The Artery of Percheron (AOP) is an uncommon anatomic variant that provides arterial supply to the paramedian region of the thalami and bilaterally to the rostral part of the midbrain; it is a solitary arterial trunk that branches from a proximal segment of the posterior cerebral artery (PCA). Although AOP infarction results in a characteristic pattern of ischemia, namely bilateral paramedian thalamic infarct with or without midbrain involvement, it may cause diagnostic difficulties due to the variety of its clinical presentations and wide differentials, as well as its small diameter and the difficulty of obtaining visualization through diagnostic imaging. Early neuroimaging of AOP infarction and correct diagnosis are mandatory for early initiation of the appropriate treatment and better patient outcomes. This study discusses the imaging patterns and imaging differentials of AOP infarction and its clinical presentation. A 55-year-old man presented to the emergency department unconscious with Glasgow Coma Scal day, with mild neurologic deficit. AOP must be considered whenever paramedian thalamic infarction is noted in neuroimaging. The difficulty in visualizing the AOP using diagnostic imaging is due to its small diameter, leading to the limited abilities of MRA and CTA to diagnose AOP infarction. An absence of evidence of AOP infarction in MRA or even CTA does not exclude its diagnosis. Good knowledge of the imaging characteristics of AOP infarction will help in early diagnosis and the achievement of good patient outcomes.
  Oliceridine, an investigational IV opioid, is a first-in-class G-protein selective agonist at the 
  -opioid receptor. The G-protein selectivity results in potent analgesia with less recruitment of 
  -arrestin, a signaling pathway associated with opioid-related adverse events (ORAEs). In randomized controlled studies in both hard and soft tissue models yielding surgical pain, oliceridine provided effective analgesia with a potential for an improved safety and tolerability profile at equianalgesic doses to morphine. The phase 3, open-label, single-arm, multicenter ATHENA trial demonstrated the safety, tolerability, and effectiveness of oliceridine in moderate to severe acute pain in a broad range of patients undergoing surgery or with painful medical conditions warranting use of an IV opioid.  https://www.selleckchem.com/products/lotiglipron.html  This retrospective, observational chart review study compared respiratory depression events associated with oliceridine administration as found in the ATHENA trial to a control cohort treated with conventional opioids.
 
 the oliceridine cohort compared to the CO cohort (8.0% vs. 30.7%; odds ratio 0.139) (95% confidence interval [CI] 0.09-0.22; 
  < 0.0001). Likewise, the incidence of OIRD was lower among high-risk patients in the oliceridine cohort (9.1% vs. 34.7%; odds ratio 0.136) (95% CI [0.09-0.22]; 
  < 0.0001) compared to the CO cohort.
 
  In this retrospective chart review study, patients receiving IV oliceridine for moderate to severe acute pain demonstrated a lower incidence of treatment emergent OIRD compared to patients who were treated with IV morphine either alone or with concomitant administration of other opioids.
 In this retrospective chart review study, patients receiving IV oliceridine for moderate to severe acute pain demonstrated a lower incidence of treatment emergent OIRD compared to patients who were treated with IV morphine either alone or with concomitant administration of other opioids.This study investigated spatial distribution and asymmetry of surface electromyography on lumbar muscles during a sustained contraction in soldiers with and without chronic low back pain. Twenty healthy soldiers and twenty chronic low back pain (CLBP) soldiers had performed the Sorensen test with a duration of 60 seconds. The corresponding muscle fatigue, spatial distribution, and the asymmetry of muscle activity over bilateral paraspinal lumbar regions were measured by the high-density surface electromyography (HDsEMG). The paired and independent samples t-tests were performed to compare the degree of muscle fatigue and asymmetry. The repeated-measures analyses of variance (ANOVA) were used to compare spatial distribution between groups and muscle fatigue. The baseline characteristics of soldiers between groups were comparable. CLBP soldiers had significantly less muscle fatigue on both sides of erector spinae compared to healthy ones. The spatial distribution was significantly associated with the group factor but independent of muscle fatigue. In addition, the asymmetry of erector spinae activity in the CLBP soldiers was significantly higher than the healthy one. In conclusion, uneven spatial distribution and asymmetry of lumbar muscle activity play significant roles in CLBP patients. The HDsEMG could be used as an objective method in distinguishing the function of the erector spinae between healthy individuals and CLBP patients during 1 min sustained contraction.Riparian communities in the Habsburg monarchy experienced perennial flooding with tragedy often eliciting heroics and generosity. What made these empathetic responses even more admirable was their juxtaposition with the antipathy that nationalist groups expressed in the political realm in the monarchy's final decades. Studying government and public responses to flooding in the nineteenth century demonstrates the critical link between empire and environment which forged transnational communities through floods of adversity, charity and cooperation. As this paper is part of a special issue, Water History in the time of COVID-19, it has undergone modified peer review.
  Historically traditional Chinese medicine (TCM) has been used as treatment during epidemics. During the recent COVID-19 pandemic patients evidence suggests that the use of TCM has provided health benefits and has been successfully used to control the spread of the disease in China. The aim of this study was to systematically explore the TCM formulae which have been used for the prevention and treatment of pneumonia or 'pestilence' to investigate their compatibility with the Chinese materia medica (CMM) and understand their potential mechanisms in the treatment of COVID-19.
 
  Frequency analysis was performed to identify high-frequency CMM and CMM groups. Association rules analysis was applied to investigate the compatibility law of CMMs and generate the commonly used CMM groups.
 
  A total of 173 prescriptions were collected. The frequency analysis showed that seven out of ten high-frequency CMMs overlapped with 
  (LHQWC), and five high-frequency pair-CMMs and four triple-CMMs were included in LHQWC, respectively.