Radiation monotherapy effectively relieves symptoms of esophageal cancer. Many studies have reported relief from dysphagia with this treatment; however, the degree of the dysphagia is subjective. On the other hand, the length of outpatient management is objective.  https://www.selleckchem.com/products/cnqx.html  In this study, we investigated how radiation monotherapy can contribute to helping elderly patients with esophageal cancer remain as outpatients.
 
  Between January 2010 and December 2017, we followed 42 patients aged >75 years who underwent radiation monotherapy for esophageal carcinoma. Of these patients, 36 were included in the study. We retrospectively collected data on the patients' characteristics, tumor extension around the circumference of the esophagus, medical procedures, prognosis, cause of death, and outpatient management period. We also analyzed the relationships between the outpatient management period, the clinical stage, and the circumferential extension of the tumor.
 
  Of the 36 patients (26 males, 10 females), 27 were treated using doses of 60 or 66 Gy, and 9 received 40 or 50 Gy. The median survival period of the patients who died during the study was 14 months, and their median period of outpatient management was 9 months. Eight of the 12 patients with tumors extending across four-fifths or the entire circumference of the esophagus required medical intervention to administer nutrition. There were no significant differences in the period of outpatient management among the patients who died during the study in terms of clinical stage and horizontal location.
 
  Radiation monotherapy may facilitate outpatient management; however, patients with tumors extending all or most of the circumference of the esophagus required an additional medical procedure.
 Radiation monotherapy may facilitate outpatient management; however, patients with tumors extending all or most of the circumference of the esophagus required an additional medical procedure.
  Coronavirus disease 2019 (COVID-19) is a global public health event without specific therapeutic agents till now. We aim to determine if high dose intravenous vitamin C (HDIVC) was effective for COVID-19 patients in severe condition.
 
  COVID-19 patients admitted in Shanghai Public Health Clinical Center from January 22, 2020 to April 11, 2020 were retrospectively scrolled. The enrolled patients were those with confirmed diagnosis of severe or critical COVID-19 pneumonia, who received HDIVC within 24 hours after disease aggravation. Main clinical outcomes obtained from 3-5 days (day 3) and 7-10 days (day 7) after HDIVC were compared to the ones just before (day 0) HDIVC.
 
  Totally, twelve patients were enrolled including six severe [age of mean, 56; interquartile range (IQR), 32-65 years, 3 men] and six critical (age of mean, 63; IQR, 60-82 years, 4 men) patients. The dosage of vitamin C [median (IQR), mg/kg (body weight)/day] were [162.7 (71.1-328.6)] for severe and [178.6 (133.3-350.6)] for critical patienl has been retrospectively registered in Chinese Clinical Trail Registry (ChiCTR2000032716) on May 8, 2020. http//www.chictr.org.cn/showproj.aspx?proj=53389.
  Discoid meniscus is an abnormal meniscus of the knee joint. This study aimed to analyze the clinical efficacy of arthroscopy in the treatment of discoid meniscus injury, and determine the related risk factors for postoperative pain.
 
  A total of 80 patients with a discoid meniscus injury who were diagnosed and treated in our hospital from May 2017 to May 2018 were selected. According to the different surgical methods, they were divided into the study group (treated with meniscus plasty) or the control group (treated with subtotal meniscectomy). Knee joint motion and knee joint function were measured at 2, 6 and 12 weeks post-surgery. Knee joint function was measured using the Lysholm Knee Scoring Scale to determine clinical efficacy. Patients with an excellent and good rating were included in the painless group, and patients with an average and poor rating were included in the pain group. The risk factors for postoperative pain were analyzed using multivariate logistic regression.
 
  Knee joint motion in then and control measures should be taken to improve postoperative pain and promote the recovery of knee joint function.
 Arthroscopy demonstrated efficacy for the treatment of patients with a discoid meniscus injury. Age, duration of preoperative symptoms, articular cartilage injury, postoperative cold compress and postoperative weight-bearing time were independent risk factors that affected postoperative pain after arthroscopic surgery. For high-risk patients, effective prevention and control measures should be taken to improve postoperative pain and promote the recovery of knee joint function.
  Chronic obstructive pulmonary disease (COPD) is a major burden and a leading cause of death worldwide. Comorbidities such as gastroesophageal reflux, arrhythmia, musculoskeletal disorders and cancer affect the quality of life of COPD patients. Psychological factors, such as disease perception, active coping with the disease, anxiety and depression may also affect daily activities and quality of life.
 
  This cross-sectional study surveyed 86 patients from rural Sichuan in China who had grade 1-3 COPD based on the Global Initiative for Chronic Obstructive Lung Disease scale in order to clarify the relationship of psychological factors with daily activities and quality of life. Respondents filled out the following questionnaires the Brief Illness Perception Questionnaire (as an assessment of disease perception), Utrecht Proactive Coping Competence Questionnaire (active coping), the Hospital Anxiety Depression Scale (anxiety and depression), the Modified Medical Research Council Scale (dyspnea), the Functional Performance Inventory-Short Form (daily activities) and the Clinical COPD Questionnaire (quality of life). Linear regression was used to explore potential relationship of these psychological factors with daily activities and quality of life.
 
  Active coping (β=-0.696, P<0.001) was related to less restricted daily activities, and better quality of life was associated with better disease perception (β=0.680, P<0.001) and lower anxiety (β=0.479, P<0.001).
 
  These results suggest that appropriate psychological interventions may benefit COPD patients, which deserves further investigation.
 These results suggest that appropriate psychological interventions may benefit COPD patients, which deserves further investigation.