This study evaluated the earthquake warning system for high-speed trains using onboard accelerometers instead of expensive seismometers. Onboard accelerometers measure the train data additional to the earthquake acceleration. The measured earthquake acceleration could also be modified by railroad-supporting bridges. To develop the data analysis system, the virtual onboard data sets are synthesized using the train acceleration data and earthquake data. Not only the earthquake acceleration data but also the earthquake responses of bridges are used for the virtual onboard data synthesis. For the analysis of synthesized data, the short-time Fourier Transform (STFT), the wavelet transform (WT), and Wigner-Ville Distribution (WVD) methods have been compared. Results show that WVD provides the best detection performance while the computational costs are large.A comprehensive understanding of the behaviour of Glycosaminoglycans (GAGs) combined with imaging or therapeutic agents can be a key factor for the rational design of drug delivery and diagnostic systems. In this work, physical and thermodynamic phenomena arising from the complex interplay between GAGs and contrast agents for Magnetic Resonance Imaging (MRI) have been explored. Being an excellent candidate for drug delivery and diagnostic systems, Hyaluronic acid (HA) (0.1 to 0.7%w/v) has been chosen as a GAG model, and Gd-DTPA (0.01 to 0.2 mM) as a relevant MRI contrast agent. HA samples crosslinked with divinyl sulfone (DVS) have also been investigated. Water Diffusion and Isothermal Titration Calorimetry studies demonstrated that the interaction between HA and Gd-DTPA can form hydrogen bonds and coordinate water molecules, which plays a leading role in determining both the polymer conformation and the relaxometric properties of the contrast agent. This interaction can be modulated by changing the GAG/contrast agent molar ratio and by acting on the organization of the polymer network. The fine control over the combination of GAGs and imaging agents could represent an enormous advantage in formulating novel multifunctional diagnostic probes paving the way for precision nanomedicine tools.High-density lipoprotein (HDL) is well-known for its cardioprotective effects, as it possesses anti-inflammatory, anti-oxidative, anti-thrombotic, and cytoprotective properties. Traditionally, studies and therapeutic approaches have focused on raising HDL cholesterol levels. Recently, it became evident that, not HDL cholesterol, but HDL composition and functionality, is probably a more fruitful target. In disorders, such as chronic kidney disease or cardiovascular diseases, it has been observed that HDL is modified and becomes dysfunctional. There are different modification that can occur, such as serum amyloid, an enrichment and oxidation, carbamylation, and glycation of key proteins. Additionally, the composition of HDL can be affected by changes to enzymes such as cholesterol ester transfer protein (CETP), lecithin-cholesterol acyltransferase (LCAT), and phospholipid transfer protein (PLTP) or by modification to other important components. This review will highlight some main modifications to HDL and discuss whether these modifications are purely a consequential result of pathology or are actually involved in the pathology itself and have a causal role. Therefore, HDL composition may present a molecular target for the amelioration of certain diseases, but more information is needed to determine to what extent HDL modifications play a causal role in disease development.Water management is a critical mission required to protect the water resources that is essential in diverse industrial applications. Amongst a variety of parameters such as level (or depth), temperature, conductivity, turbidity, and pH, the water level is the most fundamental one that needs to be monitored on a real-time basis for securing the water management system. This paper presents an overview of water level monitoring technologies based on optical fiber sensor (OFS) networks. Firstly, we introduce and compare the passive distributed and quasi-distributed (discrete) sensor networks with the recent achievements summarized. The performance (i.e., sensing range and resolution) of the OFS networks can be enhanced through diverse multiplexing techniques based on wavelength, time, coherence, space, etc. Especially, the dense wavelength division multiplexing (DWDM)-based sensor network provides remote sensing (where its reach can be extended to >40 km) with high scalability in terms of the channel number that determines the spatial resolution. We review the operation principle and characteristics of the DWDM-based OFS network with full theoretical and experimental analysis being provided. Furthermore, the key system functions and considerations (such as the link protection from physical damages, self-referencing, management of sensing units, and so on) are discussed that could be a guideline on the design process of the passive OFS network.Palmitoylethanolamide (PEA) belongs to the class of N-acylethanolamine and is an endogenous lipid potentially useful in a wide range of therapeutic areas; products containing PEA are licensed for use in humans as a nutraceutical, a food supplement, or food for medical purposes for its analgesic and anti-inflammatory properties demonstrating efficacy and tolerability.  https://www.selleckchem.com/products/Perifosine.html  However, the exogenously administered PEA is rapidly inactivated; in this process, fatty acid amide hydrolase (FAAH) plays a key role both in hepatic metabolism and in intracellular degradation. So, the aim of the present study was the design and synthesis of PEA analogues that are more resistant to FAAH-mediated hydrolysis. A small library of PEA analogues was designed and tested by molecular docking and density functional theory calculations to find the more stable analogue. The computational investigation identified RePEA as the best candidate in terms of both synthetic accessibility and metabolic stability to FAAH-mediated hydrolysis. The selected compound was synthesized and assayed ex vivo to monitor FAAH-mediated hydrolysis and to confirm its anti-inflammatory properties. 1H-NMR spectroscopy performed on membrane samples containing FAAH in integral membrane protein demonstrated that RePEA is not processed by FAAH, in contrast with PEA. Moreover, RePEA retains PEA's ability to inhibit LPS-induced cytokine release in both murine N9 microglial cells and human PMA-THP-1 cells.