The aim To study the peculiarities of bone mineral density in the Ukrainian population of women of different reproductive age with systemic lupus erythematosus and to evaluate its connection with traditional and specific (typical for systemic lupus erythematosus) risk factors.
 
  Materials and methods A total of 91 women with systemic lupus erythematosus and 29 healthy individuals were examined. Along with the clinical study of the activity and severity of the disease, the serum levels of interleukin-6 were determined by the enzyme immunoassay. The peculiarities of bone mineral density were studied using dual-energy X-ray absorptiometry. The presence of fractures was evaluated by the X-ray method.
 
  Results Patients with systemic lupus erythematosus frequently suffer from reduced bone mineral density. Reduced bone mineral density and the appearance of fragility fractures are associated with patients' age, disease duration, damage index, inflammatory activity, and cumulative dose of glucocorticoids.
 
  Conclusions Progressive reduced bone mineral density in patients with systemic lupus erythematosus occurs not only during the aging process of a woman, but is also associatedwith a number of systemic lupus erythematosus - related osteoporosis risk factors.
 Conclusions Progressive reduced bone mineral density in patients with systemic lupus erythematosus occurs not only during the aging process of a woman, but is also associatedwith a number of systemic lupus erythematosus - related osteoporosis risk factors.
  The aim Is to investigate the dynamics of the morphofunctional development and physical health of students who were engaged in strength sports while studying at university.
 
  Materials and methods The study involved 360 male students of different faculties between the ages of 17 and 20. Two groups of students were formed experimental and control groups. The EG students (n=40) were engaged in strength sports (powerlifting, athletics, Crossfit); the CG students (n=320) were training according to the current program of physical education. The study of the morphofunctional development of students was carried out taking account of the indicators of body length, body weight, handgrip test, heart rate, blood pressure, and vital capacity. The level of students' health was examined according to the methodology of the assessment of the physical health level by G. L.  https://www.selleckchem.com/products/lificiguat-yc-1.html  Apanasenko.
 
  Results It was established that strength sports at university affect physical development, functional abilities of the major systems of an organism, and the health state of future doctors in a more efficient way than the current program of physical education. It was found that the influence on the indicators of handgrip test, vital capacity, and heart rate of the EG students was the most prominent positive effect of sports. The evaluation of the calculated indexes (power index, life index) and the level of physical health confirmed this trend.
 
  Conclusions The conducted research asserts the necessity of introducing the sports-oriented form of the physical training organization at the medical higher education institutions of Ukraine to strengthen the students' health and to maintain the efficiency of the future doctors' professional activity.
 Conclusions The conducted research asserts the necessity of introducing the sports-oriented form of the physical training organization at the medical higher education institutions of Ukraine to strengthen the students' health and to maintain the efficiency of the future doctors' professional activity.
  The aim To determine the peculiarities of the morphometric parameters of suprahyoid region of the human prefetuses.
 
  Materials and methods Thirty specimens of human prefetuses of 14.0-80.0 mm parietococcygeal length (PCL) (7-12 weeks of IUD) were studied using a complex of modern methods of morphological research.
 
  Results On the basis of obtained digital indicators of the main morphometric parameters of human SHR in the dynamics of the prenatal period of IUD the critical periods of development of the region were clarified and mathematical functions that describe the normal course of organogenesis of SHR were created, which can be useful for creating diagnostic algorithms for the norm when carrying out prenatal diagnostics and monitoring the state of the fetus. It has been established that the 9-10th week of IUD is a critical period in the development of SHR, since during this time, intensive growth processes occur, which are manifested by a sharp change in the size of the organ, and this can lead to the h week of IUD is a critical period in the development of SHR, since during this time, intensive growth processes occur, which are manifested by a sharp change in the size of the mandible.
  The aim To study the regulation of acid-base balance and blood acid - renal excretory function in patients with COPD.
 
  Materials and methods We examined 82 people, suggests that even during the most severe stages of COPD. Group 1 included 56 patients with COPD, group C. The average age was 60.54 + 2.04 years old, including 24 men and 32 women. The second group included 16 patients with COPD, group B, whose average age was 55.37 + 3.21 years old, including 7 men and 9 women. The third group included 10 healthy individuals, with an average age of 34.30 + 2.21 years, including 6 men and 4 women. Respiration function was evaluated on the basis of the forced expiratory curve recorded on a Spirolab II MIR S / N computer spirograph. The following indicators were evaluated forced vital capacity (FVC), forced expiratory volume (FEV1) and FEV1 / FVC ratio.
 
  Results For all patients with COPD there is a characteristic presence of acidosis (pH in patients with COPD group B - 7,34 ± 0,01, in patients with COPD group C - 7,31 ± 0,07). For patients with COPD group C there are pronounced respiratory disorders (pCO2 - 48,25 + 1,14 mm Hg, p02 - 28.07 +1.37 mm Hg). For patients with COPD group B characteristic metabolic disorders (BE--3,71 + 0,57), which increase as the disease progresses. For patients with COPD group C this figure is equal to 7.62 + 0.49. Thus, the analysis of indicators indicates the presence for all patients of mixed (respiratory and metabolic) acidosis, which increases as the chronic obstructive pulmonary disease progresses.
 
  Conclusions There is activation of acid - renal excretory function and the inclusion of renal mechanisms in the regulation of acid-base balance.
 Conclusions There is activation of acid - renal excretory function and the inclusion of renal mechanisms in the regulation of acid-base balance.