which reduces their bioavailability in vivo, mandating alternative administration routes such as e. g. topical application.Printed electronics are expected to facilitate the widespread distributed wearable electronics in the era of the Internet of things. However, developing cheap and stable electrode inks remains a significant challenge in the printed electronics industry and academic community. Here, overcoming the weak hydrophilicity of polyaniline, a low-cost, easy-fabricating, and air-stable conducting polymer (CP) ink is devised through a facile assemble-disperse strategy delivering a high conductivity in the order of 10-2 S cm-1 along with a remarkable specific capacitance of 386.9 F g-1 at 0.5 A g-1 (dehydrated state). The additive-free CP ink is directly employed to print wearable micro-supercapacitors (MSCs) via the spray-coating method, which deliver a high areal capacitance (96.6 mF cm-2 ) and volumetric capacitance (26.0 F cm-3 ), outperforming most state-of-the-art CP-based supercapacitors. This work paves a new approach for achieving scalable MSCs, thus rendering a cost-effective, environmentally friendly, and pervasive energy solution for next-generation distributed electronics.The NanoString GeoMx digital spatial profiling is a new multiplexed platform that quantifies the abundance of tumor- and immune-related proteins in a spatially resolved manner. We performed DSP for the simultaneous assessment of 52 analytes within spatially resolved tissue compartments defined by pan-cytokeratin expression. We compared protein targets between 94 African American/Black and 65 European American/White cases, tumor and stromal tissue compartments, estrogen receptor alpha (ER)-positive and ER-negative cases, and explored potential biomarkers of survival. Of 33 analytes with robust signal for analysis, results were highly replicable. For a subset of markers, correlative analyses between DSP analytes and traditional immunohistochemistry scores revealed moderate to very strong associations between the two platforms. Similarly, DSP analytes and gene expression scores were concordant for 21 of 25 markers with overlap between the two datasets. Several analytes varied by ER status, and across the 25 immune markers surveyed, 14 had a significant inverse association with ER expression. B7 homolog 3 (B7-H3; encoded by CD276) was the only analyte to show a significant difference by race, being lower in both the tumor and stromal compartments in Black women. DSP markers that were associated with survival included CD8, CD25, CD56, CD127, EpCAM, ER, Ki-67, and STING. We conclude that DSP is an efficient tool for screening tumor- and immune-related markers in a simultaneous fashion and yields results that are concordant with established immune profiling assays. DSP immune analytes were inversely associated with ER expression, in agreement with a substantial body of previous work that documents higher immune infiltration in ER-negative breast cancers. This technology revealed that scores of the B7-H3 protein were significantly lower in breast cancers from Black women compared with White women, an intriguing finding that requires replication in independent and racially diverse female populations.The poor stability, in particular with respect to temperature, moisture, and light exposure, remains a ubiquitous impediment virtually for metal halide perovskite materials and devices in their future practical application. Herein, from the perspective of precursor solution chemistry, ionic liquid solvent methylammonium acetate (MAAc) is introduced to prepare high-quality MAPbBr3 perovskite thin films in a one-step air-processing process without anti-solvent treatment. Due to formation of pinhole-free, uniform, and compact MAPbBr3 perovskite film, excellent amplified spontaneous emission (ASE) with high emission efficiency and low threshold is obtained under nanosecond laser. Furthermore, the prepared MAPbBr3 perovskite exhibits excellent two-photon induced ASE with a low threshold of 100 µJ cm-2 under 800 nm femtosecond laser excitation. More importantly, in comparison with the traditional MAPbBr3 films prepared with N,N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), the MAPbBr3 film prepared with MAAc shows excellent optical stability no signs of degradation under more than 2 h pulsed laser excitation, stable ASE emission spectra under the humidity of 95% and ASE spectra can be stimulated when films are kept in air for more than 6000 h without encapsulation.Future applications of conjugated polymer particles (CPP) in medicine, organic photonics, and optoelectronics greatly depend on high performance and precisely adjustable optical properties of the particles. To meet these criteria, current particle systems often combine conjugated polymers with inorganic particles in core-shell geometries, extending the possible optical characteristics of CPP. However, current conjugated polymer particles are restricted to a single polymer phase composed of a distinct polymer or a polymer blend. Here, a synthetic toolbox is presented that enables the synthesis of monodisperse core-shell and core-shell-shell particles, which consist entirely of conjugated polymers but of different types in the core and the shells.  https://www.selleckchem.com/products/ipi-145-ink1197.html  Seeded and fed-batch dispersion polymerizations based on Suzuki-Miyaura-type cross-coupling are investigated. The different approaches allow accurate control over the created interface between the conjugated polymer phases and thus also over the energy transfer phenomena between them. This approach opens up completely new synthetic freedom for fine tuning of the optical properties of CPP, enabling, for example, the synthesis of individual white light-emitting particles.In this study, we compared the responses of two different types of zwitterionic polymers (ZPs), polyvinylimidzole sulfobetaine (poly(SBVI)) and polymethacrylate sulfobetaine (poly(SBMA)) to Hofmeister anions. Although the anions of the two ZPs were the same as the sulfonate anions and only the types of their cations were different from each other, the aggregation behavior of each in the salt aqueous solution was remarkably different. Consequently, poly(SBVI) exhibited both salting-in and salting-out effects depending on the type and concentration of salt, while poly(SBMA) only exhibited the anti-polyelectrolyte effect. The results of this study provide a deeper understanding of the behavior of zwitterionic polymers in salt solutions and will greatly expand their applications.